SNPs and target genes comprising the genetic signature for susceptibility to ara-C from the whole genome analysis for AUC in both CEU and YRI populations
| Population/SNP . | Chromosome . | pQTL, P . | eQTL, P . | eQTL target gene . | Target gene chromosome . | Target gene ID . | Expression AUC, P . |
|---|---|---|---|---|---|---|---|
| CEU | |||||||
| rs17763463 | 2 | .00005 | .0000001 | GIT1 | 17 | 28964 | .00007 |
| rs7600852 | 2 | .00005 | .0000001 | GIT1 | 17 | 28964 | .00007 |
| rs17808412* | 3 | .00001 | .000001 | GIT1 | 17 | 28964 | .00007 |
| rs13358399 | 5 | .0001 | .000004 | C3orf6 | 152137 | .00008 | |
| rs2775139* | 13 | .000008 | .000001 | SLC25A37 | 8 | 51312 | .00069 |
| rs2775134 | 13 | .00002 | .000002 | SLC25A37 | 8 | 51312 | .00069 |
| rs1332944 | 13 | .00002 | .000002 | SLC25A37 | 8 | 51312 | .00069 |
| rs2585498 | 13 | .00002 | .000002 | SLC25A37 | 8 | 51312 | .00069 |
| rs2585499 | 13 | .00001 | .000003 | SLC25A37 | 8 | 51312 | .00069 |
| rs17795186* | 11 | .0001 | .000002 | P2RX1 | 17 | 5023 | .004 |
| rs17763463 | 2 | .00005 | .000001 | PTPRS | 19 | 5802 | .0102 |
| rs7600852 | 2 | .00005 | .000001 | PTPRS | 19 | 5802 | .0102 |
| rs368182* | 16 | .0001 | .000003 | CCDC24 | 1 | 149473 | .0426 |
| YRI | |||||||
| rs938562* | 4 | .0001 | .000003 | RPS6KA2 | 6 | 6196 | .00002 |
| rs16836417 | 1 | .0001 | .000001 | BMP3 | 4 | 651 | .00052 |
| rs16836421 | 1 | .0001 | .000001 | BMP3 | 4 | 651 | .00052 |
| rs16836403 | 1 | .0001 | .000001 | BMP3 | 4 | 651 | .00052 |
| rs11799391 | 1 | .0001 | .000001 | BMP3 | 4 | 651 | .00052 |
| rs4742299 | 9 | .00009 | .0000002 | DNAJB1 | 19 | 3337 | .00074 |
| rs4742299 | 9 | .00009 | .0000002 | MIST | 19 | 116449 | .00074 |
| rs11677428 | 2 | .00001 | .0000008 | LOC731990 | 1 | 731990 | .00123 |
| rs11677428 | 2 | .00001 | .0000008 | SDC3 | 1 | 9672 | .00123 |
| rs10973320 | 9 | .00002 | .00000004 | RAD51AP1 | 12 | 10635 | .00295 |
| rs10906723* | 10 | .0001 | .000002 | SSH2 | 17 | 85464 | .00549 |
| rs10906723* | 10 | .0001 | .000002 | LOC399491 | 17 | 399491 | .00549 |
| rs12225692 | 11 | .00009 | .000002 | NAB2 | 12 | 4665 | .00743 |
| rs16919696 | 8 | .00005 | .0000006 | CLDN16 | 3 | 10686 | .00846 |
| rs2430853* | 18 | .00001 | .0000004 | ANPEP | 15 | 290 | .017 |
| rs4634268 | 4 | .0001 | .000001 | ANPEP | 15 | 290 | .017 |
| rs10906723 | 10 | .0001 | .000002 | FAM78A | 9 | 286336 | .0174 |
| rs10461692 | 5 | .00008 | .000001 | FAM129A | 1 | 116496 | .0189 |
| rs11957363 | 5 | .0001 | .0000007 | FAM129A | 1 | 116496 | .0189 |
| rs17667845 | 5 | .0001 | .0000007 | FAM129A | 1 | 116496 | .0189 |
| rs17604706 | 5 | .0001 | .0000007 | FAM129A | 1 | 116496 | .0189 |
| rs1392421 | 5 | .0001 | .0000007 | FAM129A | 1 | 116496 | .0189 |
| rs6591904 | 11 | .0001 | .0000004 | BLVRB | 19 | 645 | .0223 |
| rs12712001 | 2 | .0001 | .000003 | ALK | 10 | 238 | .0234 |
| rs12712001 | 2 | .0001 | .000003 | LOC730467 | 10 | 730467 | .0234 |
| rs12712001 | 2 | .0001 | .000003 | LOC729342 | 10 | 729342 | .0234 |
| rs12712001 | 2 | .0001 | .000003 | BLNK | 10 | 29760 | .0234 |
| rs12712001 | 2 | .0001 | .000003 | NPM1 | 10 | 4869 | .0234 |
| rs12712001 | 2 | .0001 | .000003 | LOC399804 | 10 | 399804 | .0234 |
| rs1839049 | 3 | .00002 | .000002 | TMEM123 | 11 | 114908 | .0288 |
| rs9942049 | 3 | .0001 | .000001 | SPATA18 | 4 | 132671 | .0334 |
| rs10181725* | 2 | .00004 | .000002 | SOD3 | 4 | 6649 | .047 |
| rs10193059* | 2 | .00003 | .000003 | SOD3 | 4 | 6649 | .047 |
| Population/SNP . | Chromosome . | pQTL, P . | eQTL, P . | eQTL target gene . | Target gene chromosome . | Target gene ID . | Expression AUC, P . |
|---|---|---|---|---|---|---|---|
| CEU | |||||||
| rs17763463 | 2 | .00005 | .0000001 | GIT1 | 17 | 28964 | .00007 |
| rs7600852 | 2 | .00005 | .0000001 | GIT1 | 17 | 28964 | .00007 |
| rs17808412* | 3 | .00001 | .000001 | GIT1 | 17 | 28964 | .00007 |
| rs13358399 | 5 | .0001 | .000004 | C3orf6 | 152137 | .00008 | |
| rs2775139* | 13 | .000008 | .000001 | SLC25A37 | 8 | 51312 | .00069 |
| rs2775134 | 13 | .00002 | .000002 | SLC25A37 | 8 | 51312 | .00069 |
| rs1332944 | 13 | .00002 | .000002 | SLC25A37 | 8 | 51312 | .00069 |
| rs2585498 | 13 | .00002 | .000002 | SLC25A37 | 8 | 51312 | .00069 |
| rs2585499 | 13 | .00001 | .000003 | SLC25A37 | 8 | 51312 | .00069 |
| rs17795186* | 11 | .0001 | .000002 | P2RX1 | 17 | 5023 | .004 |
| rs17763463 | 2 | .00005 | .000001 | PTPRS | 19 | 5802 | .0102 |
| rs7600852 | 2 | .00005 | .000001 | PTPRS | 19 | 5802 | .0102 |
| rs368182* | 16 | .0001 | .000003 | CCDC24 | 1 | 149473 | .0426 |
| YRI | |||||||
| rs938562* | 4 | .0001 | .000003 | RPS6KA2 | 6 | 6196 | .00002 |
| rs16836417 | 1 | .0001 | .000001 | BMP3 | 4 | 651 | .00052 |
| rs16836421 | 1 | .0001 | .000001 | BMP3 | 4 | 651 | .00052 |
| rs16836403 | 1 | .0001 | .000001 | BMP3 | 4 | 651 | .00052 |
| rs11799391 | 1 | .0001 | .000001 | BMP3 | 4 | 651 | .00052 |
| rs4742299 | 9 | .00009 | .0000002 | DNAJB1 | 19 | 3337 | .00074 |
| rs4742299 | 9 | .00009 | .0000002 | MIST | 19 | 116449 | .00074 |
| rs11677428 | 2 | .00001 | .0000008 | LOC731990 | 1 | 731990 | .00123 |
| rs11677428 | 2 | .00001 | .0000008 | SDC3 | 1 | 9672 | .00123 |
| rs10973320 | 9 | .00002 | .00000004 | RAD51AP1 | 12 | 10635 | .00295 |
| rs10906723* | 10 | .0001 | .000002 | SSH2 | 17 | 85464 | .00549 |
| rs10906723* | 10 | .0001 | .000002 | LOC399491 | 17 | 399491 | .00549 |
| rs12225692 | 11 | .00009 | .000002 | NAB2 | 12 | 4665 | .00743 |
| rs16919696 | 8 | .00005 | .0000006 | CLDN16 | 3 | 10686 | .00846 |
| rs2430853* | 18 | .00001 | .0000004 | ANPEP | 15 | 290 | .017 |
| rs4634268 | 4 | .0001 | .000001 | ANPEP | 15 | 290 | .017 |
| rs10906723 | 10 | .0001 | .000002 | FAM78A | 9 | 286336 | .0174 |
| rs10461692 | 5 | .00008 | .000001 | FAM129A | 1 | 116496 | .0189 |
| rs11957363 | 5 | .0001 | .0000007 | FAM129A | 1 | 116496 | .0189 |
| rs17667845 | 5 | .0001 | .0000007 | FAM129A | 1 | 116496 | .0189 |
| rs17604706 | 5 | .0001 | .0000007 | FAM129A | 1 | 116496 | .0189 |
| rs1392421 | 5 | .0001 | .0000007 | FAM129A | 1 | 116496 | .0189 |
| rs6591904 | 11 | .0001 | .0000004 | BLVRB | 19 | 645 | .0223 |
| rs12712001 | 2 | .0001 | .000003 | ALK | 10 | 238 | .0234 |
| rs12712001 | 2 | .0001 | .000003 | LOC730467 | 10 | 730467 | .0234 |
| rs12712001 | 2 | .0001 | .000003 | LOC729342 | 10 | 729342 | .0234 |
| rs12712001 | 2 | .0001 | .000003 | BLNK | 10 | 29760 | .0234 |
| rs12712001 | 2 | .0001 | .000003 | NPM1 | 10 | 4869 | .0234 |
| rs12712001 | 2 | .0001 | .000003 | LOC399804 | 10 | 399804 | .0234 |
| rs1839049 | 3 | .00002 | .000002 | TMEM123 | 11 | 114908 | .0288 |
| rs9942049 | 3 | .0001 | .000001 | SPATA18 | 4 | 132671 | .0334 |
| rs10181725* | 2 | .00004 | .000002 | SOD3 | 4 | 6649 | .047 |
| rs10193059* | 2 | .00003 | .000003 | SOD3 | 4 | 6649 | .047 |
Included in the final multivariate model.