List of (putative) transcription factors identified as early induced by retinoic acid in NB4 cells
| Gene symbol . | Full name . | Accession no. . | Direct target of retinoic acid* . | Expressed in myeloid tissue‡ . | Reference(s) . |
|---|---|---|---|---|---|
| CEBPB | CAAT/enhancer binding protein, beta | NM_005194 | Yes† | Yes | Duprez et al6 |
| CHOP | C/EBP-homologous protein | NM_004083 | Yes | Yes | Gery et al16 |
| ID1 | Inhibitor of DNA-binding 1 | NM_002165 | Yes | Yes | Nigten et al17 ; Jankovic et al18 |
| ID2 | Inhibitor of DNA-binding 2 | NM_002166 | Yes | Yes | Nigten et al17 |
| IRF1 | Interferon regulatory factor 1 | NM_002198 | Yes | Yes | Matikainen et al19 |
| BHLHB2 | Basic helix-loop-helix domain containing, class B, 2 | NM_003670 | Yes | ?§ | Boudjelal et al20 |
| ZC3H12A | Zinc-finger CCCH-type containing 12A | NM_025079 | ? | Yes | Zhou et al21 ; Liang et al22 |
| ZNF767 | Zinc-finger containing protein 767 | NM_024910 | ? | ? | |
| CXXC5 (RINF) | CXXC zinc-finger 5 (retinoid-inducible nuclear factor) | NM_016463 | ? | ? |
| Gene symbol . | Full name . | Accession no. . | Direct target of retinoic acid* . | Expressed in myeloid tissue‡ . | Reference(s) . |
|---|---|---|---|---|---|
| CEBPB | CAAT/enhancer binding protein, beta | NM_005194 | Yes† | Yes | Duprez et al6 |
| CHOP | C/EBP-homologous protein | NM_004083 | Yes | Yes | Gery et al16 |
| ID1 | Inhibitor of DNA-binding 1 | NM_002165 | Yes | Yes | Nigten et al17 ; Jankovic et al18 |
| ID2 | Inhibitor of DNA-binding 2 | NM_002166 | Yes | Yes | Nigten et al17 |
| IRF1 | Interferon regulatory factor 1 | NM_002198 | Yes | Yes | Matikainen et al19 |
| BHLHB2 | Basic helix-loop-helix domain containing, class B, 2 | NM_003670 | Yes | ?§ | Boudjelal et al20 |
| ZC3H12A | Zinc-finger CCCH-type containing 12A | NM_025079 | ? | Yes | Zhou et al21 ; Liang et al22 |
| ZNF767 | Zinc-finger containing protein 767 | NM_024910 | ? | ? | |
| CXXC5 (RINF) | CXXC zinc-finger 5 (retinoid-inducible nuclear factor) | NM_016463 | ? | ? |
As suggested in the literature by at least cycloheximide experiment (not necessarily for the presence of a putative retinoid-responsive element in the gene promoter).
CEBPB would be a direct target of retinoic acid in PML-RARα expressing cells (ie, in APL cells but apparently not in other cells).
As suggested at least by Northern blot, RT-PCR, and/or Western blot experiments (data that are only based on microarray experiments were not considered here).
A question mark (?) indicates that there is no evidence in the literature to our knowledge.