Table 2 Platelet response of enrolled... | American Society of Hematology

Table 2

Platelet response of enrolled patients

Patient ID	Visits as responder, %*	Visits with plt count > 30 × 10⁹/L, %	Visits with plt count > 50 × 10⁹/L, %	Visits IVIg given, %	Baseline plt count, ×10⁹/L†	Max plt count, ×10⁹/L‡	Med plt count, ×10⁹/L§	No. of dose changes	Steroids tapered‖
Maintained response¶
1	100	100	100	0	6	458	216	0	No
2	100	100	100	0	12	154	100	0	Yes
3	100	100	100	0	22	159	106	1	Yes
4	95	100	95	0	22	190	104	1	Yes
5	94	100	94	0	16	197	127	0	Yes
6	91	95	95	5	2	394	317	0	No
7	77	96	58	0	20	111	55	0	No
8	68	68	45	0	11	186	43	1	No
Median	91	96	94	0	16	190	104	0
Nonmaintained response#
9	23	32	17	4	12	195	23	4	No
10	25	45	35	20	6	98	14	4	Yes
11	24	72	24	0	28	158	36	4	No
12	20	49	14	0	22	222	27	4	No
Median	24	47	21	2	17	177	25	4
No response**
13	0	6	0	78	11	16	10	4	No
14	0	0	0	73	18	13	12	2	No
15	0	0	0	0	16	15	14	0	No
16	0	0	0	25	3	13	9	0	No
Median	0	0	0	49	14	14	11	1

Patient ID	Visits as responder, %*	Visits with plt count > 30 × 10⁹/L, %	Visits with plt count > 50 × 10⁹/L, %	Visits IVIg given, %	Baseline plt count, ×10⁹/L†	Max plt count, ×10⁹/L‡	Med plt count, ×10⁹/L§	No. of dose changes	Steroids tapered‖
Maintained response¶
1	100	100	100	0	6	458	216	0	No
2	100	100	100	0	12	154	100	0	Yes
3	100	100	100	0	22	159	106	1	Yes
4	95	100	95	0	22	190	104	1	Yes
5	94	100	94	0	16	197	127	0	Yes
6	91	95	95	5	2	394	317	0	No
7	77	96	58	0	20	111	55	0	No
8	68	68	45	0	11	186	43	1	No
Median	91	96	94	0	16	190	104	0
Nonmaintained response#
9	23	32	17	4	12	195	23	4	No
10	25	45	35	20	6	98	14	4	Yes
11	24	72	24	0	28	158	36	4	No
12	20	49	14	0	22	222	27	4	No
Median	24	47	21	2	17	177	25	4
No response**
13	0	6	0	78	11	16	10	4	No
14	0	0	0	73	18	13	12	2	No
15	0	0	0	0	16	15	14	0	No
16	0	0	0	25	3	13	9	0	No
Median	0	0	0	49	14	14	11	1

Subjects 1-3, 5, 6, 8-10, and 12-14 had undergone splenectomy; subjects 6, 8, 9, 13, and 16 had failed a thrombopoietic agent.

Plt indicates platelet; max, maximum; and med, median.

Responder was defined as increase in platelet count by more than 20 × 10⁹/L to greater than 30 × 10⁹/L.

Baseline value is within 1 month before first dose of study drug.

Max value is while on study drug with no IVIg treatment in preceding 2 weeks.

Median value is while on study drug with no IVIg treatment in preceding 2 weeks.

Steroids include prednisone, methylprednisolone, and danazol.

Platelets increased by greater than 20 × 10⁹/L to greater than 30 × 10⁹/L for at least 66% of visits.

Platelets increased by greater than 20 × 10⁹/L to greater than 30 × 10⁹/L for less than 66% of study visits.

Platelets did not increase by greater than 20 × 10⁹/L to greater than 30 × 10⁹/L.