Genotype distribution in patients and controls and odds ratios for ischemic stroke under a dominant genetic model
| Gene name (HUGO abbreviation) . | Variant . | RefSNP ID no. . | Distribution in patients (%) (n = 190) . | Distribution in controls (%) (n = 767) . | Odds ratio (95% CI)* . | ||||
|---|---|---|---|---|---|---|---|---|---|
| AA . | AB . | BB . | AA . | AB . | BB . | ||||
| Factor XIII subunit A (F13A1) | Val34Leu | rs5985 | 121 (64) | 60 (32) | 8 (4) | 419 (56) | 283 (38) | 45 (6) | 0.77 (0.53-1.11) |
| Factor XIII subunit A (F13A1) | Tyr204Phe | rs3024477 | 116 (66) | 54 (31) | 5 (3) | 711 (94) | 42 (6) | 1 (0) | 9.1 (5.5-15) |
| Factor XIII subunit A (F13A1) | Pro564Leu | rs5982 | 107 (62) | 57 (33) | 8 (5) | 466 (62) | 251 (33) | 34 (5) | 0.89 (0.61-1.29) |
| Factor XIII subunit B (F13B) | His95Arg | rs6003 | 134 (76) | 33 (19) | 10 (6) | 609 (83) | 112 (15) | 9 (1) | 1.7 (1.1-2.7) |
| Gene name (HUGO abbreviation) . | Variant . | RefSNP ID no. . | Distribution in patients (%) (n = 190) . | Distribution in controls (%) (n = 767) . | Odds ratio (95% CI)* . | ||||
|---|---|---|---|---|---|---|---|---|---|
| AA . | AB . | BB . | AA . | AB . | BB . | ||||
| Factor XIII subunit A (F13A1) | Val34Leu | rs5985 | 121 (64) | 60 (32) | 8 (4) | 419 (56) | 283 (38) | 45 (6) | 0.77 (0.53-1.11) |
| Factor XIII subunit A (F13A1) | Tyr204Phe | rs3024477 | 116 (66) | 54 (31) | 5 (3) | 711 (94) | 42 (6) | 1 (0) | 9.1 (5.5-15) |
| Factor XIII subunit A (F13A1) | Pro564Leu | rs5982 | 107 (62) | 57 (33) | 8 (5) | 466 (62) | 251 (33) | 34 (5) | 0.89 (0.61-1.29) |
| Factor XIII subunit B (F13B) | His95Arg | rs6003 | 134 (76) | 33 (19) | 10 (6) | 609 (83) | 112 (15) | 9 (1) | 1.7 (1.1-2.7) |
HUGO indicates Human Genome Organization; RefSNP ID no., reference single nucleotide polymorphism identification number; 95% CI, 95% confidence interval; AA, wild-type homozygote; AB, variant heterozygote; and BB, variant homozygote. Odds ratios are adjusted for age at index date, index year and residence. The total number of genotypes for each genetic variant does not add up to the total number of subjects because genotype was undetermined in some subjects. Percentages do not always add up to 100% due to rounding.
Odds ratio with 95% confidence interval assuming dominant inheritance: heterozygous (AB) and homozygous (BB) variant genotypes versus wild-type (AA).