Effect of oral contraceptive use on the association of the Tyr204Phe variant of the coagulation FXIII subunit A gene and ischemic stroke
| . | . | Distribution in patients, % . | Distribution in controls, % . | Odds ratio (95% CI)* . | ||||
|---|---|---|---|---|---|---|---|---|
| Oral contraceptive use | 204Phe allele | Tyr/Tyr | Tyr/Phe | Phe/Phe | Tyr/Tyr† | Tyr/Phe | Phe/Phe | |
| Absent | Absent | 54 | — | — | 455 | — | — | 1 (reference) |
| Present | Absent | 62 | — | — | 250 | — | — | 2.6 (1.6-4.3) |
| Absent | Present | — | 29 | 2 | — | 26 | 1 | 8.8 (4.3-18) |
| Present | Present | — | 25 | 3 | — | 16 | 0 | 20 (9-46) |
| . | . | Distribution in patients, % . | Distribution in controls, % . | Odds ratio (95% CI)* . | ||||
|---|---|---|---|---|---|---|---|---|
| Oral contraceptive use | 204Phe allele | Tyr/Tyr | Tyr/Phe | Phe/Phe | Tyr/Tyr† | Tyr/Phe | Phe/Phe | |
| Absent | Absent | 54 | — | — | 455 | — | — | 1 (reference) |
| Present | Absent | 62 | — | — | 250 | — | — | 2.6 (1.6-4.3) |
| Absent | Present | — | 29 | 2 | — | 26 | 1 | 8.8 (4.3-18) |
| Present | Present | — | 25 | 3 | — | 16 | 0 | 20 (9-46) |
— indicates not applicable.
Odds ratios with 95% confidence interval assuming dominant inheritance (Tyr/Phe and Phe/Phe variant genotypes versus Tyr/Tyr) adjusted for age at index date, index year, residence, hypertension, diabetes, hyperlipidemia, and smoking.
Data on oral contraceptive use was missing in 6 controls.