Dose adjustment rules
| Platelet count, ×109/L . | Action . |
|---|---|
| ≤ 10 | Dose increased by 2 μg/kg every week when platelet counts were ≤ 10 × 109/L. (Dose could be increased every week.) |
| > 10 to < 50 | Dose increased by 2 μg/kg after 2 consecutive weeks of platelet counts < 50 × 109/L. (Dose could be increased every 2 weeks.) |
| 50 to 250 | Dose could be adjusted by 1 μg/kg (increased or decreased) at the investigator's discretion, no more frequently than every 2 weeks. The maximum dose was 10 μg/kg weekly. |
| > 250 to < 400 | Dose reduced by 1 μg/kg after 2 consecutive weeks of platelet counts in this range. (Dose could be reduced every 2 weeks.) |
| ≥ 400 | Next scheduled dose was held. On the next scheduled dosing day that the platelet count was < 250 × 109/L, the dose was reduced by 1 μg/kg. |
| Platelet count, ×109/L . | Action . |
|---|---|
| ≤ 10 | Dose increased by 2 μg/kg every week when platelet counts were ≤ 10 × 109/L. (Dose could be increased every week.) |
| > 10 to < 50 | Dose increased by 2 μg/kg after 2 consecutive weeks of platelet counts < 50 × 109/L. (Dose could be increased every 2 weeks.) |
| 50 to 250 | Dose could be adjusted by 1 μg/kg (increased or decreased) at the investigator's discretion, no more frequently than every 2 weeks. The maximum dose was 10 μg/kg weekly. |
| > 250 to < 400 | Dose reduced by 1 μg/kg after 2 consecutive weeks of platelet counts in this range. (Dose could be reduced every 2 weeks.) |
| ≥ 400 | Next scheduled dose was held. On the next scheduled dosing day that the platelet count was < 250 × 109/L, the dose was reduced by 1 μg/kg. |