Demographics and baseline characteristics
| Parameters . | Median . |
|---|---|
| Demography | |
| Age, y (min-max) | 61 (27-82) |
| Male, no. (%) | 19 (58%) |
| White, no. (%) | 33 (100%) |
| Disease characteristics (min-max) | |
| Duration of CLL, y | 6.3 (1.2-14) |
| Time from latest treatment, y | 0.8 (0.1-5.3) |
| No. of previous treatments | 3 (1-9) |
| Modified Rai stage at screening, no. (%) | |
| 0 | 1 (3) |
| I | 13 (39) |
| II | 15 (45) |
| III | 1 (3) |
| IV | 3 (9) |
| Modified Binet stage at screening, no. (%) | |
| A | 7 (21) |
| B | 22 (67) |
| C | 4 (12) |
| Constitutional symptoms, no. (%) | |
| Extreme fatigue | 2 (6) |
| Night sweats | 5 (15) |
| Fever | 0 |
| Weight loss | 0 |
| Hematologic symptoms, no. (%) | |
| Anemia, hemoglobin level less than 10 g/L | 7 (21) |
| Neutropenia, neutrophil count less than 1.5×109/L | 0 (0) |
| Thrombocytopenia, platelet count less than 120×109/L | 9 (27) |
| Lymphocytes/109/L (min-max) | 51.3 (8.2-227.2) |
| LDH level above normal value, no. (%) | 7 (21) |
| Lymph nodes, no. (%) | |
| None | 5 (15) |
| More than 5 cm in diameter | 4 (12) |
| SPD more than 50 cm2; | 4 (12) |
| Splenomegaly, no. (%) | |
| No | 22 (67) |
| More than 5 cm below diaphragm | 2 (6) |
| Parameters . | Median . |
|---|---|
| Demography | |
| Age, y (min-max) | 61 (27-82) |
| Male, no. (%) | 19 (58%) |
| White, no. (%) | 33 (100%) |
| Disease characteristics (min-max) | |
| Duration of CLL, y | 6.3 (1.2-14) |
| Time from latest treatment, y | 0.8 (0.1-5.3) |
| No. of previous treatments | 3 (1-9) |
| Modified Rai stage at screening, no. (%) | |
| 0 | 1 (3) |
| I | 13 (39) |
| II | 15 (45) |
| III | 1 (3) |
| IV | 3 (9) |
| Modified Binet stage at screening, no. (%) | |
| A | 7 (21) |
| B | 22 (67) |
| C | 4 (12) |
| Constitutional symptoms, no. (%) | |
| Extreme fatigue | 2 (6) |
| Night sweats | 5 (15) |
| Fever | 0 |
| Weight loss | 0 |
| Hematologic symptoms, no. (%) | |
| Anemia, hemoglobin level less than 10 g/L | 7 (21) |
| Neutropenia, neutrophil count less than 1.5×109/L | 0 (0) |
| Thrombocytopenia, platelet count less than 120×109/L | 9 (27) |
| Lymphocytes/109/L (min-max) | 51.3 (8.2-227.2) |
| LDH level above normal value, no. (%) | 7 (21) |
| Lymph nodes, no. (%) | |
| None | 5 (15) |
| More than 5 cm in diameter | 4 (12) |
| SPD more than 50 cm2; | 4 (12) |
| Splenomegaly, no. (%) | |
| No | 22 (67) |
| More than 5 cm below diaphragm | 2 (6) |