Myeloid bone marrow differentials from LysM-Cre–deleted mice
| Genotype . | BM myeloid cells, % . | |||
|---|---|---|---|---|
| Myelocyte precursor . | Metamyelocyte . | Band cell . | Segmented neutrophil . | |
| Littemate control | 17 ± 0 | 13 ± 1 | 22 ± 5 | 48 ± 4 |
| Mcl-1f/null plus LysM-Cre | 59 ± 4 | 28 ± 4 | 11 ± 4 | 1 ± 1* |
| Bimf/f plus LysM-Cre | 13 ± 2 | 7 ± 2 | 15 ± 4 | 65 ± 1 |
| Mcl-1f/nullBimf/f plus LysM-Cre | 63 ± 7 | 26 ± 8 | 10 ± 2 | 0 ± 0* |
| Pumanull | 25 ± 6 | 16 ± 2 | 11 ± 3 | 48 ± 7 |
| Mcl-1f/nullPumanull plus LysM-Cre | 66 ± 5 | 26 ± 8 | 9 ± 2 | 1 ± 1* |
| Mcl-1f/null Bimf/f Pumanull plus LysM-Cre | 74 ± 1 | 22 ± 2 | 5 ± 2 | 1 ± 1* |
| Baxf/fBaknull plus LysM-Cre | 20 ± 6 | 11 ± 2 | 15 ± 2 | 54 ± 7 |
| Mcl-1f/f Baxf/f Baknull plus LysM-Cre | 15 ± 2 | 9 ± 1 | 14 ± 2 | 63 ± 4 |
| Genotype . | BM myeloid cells, % . | |||
|---|---|---|---|---|
| Myelocyte precursor . | Metamyelocyte . | Band cell . | Segmented neutrophil . | |
| Littemate control | 17 ± 0 | 13 ± 1 | 22 ± 5 | 48 ± 4 |
| Mcl-1f/null plus LysM-Cre | 59 ± 4 | 28 ± 4 | 11 ± 4 | 1 ± 1* |
| Bimf/f plus LysM-Cre | 13 ± 2 | 7 ± 2 | 15 ± 4 | 65 ± 1 |
| Mcl-1f/nullBimf/f plus LysM-Cre | 63 ± 7 | 26 ± 8 | 10 ± 2 | 0 ± 0* |
| Pumanull | 25 ± 6 | 16 ± 2 | 11 ± 3 | 48 ± 7 |
| Mcl-1f/nullPumanull plus LysM-Cre | 66 ± 5 | 26 ± 8 | 9 ± 2 | 1 ± 1* |
| Mcl-1f/null Bimf/f Pumanull plus LysM-Cre | 74 ± 1 | 22 ± 2 | 5 ± 2 | 1 ± 1* |
| Baxf/fBaknull plus LysM-Cre | 20 ± 6 | 11 ± 2 | 15 ± 2 | 54 ± 7 |
| Mcl-1f/f Baxf/f Baknull plus LysM-Cre | 15 ± 2 | 9 ± 1 | 14 ± 2 | 63 ± 4 |
Compilation of average manual differential myeloid BM counts for cohorts of age-matched mice of indicated genotypes. Each data set is composed of at least 3 mice per group. Error represents SEM.
P < .01 by 2-tailed t test when compared with littermate control population.