Characteristics of patients and sequencing analysis of monoclonal IGL gene in POEMS syndrome
| Patient No. . | Age at diagnosis, y . | Sex . | M protein . | Bone marrow plasma cells, % . | Serum VEGF, pg/mL . | Homoduplex band . | Vλ subfamily . | IGLV gene . | IGLJ gene . | ||
|---|---|---|---|---|---|---|---|---|---|---|---|
| Germline . | Homology, % . | Germline . | Homology, % . | ||||||||
| 1 | 31 | F | IgA-λ | 6.2 | >2000 | + | Vλ1 | IGLV1-44*01 | 90.4 | IGLJ3*02 | 92.1 |
| 2 | 37 | M | IgG-λ | 1.0 | >2000 | − | ND | ND | ND | ||
| 3 | 42 | M | IgG-λ | 1.4 | 7160 | ± | ND | ND | ND | ||
| 4 | 57 | F | IgG-λ | 0.4 | 1920 | + | Vλ1 | IGLV1-40*01 | 91.2 | IGLJ3*02 | 84.1 |
| 5 | 53 | M | IgA-λ | 2.2 | 2580 | + | Vλ1 | IGLV1-44*01 | 92.9 | IGLJ3*02 | 94.7 |
| 6 | 49 | M | IgG-λ | 1.4 | 1640 | + | Vλ1 | IGLV1-44*01 | 84.0 | IGLJ3*02 | 89.2 |
| 7 | 58 | M | IgG-λ | 2.4 | 2020 | − | ND | ND | ND | ||
| 8 | 69 | F | IgA-λ | 1.2 | 2730 | + | Vλ1 | IGLV1-44*01 | 96.1 | IGLJ3*02 | 97.3 |
| 9 | 69 | F | IgG-λ | 1.4 | 1750 | + | Vλ1 | IGLV1-44*01 | 81.5 | IGLJ3*02 | 81.1 |
| 10 | 73 | M | IgG-λ | 2.2 | 4720 | + | Vλ1 | IGLV1-40*01 | 91.6 | IGLJ3*02 | 94.4 |
| 11 | 66 | F | IgA-λ | 1.6 | >2000 | ± | ND | ND | ND | ||
| 12 | 40 | M | IgA-λ | 2.2 | 5110 | + | Vλ1 | IGLV1-44*01 | 93.6 | IGLJ3*02 | 97.3 |
| 13 | 65 | M | IgA-λ | 0.8 | 7970 | + | Vλ1 | IGLV1-44*01 | 95.4 | IGLJ3*02 | 100 |
| 14 | 53 | F | IgA-λ | 0.1 | 2440 | + | Vλ1 | IGLV1-44*01 | 88.3 | IGLJ3*02 | 89.2 |
| 15 | 58 | M | IgA-λ | 1.2 | 2950 | + | Vλ1 | IGLV1-44*01 | 96.9 | IGLJ3*02 | 94.6 |
| Median | 54.7 | 1.4 | |||||||||
| Patient No. . | Age at diagnosis, y . | Sex . | M protein . | Bone marrow plasma cells, % . | Serum VEGF, pg/mL . | Homoduplex band . | Vλ subfamily . | IGLV gene . | IGLJ gene . | ||
|---|---|---|---|---|---|---|---|---|---|---|---|
| Germline . | Homology, % . | Germline . | Homology, % . | ||||||||
| 1 | 31 | F | IgA-λ | 6.2 | >2000 | + | Vλ1 | IGLV1-44*01 | 90.4 | IGLJ3*02 | 92.1 |
| 2 | 37 | M | IgG-λ | 1.0 | >2000 | − | ND | ND | ND | ||
| 3 | 42 | M | IgG-λ | 1.4 | 7160 | ± | ND | ND | ND | ||
| 4 | 57 | F | IgG-λ | 0.4 | 1920 | + | Vλ1 | IGLV1-40*01 | 91.2 | IGLJ3*02 | 84.1 |
| 5 | 53 | M | IgA-λ | 2.2 | 2580 | + | Vλ1 | IGLV1-44*01 | 92.9 | IGLJ3*02 | 94.7 |
| 6 | 49 | M | IgG-λ | 1.4 | 1640 | + | Vλ1 | IGLV1-44*01 | 84.0 | IGLJ3*02 | 89.2 |
| 7 | 58 | M | IgG-λ | 2.4 | 2020 | − | ND | ND | ND | ||
| 8 | 69 | F | IgA-λ | 1.2 | 2730 | + | Vλ1 | IGLV1-44*01 | 96.1 | IGLJ3*02 | 97.3 |
| 9 | 69 | F | IgG-λ | 1.4 | 1750 | + | Vλ1 | IGLV1-44*01 | 81.5 | IGLJ3*02 | 81.1 |
| 10 | 73 | M | IgG-λ | 2.2 | 4720 | + | Vλ1 | IGLV1-40*01 | 91.6 | IGLJ3*02 | 94.4 |
| 11 | 66 | F | IgA-λ | 1.6 | >2000 | ± | ND | ND | ND | ||
| 12 | 40 | M | IgA-λ | 2.2 | 5110 | + | Vλ1 | IGLV1-44*01 | 93.6 | IGLJ3*02 | 97.3 |
| 13 | 65 | M | IgA-λ | 0.8 | 7970 | + | Vλ1 | IGLV1-44*01 | 95.4 | IGLJ3*02 | 100 |
| 14 | 53 | F | IgA-λ | 0.1 | 2440 | + | Vλ1 | IGLV1-44*01 | 88.3 | IGLJ3*02 | 89.2 |
| 15 | 58 | M | IgA-λ | 1.2 | 2950 | + | Vλ1 | IGLV1-44*01 | 96.9 | IGLJ3*02 | 94.6 |
| Median | 54.7 | 1.4 | |||||||||
ND indicates not determined; +, present; −, not present; and ±, slightly present.