Ingenuity pathway analysis predicts differentially expressed canonical signaling pathways across the differentiated lineages of MSCs
| Pathways . | Sample ID . | |||||
|---|---|---|---|---|---|---|
| A07 . | A14 . | C07 . | C14 . | O07 . | O14 . | |
| Axonal guidance signaling | 3.67 | 7.4 | — | 2.16 | 1.81 | 1.42 |
| Complement and coagulation cascades | 2.28 | — | 1.7 | — | 1.77 | 1.73 |
| EGF signaling | 2.51 | 3.27 | 1.98 | — | 2.47 | — |
| ERK/MAPK signaling | 3.02 | 4.02 | 1.98 | 1.89 | 2.98 | 1.54 |
| Integrin signaling | 3.22 | 5.31 | 2.86 | 1.96 | 1.47 | — |
| Interferon signaling | — | 1.31 | 3.25 | — | 1.70 | 1.67 |
| Leukocyte extravasation signaling | 2.19 | 1.47 | — | 1.93 | 1.63 | 1.56 |
| PDGF signaling | 1.58 | 2.12 | 3.17 | 1.82 | 1.65 | — |
| TGF-β signaling | — | 2.00 | 2.28 | 3.82 | 2.29 | — |
| Pathways . | Sample ID . | |||||
|---|---|---|---|---|---|---|
| A07 . | A14 . | C07 . | C14 . | O07 . | O14 . | |
| Axonal guidance signaling | 3.67 | 7.4 | — | 2.16 | 1.81 | 1.42 |
| Complement and coagulation cascades | 2.28 | — | 1.7 | — | 1.77 | 1.73 |
| EGF signaling | 2.51 | 3.27 | 1.98 | — | 2.47 | — |
| ERK/MAPK signaling | 3.02 | 4.02 | 1.98 | 1.89 | 2.98 | 1.54 |
| Integrin signaling | 3.22 | 5.31 | 2.86 | 1.96 | 1.47 | — |
| Interferon signaling | — | 1.31 | 3.25 | — | 1.70 | 1.67 |
| Leukocyte extravasation signaling | 2.19 | 1.47 | — | 1.93 | 1.63 | 1.56 |
| PDGF signaling | 1.58 | 2.12 | 3.17 | 1.82 | 1.65 | — |
| TGF-β signaling | — | 2.00 | 2.28 | 3.82 | 2.29 | — |
Data are −log(P values). Pathways with −log(P value) greater than 1.3 (P < .05) in at least one sample (day 7 or day 14) were considered to be statistically differentially expressed in MSC differentiation. These pathways are predicted to be important in MSC differentiation to all 3 lineages. Since FGF signaling pathway was not significantly enriched in any sample, it is not represented in this table.
— indicates not available.