Table 1

Hypothesized risk factors for inhibitor development

Patient-relatedTreatment-related
Race Number of fVIII exposure days 
Family history Age at first exposure to fVIII concentrates 
fVIII mutation Type of fVIII concentrate used 
MHC class Concurrent infection/inflammatory state 
Polymorphisms of immune-response genes (IL10, TNF, CTLA4) Intensive exposure to fVIII concentrates 
Patient-relatedTreatment-related
Race Number of fVIII exposure days 
Family history Age at first exposure to fVIII concentrates 
fVIII mutation Type of fVIII concentrate used 
MHC class Concurrent infection/inflammatory state 
Polymorphisms of immune-response genes (IL10, TNF, CTLA4) Intensive exposure to fVIII concentrates 
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