APO866 inhibits the capacity of hematologic cancer cells to form colonies
| Colonies formed at 14 to 18 days . | ||
|---|---|---|
| Cells plated after 96-hour incubation . | Untreated cells . | Cell exposure to 10 nM APO866 . |
| Namalwa | ||
| 5 × 102 | 73 ± 11 | 0 |
| 5 × 103 | ND | 0 |
| 5 × 104 | ND | 0 |
| RajiGFP | ||
| 5 × 102 | 95 ± 4 | 0 |
| 5 × 103 | ND | 0 |
| 5 × 104 | ND | 0 |
| ML-2 | ||
| 5 × 102 | 134 ± 21 | 0 |
| 5 × 103 | ND | 0 |
| 5 × 104 | ND | 0 |
| Molt-4 | ||
| 5 × 102 | 120 ± 19 | 0 |
| 5 × 103 | ND | 0 |
| 5 × 104 | ND | 0 |
| EHEB | ||
| 5 × 102 | 374 ± 11.3 | 0 |
| 5 × 103 | ND | 0 |
| 5 × 104 | ND | 0 |
| HPCs | ||
| 2 × 103 | ||
| BFU-Es | 158 ± 62 | 103 ± 64 |
| CFU-GMs | 125 ± 67 | 169 ± 69 |
| Colonies formed at 14 to 18 days . | ||
|---|---|---|
| Cells plated after 96-hour incubation . | Untreated cells . | Cell exposure to 10 nM APO866 . |
| Namalwa | ||
| 5 × 102 | 73 ± 11 | 0 |
| 5 × 103 | ND | 0 |
| 5 × 104 | ND | 0 |
| RajiGFP | ||
| 5 × 102 | 95 ± 4 | 0 |
| 5 × 103 | ND | 0 |
| 5 × 104 | ND | 0 |
| ML-2 | ||
| 5 × 102 | 134 ± 21 | 0 |
| 5 × 103 | ND | 0 |
| 5 × 104 | ND | 0 |
| Molt-4 | ||
| 5 × 102 | 120 ± 19 | 0 |
| 5 × 103 | ND | 0 |
| 5 × 104 | ND | 0 |
| EHEB | ||
| 5 × 102 | 374 ± 11.3 | 0 |
| 5 × 103 | ND | 0 |
| 5 × 104 | ND | 0 |
| HPCs | ||
| 2 × 103 | ||
| BFU-Es | 158 ± 62 | 103 ± 64 |
| CFU-GMs | 125 ± 67 | 169 ± 69 |
Values represent the mean plus or minus the standard deviation (SD) of 3 independent experiments. BFU-Es are burst-forming units (erythroid colonies); CFU-G/Ms are granulocyte/macrophage colonies; HPCs are normal hematopoietic progenitor cells. ND indicates not done.