ADAMTS13 activity and antigen and carotid arterial occlusion time in HPC-transplanted mice
| . | Activity, % . | Antigen, μg/mL . | Occlusion time, min . | ||||
|---|---|---|---|---|---|---|---|
| 1 month . | 3 months . | 5 months . | 1 month . | 3 months . | 5 months . | ||
| HPC + GFP | |||||||
| O1 | 0 | n.d. | n.d. | 0 | n.d. | n.d. | 4.3 |
| O2 | 0 | n.d. | n.d. | 0 | n.d. | n.d. | 5.1 |
| O3 | 0 | n.d. | n.d. | 0 | n.d. | n.d. | 3.4 |
| O4 | 0 | n.d. | n.d. | 0 | n.d. | n.d. | 4.3 |
| R1 | 0 | n.d. | n.d. | 0 | n.d. | n.d. | 5.1 |
| R2 | 0 | n.d. | n.d. | 0 | n.d. | n.d. | 3.4 |
| R3 | 0 | n.d. | n.d. | 0 | n.d. | n.d. | n.d. |
| Mean ± SD | 0 ± 0 | 0 ± 0 | 4.3 ± 0.8 | ||||
| HPC + AD13 | |||||||
| N1 | 57.6 | 72.3 | 60.8 | 0.4 | 0.4 | 0.4 | 30.0 |
| N2 | 24.4 | 40.4 | 32.3 | 0.5 | 0.3 | 0.1 | 15.3 |
| N3 | 28.4 | 32.9 | 22.9 | 0.6 | 0.6 | 0.2 | 17.8 |
| P1 | 16.4 | 16.1 | 17.9 | 1.1 | 1.1 | 0.2 | 17.0 |
| P2 | 22.5 | 18.8 | 22.8 | 0.8 | 1.5 | 0.3 | 11.9 |
| P3 | 21.5 | 24.8 | 29.7 | 1.2 | 1.2 | 0.9 | 11.9 |
| P4 | 20.5 | 19.6 | 21.5 | 1.0 | 1.6 | 0.4 | 13.6 |
| Q1 | 9.2 | 7.9 | 14.1 | 0.3 | 0.4 | 0.5 | 6.8 |
| Q2 | 16.4 | 14.7 | 14.8 | 1.0 | 0.3 | 0.1 | n.d. |
| Mean ± SD | 24.1 ± 13.7 | 27.5 ± 19.4 | 26.3 ±14.3 | 0.8 ± 0.3 | 0.8 ± 0.5 | 0.4 ± 0.3 | 15.5 ± 6.8 |
| . | Activity, % . | Antigen, μg/mL . | Occlusion time, min . | ||||
|---|---|---|---|---|---|---|---|
| 1 month . | 3 months . | 5 months . | 1 month . | 3 months . | 5 months . | ||
| HPC + GFP | |||||||
| O1 | 0 | n.d. | n.d. | 0 | n.d. | n.d. | 4.3 |
| O2 | 0 | n.d. | n.d. | 0 | n.d. | n.d. | 5.1 |
| O3 | 0 | n.d. | n.d. | 0 | n.d. | n.d. | 3.4 |
| O4 | 0 | n.d. | n.d. | 0 | n.d. | n.d. | 4.3 |
| R1 | 0 | n.d. | n.d. | 0 | n.d. | n.d. | 5.1 |
| R2 | 0 | n.d. | n.d. | 0 | n.d. | n.d. | 3.4 |
| R3 | 0 | n.d. | n.d. | 0 | n.d. | n.d. | n.d. |
| Mean ± SD | 0 ± 0 | 0 ± 0 | 4.3 ± 0.8 | ||||
| HPC + AD13 | |||||||
| N1 | 57.6 | 72.3 | 60.8 | 0.4 | 0.4 | 0.4 | 30.0 |
| N2 | 24.4 | 40.4 | 32.3 | 0.5 | 0.3 | 0.1 | 15.3 |
| N3 | 28.4 | 32.9 | 22.9 | 0.6 | 0.6 | 0.2 | 17.8 |
| P1 | 16.4 | 16.1 | 17.9 | 1.1 | 1.1 | 0.2 | 17.0 |
| P2 | 22.5 | 18.8 | 22.8 | 0.8 | 1.5 | 0.3 | 11.9 |
| P3 | 21.5 | 24.8 | 29.7 | 1.2 | 1.2 | 0.9 | 11.9 |
| P4 | 20.5 | 19.6 | 21.5 | 1.0 | 1.6 | 0.4 | 13.6 |
| Q1 | 9.2 | 7.9 | 14.1 | 0.3 | 0.4 | 0.5 | 6.8 |
| Q2 | 16.4 | 14.7 | 14.8 | 1.0 | 0.3 | 0.1 | n.d. |
| Mean ± SD | 24.1 ± 13.7 | 27.5 ± 19.4 | 26.3 ±14.3 | 0.8 ± 0.3 | 0.8 ± 0.5 | 0.4 ± 0.3 | 15.5 ± 6.8 |
HPC indicates hematopoietic progenitor cell; GFP, green fluorescent protein; n.d., not determined; month, months after transplantation; SD, standard deviation; and AD13, ADAMTS13.