Patient characteristics and truncating NF1 mutations in pediatric T-ALL and AML
| ID . | Subtype . | Sex . | Age, y . | WBC, × 109/L . | Relapse or CCR, mo . | Genetic subtype . | Karyotype . | NF1 del . | NF1 mutation analysis . | |
|---|---|---|---|---|---|---|---|---|---|---|
| Exon . | Mutation . | |||||||||
| 2736 | T-ALL | M | 10.1 | 13 | Relapse, 15 | CALM-AF10 | 46, XY, t(2;9)(q21;q34),?t(8,8)(?q22;q?24) | Yes | 22 | c.3734delCinsGGTTTATGGTTT |
| Remission | — | — | — | — | — | — | 46, XY | No | — | WT |
| Relapse | — | — | — | — | — | — | 46, XY, t(2;9)(q21;q34),?t(8,8)(?q22;q?24) | Yes | 22 | c.3734delCinsGGTTTATGGTTT |
| 2780 | T-ALL | F | 5 | 140 | CCR, 50+ | TLX3 | 46, XX | Yes | 4 | c.333dupA |
| 167 | T-ALL | M | 16.4 | 170.9 | CCR, 56+ | Unknown | NA | Yes | — | WT |
| 4389 | AML | F | 18.8 | 41.7 | NA | MLL-AF9 | 46, XX, t(9;11)(p22;q23)[4]/46, XX [7] | Yes | 16 | c.2849 2850insTT |
| 6421 | 1AML | F | 6.5 | NA | Relapse, 68 | MLL-AF10 | 47, XX, t(10;11)(p13;q23),+19 | Yes | — | ND |
| ID . | Subtype . | Sex . | Age, y . | WBC, × 109/L . | Relapse or CCR, mo . | Genetic subtype . | Karyotype . | NF1 del . | NF1 mutation analysis . | |
|---|---|---|---|---|---|---|---|---|---|---|
| Exon . | Mutation . | |||||||||
| 2736 | T-ALL | M | 10.1 | 13 | Relapse, 15 | CALM-AF10 | 46, XY, t(2;9)(q21;q34),?t(8,8)(?q22;q?24) | Yes | 22 | c.3734delCinsGGTTTATGGTTT |
| Remission | — | — | — | — | — | — | 46, XY | No | — | WT |
| Relapse | — | — | — | — | — | — | 46, XY, t(2;9)(q21;q34),?t(8,8)(?q22;q?24) | Yes | 22 | c.3734delCinsGGTTTATGGTTT |
| 2780 | T-ALL | F | 5 | 140 | CCR, 50+ | TLX3 | 46, XX | Yes | 4 | c.333dupA |
| 167 | T-ALL | M | 16.4 | 170.9 | CCR, 56+ | Unknown | NA | Yes | — | WT |
| 4389 | AML | F | 18.8 | 41.7 | NA | MLL-AF9 | 46, XX, t(9;11)(p22;q23)[4]/46, XX [7] | Yes | 16 | c.2849 2850insTT |
| 6421 | 1AML | F | 6.5 | NA | Relapse, 68 | MLL-AF10 | 47, XX, t(10;11)(p13;q23),+19 | Yes | — | ND |
In additional mutation analysis, FLT3-ITD or D835 PM, C-KIT, RAS, and PTPN11 were all WT.
CCR indicates continued complete remission; —, not applicable; WT, wild-type; NA, not available; ND, not determined; PM, point mutation.