Embryonic Par1 or Par2 deficiency does not rescue Thbd−/− embryos from growth arrest and rapid resorption
| Breeding pairs . | Embryonic genotype . | Thbd+/+ . | Thbd+/− . | Thbd−/− . |
|---|---|---|---|---|
| Par1+/−Thbd+/− × Par1−/ −Thbd+/−; n = 84, analysis at 10.5 dpc | Par1+/− | 25 | 38 | 0 |
| Par1−/− | 6 | 15 | 0 | |
| Par2+/−Thbd+/− × Par2+/−Thbd+/−; n = 56, analysis at 10.5 dpc | Par2+/+ | 3 | 3 | 0 |
| Par2+/− | 10 | 23 | 0 | |
| Par2−/− | 10 | 7 | 0 |
| Breeding pairs . | Embryonic genotype . | Thbd+/+ . | Thbd+/− . | Thbd−/− . |
|---|---|---|---|---|
| Par1+/−Thbd+/− × Par1−/ −Thbd+/−; n = 84, analysis at 10.5 dpc | Par1+/− | 25 | 38 | 0 |
| Par1−/− | 6 | 15 | 0 | |
| Par2+/−Thbd+/− × Par2+/−Thbd+/−; n = 56, analysis at 10.5 dpc | Par2+/+ | 3 | 3 | 0 |
| Par2+/− | 10 | 23 | 0 | |
| Par2−/− | 10 | 7 | 0 |
Pregnancies were analyzed at 10.5 dpc. Numbers represent embryos determined to be beyond Theiler stage 13 (which corresponds to E8.5) for the indicated genotypes. Complete absence of Par1 resulted in partial embryonic lethality, replicating published data.24,27 Absence of fetal Par1 or Par2 did not rescue Thbd−/− embryos, with rescue defined as the presence of Thbd−/− embryos beyond Theiler stage 13.