Impact of HLA mismatches in allele level on relapse
| . | All diseases . | ||
|---|---|---|---|
| n . | HR (95% CI) . | P . | |
| HLA-A matched | 4018 | 1.00 (ref) | |
| HLA-A 1 allele mismatched | 597 | 1.00 (0.82-1.22) | .99 |
| HLA-A 2 alleles mismatched | 28 | 0.79 (0.28-2.28) | .67 |
| HLA-B matched | 4351 | 1.00 (ref) | |
| HLA-B 1 allele mismatched | 288 | 1.06 (0.79-1.41) | .7 |
| HLA-B 2 alleles mismatched* | 4 | ND | ND |
| HLA-C matched | 3308 | 1.00 (ref) | |
| HLA-C 1 allele mismatched | 1212 | 0.68 (0.58-0.80) | <.001 |
| HLA-C 2 alleles mismatched | 123 | 0.43 (0.24-0.75) | .003 |
| HLA-DRB1 matched | 3718 | 1.00 (ref) | |
| HLA-DRB1 1 allele mismatched | 866 | 0.93 (0.74-1.18) | .56 |
| HLA-DRB1 2 alleles mismatched | 59 | 1.18 (0.53-2.63) | .68 |
| HLA-DQB1 matched | 3597 | 1.00 (ref) | |
| HLA-DQB1 1 allele mismatched | 958 | 1.12 (0.90-1.40) | .30 |
| HLA-DQB1 2 alleles mismatched | 88 | 0.73 (0.35-1.52) | .40 |
| HLA-DPB1 matched | 1584 | 1.00 (ref) | |
| HLA-DPB1 1 allele mismatched | 2190 | 0.80 (0.70-0.92) | .002 |
| HLA-DPB1 2 alleles mismatched | 869 | 0.62 (0.51-0.75) | <.001 |
| . | All diseases . | ||
|---|---|---|---|
| n . | HR (95% CI) . | P . | |
| HLA-A matched | 4018 | 1.00 (ref) | |
| HLA-A 1 allele mismatched | 597 | 1.00 (0.82-1.22) | .99 |
| HLA-A 2 alleles mismatched | 28 | 0.79 (0.28-2.28) | .67 |
| HLA-B matched | 4351 | 1.00 (ref) | |
| HLA-B 1 allele mismatched | 288 | 1.06 (0.79-1.41) | .7 |
| HLA-B 2 alleles mismatched* | 4 | ND | ND |
| HLA-C matched | 3308 | 1.00 (ref) | |
| HLA-C 1 allele mismatched | 1212 | 0.68 (0.58-0.80) | <.001 |
| HLA-C 2 alleles mismatched | 123 | 0.43 (0.24-0.75) | .003 |
| HLA-DRB1 matched | 3718 | 1.00 (ref) | |
| HLA-DRB1 1 allele mismatched | 866 | 0.93 (0.74-1.18) | .56 |
| HLA-DRB1 2 alleles mismatched | 59 | 1.18 (0.53-2.63) | .68 |
| HLA-DQB1 matched | 3597 | 1.00 (ref) | |
| HLA-DQB1 1 allele mismatched | 958 | 1.12 (0.90-1.40) | .30 |
| HLA-DQB1 2 alleles mismatched | 88 | 0.73 (0.35-1.52) | .40 |
| HLA-DPB1 matched | 1584 | 1.00 (ref) | |
| HLA-DPB1 1 allele mismatched | 2190 | 0.80 (0.70-0.92) | .002 |
| HLA-DPB1 2 alleles mismatched | 869 | 0.62 (0.51-0.75) | <.001 |
Each group was compared with the matched group in each locus after adjusting for other matching status of HLA, sex (donor-recipient pairs), patient age (linear), donor age (linear), type of disease, risk of leukemia relapse (standard, high, and diseases other than leukemia), GVHD prophylaxis (CSP vs FK), ATG vs no ATG), and preconditioning (TBI vs non-TBI).
ref indicates reference; and ND, not determined.
Comprehensive analysis could not be performed due to the small number of cases.