Significantly expanded TCR Vβ-expressing CD4+ T cells at baseline and during follow-up after ASCT in patients 4 to 7
| Patient no.TCR . | Beforetransplantation . | 3 months after transplantation . | 6 months after transplantation . | 1 year after transplantation . | 2 years after transplantation . | 3 years after transplantation . | 4 years after transplantation . |
|---|---|---|---|---|---|---|---|
| 4 | |||||||
| BV5.1 | 5.5 | 8.1* | 11.8* | 8.9* | 7.9 | 7.6 | 8.3* |
| BV5.2 | 1.7 | 2.4* | 1.8 | 1.5 | 1.2 | 1.1 | 1.1 |
| BV7.1 | 1.9 | 3.2* | 1.9 | 2.7* | 2.2 | 2.1 | 2.2 |
| BV9 | 4.5 | 6.4* | 4.3 | 3.5 | 3.0 | 3.3 | 2.9 |
| BV13.6 | 1.5 | 6.7* | 1.9 | 2.2 | 0.6 | 2.3 | 2.0 |
| BV16 | 5.7* | 0.5 | 0.3 | 0.6 | 0.2 | 1.1 | 0.7 |
| 5 | |||||||
| BV14 | 8.4* | — | — | — | — | — | — |
| 6 | |||||||
| BV7.2 | 2.7* | 1.7 | 1.4 | 1.9 | 1.6 | 1.4 | 2.0 |
| BV12 | 2.1 | 2.3 | 2.5 | 2.2 | 2.7* | 2.5 | 2.6 |
| BV13.2 | 5.0* | 3.5 | 2.9 | 3.4 | 3.4 | 3.1 | 3.5 |
| BV20 | 3.7* | 4.7* | 1.1 | 1.5 | 2.1 | 1.4 | 2.1 |
| 7 | |||||||
| BV4 | 2.6* | 1.9 | 2.6* | 2.2 | 2.3 | — | — |
| BV12 | 2.1 | 3.4* | 3.2* | 2.5 | 1.7 | — | — |
| BV13.1 | 5.2 | 12.9* | 4.7 | 4.8 | 5.1 | — | — |
| Patient no.TCR . | Beforetransplantation . | 3 months after transplantation . | 6 months after transplantation . | 1 year after transplantation . | 2 years after transplantation . | 3 years after transplantation . | 4 years after transplantation . |
|---|---|---|---|---|---|---|---|
| 4 | |||||||
| BV5.1 | 5.5 | 8.1* | 11.8* | 8.9* | 7.9 | 7.6 | 8.3* |
| BV5.2 | 1.7 | 2.4* | 1.8 | 1.5 | 1.2 | 1.1 | 1.1 |
| BV7.1 | 1.9 | 3.2* | 1.9 | 2.7* | 2.2 | 2.1 | 2.2 |
| BV9 | 4.5 | 6.4* | 4.3 | 3.5 | 3.0 | 3.3 | 2.9 |
| BV13.6 | 1.5 | 6.7* | 1.9 | 2.2 | 0.6 | 2.3 | 2.0 |
| BV16 | 5.7* | 0.5 | 0.3 | 0.6 | 0.2 | 1.1 | 0.7 |
| 5 | |||||||
| BV14 | 8.4* | — | — | — | — | — | — |
| 6 | |||||||
| BV7.2 | 2.7* | 1.7 | 1.4 | 1.9 | 1.6 | 1.4 | 2.0 |
| BV12 | 2.1 | 2.3 | 2.5 | 2.2 | 2.7* | 2.5 | 2.6 |
| BV13.2 | 5.0* | 3.5 | 2.9 | 3.4 | 3.4 | 3.1 | 3.5 |
| BV20 | 3.7* | 4.7* | 1.1 | 1.5 | 2.1 | 1.4 | 2.1 |
| 7 | |||||||
| BV4 | 2.6* | 1.9 | 2.6* | 2.2 | 2.3 | — | — |
| BV12 | 2.1 | 3.4* | 3.2* | 2.5 | 1.7 | — | — |
| BV13.1 | 5.2 | 12.9* | 4.7 | 4.8 | 5.1 | — | — |
— indicates not applicable.
Significant expansions according to criteria described in “Methods.”