Allelic and genotypic distribution of the SNP rs1934951 and 3 additional SNPs allocated in the same gene rs1934980, rs1341162, and rs17110453
| SNP and variants . | Allele distribution . | P . | Pc . | *OR (CI 95%) . | Genotype . | Genotype distribution . | P . | ||
|---|---|---|---|---|---|---|---|---|---|
| Cases . | Controls . | Cases . | Controls . | ||||||
| rs1934951 | |||||||||
| C | 22/42 (52) | 112/128 (88) | 10−6 | .02 | CC | 4/21 (20) | 48/64 (75) | 2 × 10−6 | |
| T | 20/42 (48) | 16/128 (12) | 12.75 (3.7-43.5) | CT | 14/21 (66) | 16/64 (25) | |||
| TT | 3/21 (14) | ||||||||
| rs1934980 | |||||||||
| A | 23/42 | 113/128 | 4 × 10−6 | .09 | AA | 4/21 | 49/64 | 2 × 10−5 | |
| G | 19/42 | 15/128 | 13.88 (4.0-46.7) | AG | 15/21 | 15/64 | |||
| GG | 2/21 | ||||||||
| rs1341162 | |||||||||
| C | 22/44 | 109/130 | 6 × 10−6 | .13 | CC | 3/22 | 44/65 | 3 × 10−6 | |
| T | 22/44 | 21/130 | 13.27 (3.5-49.9) | CT | 16/22 | 21/65 | |||
| TT | 3/22 | ||||||||
| rs17110453 | |||||||||
| A | 25/44 | 112/128 | 2.2 × 10−5 | .46 | AA | 5/22 | 48/64 | 1.9 × 10−5 | |
| C | 19/44 | 16/128 | 10.2 (3.2-32.1) | AC | 15/22 | 16/64 | |||
| CC | 2/22 | ||||||||
| SNP and variants . | Allele distribution . | P . | Pc . | *OR (CI 95%) . | Genotype . | Genotype distribution . | P . | ||
|---|---|---|---|---|---|---|---|---|---|
| Cases . | Controls . | Cases . | Controls . | ||||||
| rs1934951 | |||||||||
| C | 22/42 (52) | 112/128 (88) | 10−6 | .02 | CC | 4/21 (20) | 48/64 (75) | 2 × 10−6 | |
| T | 20/42 (48) | 16/128 (12) | 12.75 (3.7-43.5) | CT | 14/21 (66) | 16/64 (25) | |||
| TT | 3/21 (14) | ||||||||
| rs1934980 | |||||||||
| A | 23/42 | 113/128 | 4 × 10−6 | .09 | AA | 4/21 | 49/64 | 2 × 10−5 | |
| G | 19/42 | 15/128 | 13.88 (4.0-46.7) | AG | 15/21 | 15/64 | |||
| GG | 2/21 | ||||||||
| rs1341162 | |||||||||
| C | 22/44 | 109/130 | 6 × 10−6 | .13 | CC | 3/22 | 44/65 | 3 × 10−6 | |
| T | 22/44 | 21/130 | 13.27 (3.5-49.9) | CT | 16/22 | 21/65 | |||
| TT | 3/22 | ||||||||
| rs17110453 | |||||||||
| A | 25/44 | 112/128 | 2.2 × 10−5 | .46 | AA | 5/22 | 48/64 | 1.9 × 10−5 | |
| C | 19/44 | 16/128 | 10.2 (3.2-32.1) | AC | 15/22 | 16/64 | |||
| CC | 2/22 | ||||||||
Distribution data for rs1934951 are number of variants/number in subgroup (%).
Pc indicates Bonferroni corrected P value.
The odds ratio was calculated assuming a dominant model of inheritance.