Earliest detected TaqMAMA versus chimerism in relapsing patients after HSCT
| Patient no., mutation . | Time after HSCT, d . | Mutant DNA by TaqMAMA, %* . | Autologous cells, % . |
|---|---|---|---|
| D098 | |||
| KRAS 38G>A | 36 | 0.063 | 0 |
| KRAS 38G>A | 57 | 0.019 | 0 |
| KRAS 38G>A | 77 | 0.034 | 0 |
| KRAS 38G>A | 100 | 0.203 | 0 |
| Clinical relapse | 140 | 36.11 | 90 |
| D292 | |||
| PTPN11 227A>G | 18 | 0.159 | 0 |
| PTPN11 227A>G | 32 | 0.200 | 10 |
| Clinical relapse | 140 | ||
| D361 | |||
| NRAS 38G>A | 28 | 0.050 | 0 |
| NRAS 38G>A | 32 | 0.044 | 0 |
| NRAS 38G>A | 64 | 0.374 | 5 |
| Clinical relapse | 366 | ||
| D405 | |||
| NRAS 37G>C | 29 | 0.110 | 0 |
| NRAS 37G>C | 29 | 0.408 | 0 |
| NRAS 37G>C | 35 | 0.187 | 0 |
| NRAS 37G>C | 41 | 1.033 | 5 |
| Clinical relapse | 57 | ||
| I160 | |||
| PTPN11 226G>A | 33 | 0.069 | 0 |
| PTPN11 226G>A | 64 | 0.313 | 0 |
| PTPN11 226G>A | 77 | 0.044 | 0 |
| PTPN11 226G>A | 107 | 0.074 | 0 |
| PTPN11 226G>A | 180 | 0.000 | 0 |
| PTPN11 226G>A | 215 | 0.177 | 0 |
| PTPN11 226G>A | 229 | 0.472 | 0 |
| PTPN11 226G>A | 245 | 5.469 | 15 |
| Clinical relapse | 298 |
| Patient no., mutation . | Time after HSCT, d . | Mutant DNA by TaqMAMA, %* . | Autologous cells, % . |
|---|---|---|---|
| D098 | |||
| KRAS 38G>A | 36 | 0.063 | 0 |
| KRAS 38G>A | 57 | 0.019 | 0 |
| KRAS 38G>A | 77 | 0.034 | 0 |
| KRAS 38G>A | 100 | 0.203 | 0 |
| Clinical relapse | 140 | 36.11 | 90 |
| D292 | |||
| PTPN11 227A>G | 18 | 0.159 | 0 |
| PTPN11 227A>G | 32 | 0.200 | 10 |
| Clinical relapse | 140 | ||
| D361 | |||
| NRAS 38G>A | 28 | 0.050 | 0 |
| NRAS 38G>A | 32 | 0.044 | 0 |
| NRAS 38G>A | 64 | 0.374 | 5 |
| Clinical relapse | 366 | ||
| D405 | |||
| NRAS 37G>C | 29 | 0.110 | 0 |
| NRAS 37G>C | 29 | 0.408 | 0 |
| NRAS 37G>C | 35 | 0.187 | 0 |
| NRAS 37G>C | 41 | 1.033 | 5 |
| Clinical relapse | 57 | ||
| I160 | |||
| PTPN11 226G>A | 33 | 0.069 | 0 |
| PTPN11 226G>A | 64 | 0.313 | 0 |
| PTPN11 226G>A | 77 | 0.044 | 0 |
| PTPN11 226G>A | 107 | 0.074 | 0 |
| PTPN11 226G>A | 180 | 0.000 | 0 |
| PTPN11 226G>A | 215 | 0.177 | 0 |
| PTPN11 226G>A | 229 | 0.472 | 0 |
| PTPN11 226G>A | 245 | 5.469 | 15 |
| Clinical relapse | 298 |
Samples are adjusted for any false positive amplification.