Table 1

Influence of castration and BMT on the development of EAE for days 0 to 42 after disease induction

EAE aloneEAE BMT aloneEAE Cx & BMT
Disease incidence 30/31 38/43 37/43 
Day of disease onset 10.5 (8-18) 13.8 (8-54) 13.0 (8-30) 
Death of severe disease 0/31 (0%) 3/43 (7%) 0/43 (0 %) 
Maximum clinical score 2.7 ± 0.6 2.2 ± 1.2 1.8 ± 1.4 
Cumulative clinical score 62.0 ± 20.3 32.38 ± 27.7 18.54 ± 15.7* 
Duration of disease, d 30.5 ± 4.9 17.3 ± 10.7 12.9 ± 10.6 
EAE aloneEAE BMT aloneEAE Cx & BMT
Disease incidence 30/31 38/43 37/43 
Day of disease onset 10.5 (8-18) 13.8 (8-54) 13.0 (8-30) 
Death of severe disease 0/31 (0%) 3/43 (7%) 0/43 (0 %) 
Maximum clinical score 2.7 ± 0.6 2.2 ± 1.2 1.8 ± 1.4 
Cumulative clinical score 62.0 ± 20.3 32.38 ± 27.7 18.54 ± 15.7* 
Duration of disease, d 30.5 ± 4.9 17.3 ± 10.7 12.9 ± 10.6 

Data are expressed as mean plus or minus SD.

*

P < .05 compared with BMT alone.

P < .001 compared with EAE alone.

Mann-Whitney U test.

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