Genes containing SNPs with more than 1% minor allele frequency in the Marshfield population
| DMET metabolism . | DMET metabolism . | DMET metabolism . | DMET transport and other genes . | ||||
|---|---|---|---|---|---|---|---|
| Gene . | SNP count . | Gene . | SNP count . | Gene . | SNP count . | Gene . | SNP count . |
| ADH1B | 3 | CYP2C18 | 4 | GSTM4 | 2 | ABCB1 | 14 |
| ADH4 | 4 | CYP2C19 | 1 | GSTO1 | 1 | ABCB4 | 9 |
| ADH7 | 2 | CYP2D6 | 7 | GSTP1 | 3 | ABCB11 | 15 |
| ALDH1A1 | 1 | CYP2E1 | 7 | HNMT | 1 | ABCC1 | 10 |
| ALDH2 | 1 | CYP2F1 | 2 | MAOB | 1 | ABCC2 | 8 |
| ALDH3A1 | 2 | CYP2J2 | 1 | NAT1 | 7 | ABCC3 | 3 |
| AOX1 | 1 | CYP2S1 | 1 | NAT2 | 6 | ABCC4 | 12 |
| CDA | 2 | CYP39A1 | 2 | NQO1 | 4 | ABCC5 | 3 |
| CHST1 | 1 | CYP3A4 | 2 | POR | 1 | ABCC6 | 4 |
| CHST2 | 1 | CYP3A43 | 3 | PTGIS | 1 | ABCG2 | 1 |
| CHST3 | 13 | CYP3A5 | 1 | SULT1A1 | 1 | AHR | 2 |
| CHST5 | 4 | CYP3A7 | 1 | SULT1A2 | 1 | ATP7A | 1 |
| CHST7 | 1 | CYP4A11 | 1 | SULT1A3 | 1 | ATP7B | 10 |
| CHST10 | 5 | CYP4B1 | 6 | SULT1C1 | 1 | NR3C1 | 3 |
| CHST11 | 7 | CYP4F2 | 7 | SULT1C2 | 1 | PPARD | 38 |
| CHST13 | 2 | CYP4F8 | 4 | SULT1E1 | 2 | PPARG | 1 |
| CHST8 | 1 | CYP4F11 | 5 | SULT2A1 | 1 | RALBP1 | 3 |
| COMT | 2 | CYP4F12 | 4 | SULT2B1 | 2 | SLC10A1 | 1 |
| CYP11A1 | 1 | CYP4Z1 | 1 | SULT4A1 | 2 | SLC10A2 | 7 |
| CYP11B1 | 10 | CYP51A1 | 3 | TBXAS1 | 2 | SLC13A1 | 2 |
| CYP11B2 | 4 | CYP7A1 | 1 | TPMT | 3 | SLC15A1 | 5 |
| CYP17A1 | 3 | CYP8B1 | 1 | UGT1A1 | 5 | SLC15A2 | 5 |
| CYP19A1 | 5 | DPYD | 2 | UGT1A3 | 3 | SLC16A1 | 2 |
| CYP1A1 | 2 | EPHX1 | 7 | UGT1A4 | 1 | SLC19A1 | 2 |
| CYP1A2 | 6 | FMO1 | 4 | UGT1A6 | 2 | SLC22A1 | 7 |
| CYP1B1 | 1 | FMO2 | 10 | UGT1A7 | 1 | SLC22A2 | 2 |
| CYP20A1 | 2 | FMO3 | 6 | UGT2A1 | 2 | SLC22A3 | 2 |
| CYP24A1 | 4 | FMO5 | 1 | UGT2B4 | 2 | SLC22A4 | 3 |
| CYP2A13 | 3 | FMO6 | 4 | UGT2B11 | 1 | SLC22A5 | 3 |
| CYP2A6 | 13 | GSTA1 | 1 | UGT2B15 | 1 | SLC22A6 | 1 |
| CYP2A7 | 3 | GSTA2 | 4 | UGT2B28 | 1 | SLC22A8 | 2 |
| CYP2B6 | 8 | GSTA4 | 4 | UGT8 | 1 | SLC28A1 | 8 |
| CYP2C8 | 2 | GSTA5 | 1 | XDH | 4 | SLC28A2 | 1 |
| CYP2C9 | 2 | GSTM3 | 2 | SLC28A3 | 2 | ||
| SLC29A1 | 1 | ||||||
| SLC5A6 | 2 | ||||||
| SLC7A5 | 1 | ||||||
| SLC7A7 | 5 | ||||||
| SLCO1A2 | 3 | ||||||
| SLCO1B1 | 5 | ||||||
| SLCO1B3 | 4 | ||||||
| SLCO2B1 | 1 | ||||||
| SPG7 | 2 | ||||||
| DMET metabolism . | DMET metabolism . | DMET metabolism . | DMET transport and other genes . | ||||
|---|---|---|---|---|---|---|---|
| Gene . | SNP count . | Gene . | SNP count . | Gene . | SNP count . | Gene . | SNP count . |
| ADH1B | 3 | CYP2C18 | 4 | GSTM4 | 2 | ABCB1 | 14 |
| ADH4 | 4 | CYP2C19 | 1 | GSTO1 | 1 | ABCB4 | 9 |
| ADH7 | 2 | CYP2D6 | 7 | GSTP1 | 3 | ABCB11 | 15 |
| ALDH1A1 | 1 | CYP2E1 | 7 | HNMT | 1 | ABCC1 | 10 |
| ALDH2 | 1 | CYP2F1 | 2 | MAOB | 1 | ABCC2 | 8 |
| ALDH3A1 | 2 | CYP2J2 | 1 | NAT1 | 7 | ABCC3 | 3 |
| AOX1 | 1 | CYP2S1 | 1 | NAT2 | 6 | ABCC4 | 12 |
| CDA | 2 | CYP39A1 | 2 | NQO1 | 4 | ABCC5 | 3 |
| CHST1 | 1 | CYP3A4 | 2 | POR | 1 | ABCC6 | 4 |
| CHST2 | 1 | CYP3A43 | 3 | PTGIS | 1 | ABCG2 | 1 |
| CHST3 | 13 | CYP3A5 | 1 | SULT1A1 | 1 | AHR | 2 |
| CHST5 | 4 | CYP3A7 | 1 | SULT1A2 | 1 | ATP7A | 1 |
| CHST7 | 1 | CYP4A11 | 1 | SULT1A3 | 1 | ATP7B | 10 |
| CHST10 | 5 | CYP4B1 | 6 | SULT1C1 | 1 | NR3C1 | 3 |
| CHST11 | 7 | CYP4F2 | 7 | SULT1C2 | 1 | PPARD | 38 |
| CHST13 | 2 | CYP4F8 | 4 | SULT1E1 | 2 | PPARG | 1 |
| CHST8 | 1 | CYP4F11 | 5 | SULT2A1 | 1 | RALBP1 | 3 |
| COMT | 2 | CYP4F12 | 4 | SULT2B1 | 2 | SLC10A1 | 1 |
| CYP11A1 | 1 | CYP4Z1 | 1 | SULT4A1 | 2 | SLC10A2 | 7 |
| CYP11B1 | 10 | CYP51A1 | 3 | TBXAS1 | 2 | SLC13A1 | 2 |
| CYP11B2 | 4 | CYP7A1 | 1 | TPMT | 3 | SLC15A1 | 5 |
| CYP17A1 | 3 | CYP8B1 | 1 | UGT1A1 | 5 | SLC15A2 | 5 |
| CYP19A1 | 5 | DPYD | 2 | UGT1A3 | 3 | SLC16A1 | 2 |
| CYP1A1 | 2 | EPHX1 | 7 | UGT1A4 | 1 | SLC19A1 | 2 |
| CYP1A2 | 6 | FMO1 | 4 | UGT1A6 | 2 | SLC22A1 | 7 |
| CYP1B1 | 1 | FMO2 | 10 | UGT1A7 | 1 | SLC22A2 | 2 |
| CYP20A1 | 2 | FMO3 | 6 | UGT2A1 | 2 | SLC22A3 | 2 |
| CYP24A1 | 4 | FMO5 | 1 | UGT2B4 | 2 | SLC22A4 | 3 |
| CYP2A13 | 3 | FMO6 | 4 | UGT2B11 | 1 | SLC22A5 | 3 |
| CYP2A6 | 13 | GSTA1 | 1 | UGT2B15 | 1 | SLC22A6 | 1 |
| CYP2A7 | 3 | GSTA2 | 4 | UGT2B28 | 1 | SLC22A8 | 2 |
| CYP2B6 | 8 | GSTA4 | 4 | UGT8 | 1 | SLC28A1 | 8 |
| CYP2C8 | 2 | GSTA5 | 1 | XDH | 4 | SLC28A2 | 1 |
| CYP2C9 | 2 | GSTM3 | 2 | SLC28A3 | 2 | ||
| SLC29A1 | 1 | ||||||
| SLC5A6 | 2 | ||||||
| SLC7A5 | 1 | ||||||
| SLC7A7 | 5 | ||||||
| SLCO1A2 | 3 | ||||||
| SLCO1B1 | 5 | ||||||
| SLCO1B3 | 4 | ||||||
| SLCO2B1 | 1 | ||||||
| SPG7 | 2 | ||||||
DMET indicates drug-metabolizing enzymes and transporters; and SNP, single nucleotide polymorphism.