Summary of hematocrits (%) for GATA-1-surv mice
| . | Age, mo . | ||||||
|---|---|---|---|---|---|---|---|
| 2 . | 3 . | 4 . | 6 . | 8 . | 10 . | 12 . | |
| wt | 48 ± 3.3 | 49.5 ± 3.8 | 42.6 ± 4.7 | 44.3 ± 2.6 | 40.9 ± 9.6 | 44.1 ± 2.7 | 42.4 ± 3.0 |
| tg | 47.2 ± 2.4 | 45.1 ± 3.7 | 44.3 ± 3.2 | 44.6 ± 2.6 | 42.4 ± 4.5 | 42.2 ± 2.5 | 43.2 ± 3.4 |
| P | 0.59 | 0.05 | 0.47 | 0.88 | 0.73 | 0.21 | 0.65 |
| . | Age, mo . | ||||||
|---|---|---|---|---|---|---|---|
| 2 . | 3 . | 4 . | 6 . | 8 . | 10 . | 12 . | |
| wt | 48 ± 3.3 | 49.5 ± 3.8 | 42.6 ± 4.7 | 44.3 ± 2.6 | 40.9 ± 9.6 | 44.1 ± 2.7 | 42.4 ± 3.0 |
| tg | 47.2 ± 2.4 | 45.1 ± 3.7 | 44.3 ± 3.2 | 44.6 ± 2.6 | 42.4 ± 4.5 | 42.2 ± 2.5 | 43.2 ± 3.4 |
| P | 0.59 | 0.05 | 0.47 | 0.88 | 0.73 | 0.21 | 0.65 |
Summary of mean hematocrit (%; ± SD) for GATA-1-surv transgenic (tg) and wild-type (wt) mice over the course of 1 year (n = 7 mice per group). No statistical differences were found between the 2 groups except at the 3-month time point, which displayed a statistical significance of P = .0485 (unpaired, 2-tailed Student t test). Overall, we interpreted these results to demonstrate that survivin overexpression in GATA-1-surv mice had no effect on hematocrit levels.