Patient characteristics
. | Total . | A locus . | B locus . | C locus . | DRB1 locus . | DQB1 locus . | DPB1 locus . | ||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Match . | Mismatch . | Match . | Mismatch . | Match . | Mismatch . | Match . | Mismatch . | Match . | Mismatch . | Match . | Mismatch . | ||
4643 | 4018 | 625 | 4351 | 292 | 3308 | 1335 | 3718 | 925 | 3597 | 1046 | 1584 | 3059 | |
Median age, y | 31.5 | 31.8 | 29.6 | 31.7 | 28.3 | 31.8 | 30.9 | 31.7 | 30.9 | 31.7 | 30.8 | 31.8 | 31.4 |
Sex, donor/patient | |||||||||||||
Male/male | 1904 | 1673 | 231 | 1769 | 135 | 1387 | 517 | 1551 | 353 | 1492 | 412 | 678 | 1226 |
Male/female | 923 | 789 | 134 | 874 | 49 | 650 | 273 | 734 | 189 | 704 | 219 | 299 | 624 |
Female/male | 894 | 747 | 147 | 843 | 51 | 634 | 260 | 693 | 201 | 672 | 222 | 268 | 626 |
Female/female | 922 | 809 | 113 | 865 | 57 | 637 | 285 | 740 | 182 | 729 | 193 | 339 | 583 |
Disease | |||||||||||||
ALL | 1464 | 1267 | 197 | 1372 | 92 | 1051 | 413 | 161 | 303 | 1132 | 332 | 452 | 1012 |
AML | 1571 | 1360 | 211 | 1478 | 93 | 1114 | 457 | 1255 | 316 | 1224 | 347 | 574 | 997 |
CML | 979 | 827 | 152 | 905 | 74 | 682 | 297 | 779 | 200 | 746 | 233 | 343 | 636 |
ML | 564 | 507 | 57 | 536 | 28 | 43 | 146 | 468 | 96 | 49 | 118 | 192 | 372 |
MM | 65 | 57 | 8 | 60 | 5 | 418 | 22 | 55 | 10 | 446 | 16 | 23 | 42 |
Risk of leukemia relapse* | |||||||||||||
Standard risk | 1684 | 1485 | 199 | 1588 | 96 | 1184 | 500 | 1375 | 309 | 1322 | 362 | 572 | 1112 |
High risk | 1909 | 1607 | 302 | 1772 | 137 | 1365 | 544 | 1485 | 424 | 1451 | 458 | 642 | 1267 |
Disease other than leukemia | 1050 | 926 | 124 | 991 | 59 | 759 | 291 | 858 | 192 | 824 | 226 | 370 | 680 |
GVHD prophylaxis | |||||||||||||
Cyclosporine-based | 2503 | 2159 | 344 | 2346 | 157 | 1802 | 701 | 2107 | 396 | 2030 | 473 | 881 | 1622 |
Tacrolimus-based | 2140 | 1859 | 281 | 2005 | 135 | 1506 | 634 | 1611 | 529 | 1567 | 573 | 703 | 1437 |
ATG | |||||||||||||
ATG | 152 | 112 | 40 | 135 | 17 | 102 | 50 | 110 | 42 | 118 | 34 | 51 | 101 |
Non-ATG | 4491 | 3906 | 585 | 4216 | 275 | 3206 | 1285 | 3608 | 883 | 3479 | 1012 | 1533 | 2958 |
Preconditioning | |||||||||||||
TBI regimen | 3687 | 3175 | 512 | 3445 | 242 | 2623 | 1064 | 2933 | 754 | 2834 | 853 | 1242 | 2445 |
Non-TBI regimen | 956 | 843 | 113 | 906 | 50 | 685 | 271 | 785 | 171 | 763 | 193 | 342 | 614 |
. | Total . | A locus . | B locus . | C locus . | DRB1 locus . | DQB1 locus . | DPB1 locus . | ||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Match . | Mismatch . | Match . | Mismatch . | Match . | Mismatch . | Match . | Mismatch . | Match . | Mismatch . | Match . | Mismatch . | ||
4643 | 4018 | 625 | 4351 | 292 | 3308 | 1335 | 3718 | 925 | 3597 | 1046 | 1584 | 3059 | |
Median age, y | 31.5 | 31.8 | 29.6 | 31.7 | 28.3 | 31.8 | 30.9 | 31.7 | 30.9 | 31.7 | 30.8 | 31.8 | 31.4 |
Sex, donor/patient | |||||||||||||
Male/male | 1904 | 1673 | 231 | 1769 | 135 | 1387 | 517 | 1551 | 353 | 1492 | 412 | 678 | 1226 |
Male/female | 923 | 789 | 134 | 874 | 49 | 650 | 273 | 734 | 189 | 704 | 219 | 299 | 624 |
Female/male | 894 | 747 | 147 | 843 | 51 | 634 | 260 | 693 | 201 | 672 | 222 | 268 | 626 |
Female/female | 922 | 809 | 113 | 865 | 57 | 637 | 285 | 740 | 182 | 729 | 193 | 339 | 583 |
Disease | |||||||||||||
ALL | 1464 | 1267 | 197 | 1372 | 92 | 1051 | 413 | 161 | 303 | 1132 | 332 | 452 | 1012 |
AML | 1571 | 1360 | 211 | 1478 | 93 | 1114 | 457 | 1255 | 316 | 1224 | 347 | 574 | 997 |
CML | 979 | 827 | 152 | 905 | 74 | 682 | 297 | 779 | 200 | 746 | 233 | 343 | 636 |
ML | 564 | 507 | 57 | 536 | 28 | 43 | 146 | 468 | 96 | 49 | 118 | 192 | 372 |
MM | 65 | 57 | 8 | 60 | 5 | 418 | 22 | 55 | 10 | 446 | 16 | 23 | 42 |
Risk of leukemia relapse* | |||||||||||||
Standard risk | 1684 | 1485 | 199 | 1588 | 96 | 1184 | 500 | 1375 | 309 | 1322 | 362 | 572 | 1112 |
High risk | 1909 | 1607 | 302 | 1772 | 137 | 1365 | 544 | 1485 | 424 | 1451 | 458 | 642 | 1267 |
Disease other than leukemia | 1050 | 926 | 124 | 991 | 59 | 759 | 291 | 858 | 192 | 824 | 226 | 370 | 680 |
GVHD prophylaxis | |||||||||||||
Cyclosporine-based | 2503 | 2159 | 344 | 2346 | 157 | 1802 | 701 | 2107 | 396 | 2030 | 473 | 881 | 1622 |
Tacrolimus-based | 2140 | 1859 | 281 | 2005 | 135 | 1506 | 634 | 1611 | 529 | 1567 | 573 | 703 | 1437 |
ATG | |||||||||||||
ATG | 152 | 112 | 40 | 135 | 17 | 102 | 50 | 110 | 42 | 118 | 34 | 51 | 101 |
Non-ATG | 4491 | 3906 | 585 | 4216 | 275 | 3206 | 1285 | 3608 | 883 | 3479 | 1012 | 1533 | 2958 |
Preconditioning | |||||||||||||
TBI regimen | 3687 | 3175 | 512 | 3445 | 242 | 2623 | 1064 | 2933 | 754 | 2834 | 853 | 1242 | 2445 |
Non-TBI regimen | 956 | 843 | 113 | 906 | 50 | 685 | 271 | 785 | 171 | 763 | 193 | 342 | 614 |
ATG indicates antithymocyte globulin; and TBI, total body irradiation.
Standard risk for leukemia relapse was defined as the status of the first complete remission of AML and ALL and the first chronic phase of CML at transplant, while high risk was defined as a more advanced status than standard risk in AML, ALL, and CML. Disease other than leukemia was defined as other than ALL, AML, and CML.