Table 5

Final odds of VWF based on the combination of LR from bleeding score, VWF: Ag level, and number of family members with VWF lower than the 2.5 percentile

VWF:Ag, IU/dLBleeding score
01234566 or more
1 family member with VWF lower than 2.5 pctl*         
    Less than 20 0.15 0.79 1.14 3.55 4.34 19.91 31.89 158.70 
    20 to 40 0.04 0.20 0.29 0.90 1.10 5.06 8.11 40.35 
    40 to 60 0.00 0.00 0.01 0.02 0.02 0.10 0.16 0.77 
    60 or more 0.00 0.00 0.00 0.00 0.00 0.01 0.01 0.04 
2 family members with VWF lower than 2.5 pctl*         
    Less than 20 4.06 21.36 30.58 95.50 116.87 536.17 858.70 4272.58 
    20 to 40 1.03 5.43 7.78 24.28 29.72 136.34 218.35 1086.42 
    40 to 60 0.02 0.10 0.15 0.46 0.57 2.61 4.18 20.79 
    60 or more 0.00 0.01 0.01 0.03 0.03 0.14 0.23 1.14 
3 family members with VWF lower than 2.5 pctl*         
    Less than 20 76.73 403.42 577.44 1803.50 2206.92 10124.93 16215.71 80683.02 
    20 to 40 19.51 102.58 146.83 458.59 561.17 2574.55 4123.30 20515.92 
    40 to 60 0.37 1.96 2.81 8.78 10.74 49.27 78.91 392.63 
    60 or more 0.02 0.11 0.15 0.48 0.59 2.71 4.34 21.57 
4 family members with VWF lower than 2.5 pctl*         
    Less than 20 276.55 1454.01 2081.23 6500.28 7954.30 36492.83 58445.54 290802.20 
    20 to 40 70.32 369.72 529.21 1652.88 2022.60 9279.33 14861.42 73944.62 
    40 to 60 1.35 7.08 10.13 31.63 38.71 177.59 284.41 1415.13 
    60 or more 0.07 0.39 0.56 1.74 2.13 9.76 15.63 77.75 
VWF:Ag, IU/dLBleeding score
01234566 or more
1 family member with VWF lower than 2.5 pctl*         
    Less than 20 0.15 0.79 1.14 3.55 4.34 19.91 31.89 158.70 
    20 to 40 0.04 0.20 0.29 0.90 1.10 5.06 8.11 40.35 
    40 to 60 0.00 0.00 0.01 0.02 0.02 0.10 0.16 0.77 
    60 or more 0.00 0.00 0.00 0.00 0.00 0.01 0.01 0.04 
2 family members with VWF lower than 2.5 pctl*         
    Less than 20 4.06 21.36 30.58 95.50 116.87 536.17 858.70 4272.58 
    20 to 40 1.03 5.43 7.78 24.28 29.72 136.34 218.35 1086.42 
    40 to 60 0.02 0.10 0.15 0.46 0.57 2.61 4.18 20.79 
    60 or more 0.00 0.01 0.01 0.03 0.03 0.14 0.23 1.14 
3 family members with VWF lower than 2.5 pctl*         
    Less than 20 76.73 403.42 577.44 1803.50 2206.92 10124.93 16215.71 80683.02 
    20 to 40 19.51 102.58 146.83 458.59 561.17 2574.55 4123.30 20515.92 
    40 to 60 0.37 1.96 2.81 8.78 10.74 49.27 78.91 392.63 
    60 or more 0.02 0.11 0.15 0.48 0.59 2.71 4.34 21.57 
4 family members with VWF lower than 2.5 pctl*         
    Less than 20 276.55 1454.01 2081.23 6500.28 7954.30 36492.83 58445.54 290802.20 
    20 to 40 70.32 369.72 529.21 1652.88 2022.60 9279.33 14861.42 73944.62 
    40 to 60 1.35 7.08 10.13 31.63 38.71 177.59 284.41 1415.13 
    60 or more 0.07 0.39 0.56 1.74 2.13 9.76 15.63 77.75 

Final odds from 2.0 to 10.0 in italic; final odds higher than 10 in bold. Odds could be converted into probabilities of disease with the formula probability=odds/(odds+1).

*

Total family size = 4. Proband included.

View Large
This Feature Is Available To Subscribers Only

or Create an Account

Close Modal
Close Modal