Pooled odds ratios (OR) and 95% confidence intervals (CI) by NHL subtype for TNFRSF5 −1C>T (rs1883832), TNFSF5 3005G>A (rs715762) and TNFSF5 6809 G>A (rs3092933) SNPs in the San Francisco Bay Area NHL1, NHL2, and German studies
| . | Controls, N (%) . | Cases, N (%) . | |||||
|---|---|---|---|---|---|---|---|
| All NHL . | OR (CI) . | DLBCL . | OR (CI) . | FL . | OR (CI) . | ||
| TNFRSF5 – 1C>T (rs1883832) | 2481 (100) | 1775 (100) | — | 520 (100) | — | 394 (100) | — |
| −1 CC | 1382 (56) | 933 (53) | 1.0 | 277 (53) | 1.0 | 188 (48) | 1.0 |
| −1 CT | 932 (38) | 695 (39) | 1.1 (0.97-1.3) | 199 (38) | 1.1 (0.87-1.3) | 168 (43) | 1.3 (1.1-1.7) |
| −1 TT | 166 (6.7) | 147 (8.2) | 1.3 (1.0-1.7) | 44 (8.5) | 1.3 (0.90-1.9) | 37 (9.4) | 1.6 (1.1-2.4) |
| CT/TT | 1098 (44) | 842 (47) | 1.1 (1.0-1.3) | 243 (47) | 1.1 (0.91-1.3) | 205 (52) | 1.4 (1.1-1.7) |
| P for trend* | — | — | .20 | — | 0.54 | — | .02 |
| TNFSF5 3005G>A (rs715762) | |||||||
| Men | 1402 | 1010 | — | 287 | — | 186 | — |
| 3005 G | 1262 (90) | 901 (89) | 1.0 | 256 (89) | 1.0 | 163 (88) | 1.0 |
| 3005 A | 140 (10) | 109 (11) | 1.1 (0.83-1.4) | 31 (11) | 1.1 (0.70-1.7) | 23 (12) | 1.3 (.76-2.1) |
| Women | 981 | 744 | — | 230 | — | 203 | — |
| 3005 GG | 790 (81) | 609 (82) | 1.0 | 186 (81) | 1.0 | 167 (82) | 1.0 |
| 3005 AG | 170 (12) | 119 (16) | 1.6 (1.2-2.1) | 40 (17) | 1.5 (1.0-2.4) | 31 (15) | 1.4 (.86-2.1) |
| 3005 AA | 21 (2.1) | 16 (2.1) | 0.99 (0.48-2.0) | 4 (1.7) | 0.81 (0.20-2.4) | 5 (2.5) | 1.1 (.33-3.1) |
| 3005 AG/AA | 191 (19) | 135 (18) | 0.92 (0.71-1.2) | 44 (19) | 0.77 (0.66-1.4) | 36 (18) | 0.89 (0.58-1.3) |
| TNFSF5 6809 G>A (rs3092933) | |||||||
| Men | 1399 | 1006 | — | 285 | — | 186 | — |
| 6809 G | 1276 (99) | 923 (92) | 1.0 | 265 (93) | 1.0 | 173 (93) | 1.0 |
| 6809 A | 123 (8.8) | 83 (8.4) | 0.93 (0.69-1.3) | 20 (7.0) | 0.78 (0.45-1.3) | 13 (6.7) | 0.78 (0.39-1.4) |
| Women | 984 | 744 | — | 226 | — | 205 | — |
| 6809 GG | 813 (83) | 640 (86) | 1.0 | 188 (83) | 1.0 | 182 (89) | 1.0 |
| 6809 AG | 159 (16) | 99 (13) | 0.78 (0.59-1.0) | 38 (17) | 1.0 (0.67-1.5) | 23 (11) | 0.65 (0.39-1.0) |
| 6809 AA | 10 (1.0) | 5 (.67) | 0.45 (0.13-1.3) | 0 | — | 0 | — |
| 6809 AG/AA | 169 (17) | 104 (14) | 0.75 (0.57-0.99) | 38 (17) | 0.94 (0.62-1.4) | 23 (11) | 0.61 (0.36-0.98) |
| . | Controls, N (%) . | Cases, N (%) . | |||||
|---|---|---|---|---|---|---|---|
| All NHL . | OR (CI) . | DLBCL . | OR (CI) . | FL . | OR (CI) . | ||
| TNFRSF5 – 1C>T (rs1883832) | 2481 (100) | 1775 (100) | — | 520 (100) | — | 394 (100) | — |
| −1 CC | 1382 (56) | 933 (53) | 1.0 | 277 (53) | 1.0 | 188 (48) | 1.0 |
| −1 CT | 932 (38) | 695 (39) | 1.1 (0.97-1.3) | 199 (38) | 1.1 (0.87-1.3) | 168 (43) | 1.3 (1.1-1.7) |
| −1 TT | 166 (6.7) | 147 (8.2) | 1.3 (1.0-1.7) | 44 (8.5) | 1.3 (0.90-1.9) | 37 (9.4) | 1.6 (1.1-2.4) |
| CT/TT | 1098 (44) | 842 (47) | 1.1 (1.0-1.3) | 243 (47) | 1.1 (0.91-1.3) | 205 (52) | 1.4 (1.1-1.7) |
| P for trend* | — | — | .20 | — | 0.54 | — | .02 |
| TNFSF5 3005G>A (rs715762) | |||||||
| Men | 1402 | 1010 | — | 287 | — | 186 | — |
| 3005 G | 1262 (90) | 901 (89) | 1.0 | 256 (89) | 1.0 | 163 (88) | 1.0 |
| 3005 A | 140 (10) | 109 (11) | 1.1 (0.83-1.4) | 31 (11) | 1.1 (0.70-1.7) | 23 (12) | 1.3 (.76-2.1) |
| Women | 981 | 744 | — | 230 | — | 203 | — |
| 3005 GG | 790 (81) | 609 (82) | 1.0 | 186 (81) | 1.0 | 167 (82) | 1.0 |
| 3005 AG | 170 (12) | 119 (16) | 1.6 (1.2-2.1) | 40 (17) | 1.5 (1.0-2.4) | 31 (15) | 1.4 (.86-2.1) |
| 3005 AA | 21 (2.1) | 16 (2.1) | 0.99 (0.48-2.0) | 4 (1.7) | 0.81 (0.20-2.4) | 5 (2.5) | 1.1 (.33-3.1) |
| 3005 AG/AA | 191 (19) | 135 (18) | 0.92 (0.71-1.2) | 44 (19) | 0.77 (0.66-1.4) | 36 (18) | 0.89 (0.58-1.3) |
| TNFSF5 6809 G>A (rs3092933) | |||||||
| Men | 1399 | 1006 | — | 285 | — | 186 | — |
| 6809 G | 1276 (99) | 923 (92) | 1.0 | 265 (93) | 1.0 | 173 (93) | 1.0 |
| 6809 A | 123 (8.8) | 83 (8.4) | 0.93 (0.69-1.3) | 20 (7.0) | 0.78 (0.45-1.3) | 13 (6.7) | 0.78 (0.39-1.4) |
| Women | 984 | 744 | — | 226 | — | 205 | — |
| 6809 GG | 813 (83) | 640 (86) | 1.0 | 188 (83) | 1.0 | 182 (89) | 1.0 |
| 6809 AG | 159 (16) | 99 (13) | 0.78 (0.59-1.0) | 38 (17) | 1.0 (0.67-1.5) | 23 (11) | 0.65 (0.39-1.0) |
| 6809 AA | 10 (1.0) | 5 (.67) | 0.45 (0.13-1.3) | 0 | — | 0 | — |
| 6809 AG/AA | 169 (17) | 104 (14) | 0.75 (0.57-0.99) | 38 (17) | 0.94 (0.62-1.4) | 23 (11) | 0.61 (0.36-0.98) |
Odds ratios (OR) and 95% confidence intervals (CI) were estimated using unconditional logistic regression adjusted for age and sex.
NHL indicates non-Hodgkin lymphoma; DLBCL, diffuse large B-cell lymphoma; FL, follicular lymphoma; and —, not applicable.
Linear trend estimated from age- and sex-adjusted logistic models where genotype was analyzed as an ordinal variable based on the number of variant alleles (0, 1, 2).