Clinical and biologic features of the CLL patients studied
| Patient no. . | Age, y . | Sex . | Clinical course . | Stage* . | IGHV,† % . | CD38, % . | ZAP-70 . | Follow-up, mo . | Death‡ . | pERK . |
|---|---|---|---|---|---|---|---|---|---|---|
| 56 | 58 | M | Progressive | 0/A | 97.9 | 40.7 | nd | 144 | no | Pos |
| 29 | 62 | M | Progressive | 0/A | 100 | 81 | Pos | 40 | yes | Pos |
| 46 | 44 | F | Progressive | 0/A | 100 | 4 | Pos | 30 | no | Pos |
| 14 | 74 | M | Stable | 0/A | 87.7 | 3.0 | Pos | 95 | no | Pos |
| 1 | 79 | M | Progressive | 0/A | 100.0 | 41 | Pos | 97 | yes | Pos |
| 4 | 69 | F | Stable | 0/A | 96.7 | 0.7 | Pos | 84 | nd | Pos |
| 3 | 76 | M | Progressive | 0/A | 99.0 | 74 | Neg | 101 | no | Pos |
| 11 | 61 | M | Progressive | 0/A | 89.5 | 1.0 | Pos | 182 | no | Pos |
| 6 | 62 | M | Progressive | 0/A | 94.7 | 0.4 | Neg | 73 | no | Pos |
| 12 | 78 | F | Stable | 0/A | 89.5 | 0.4 | Neg | 101 | no | Pos |
| 10 | 80 | F | Progressive | 0/A | 91.2 | 0.4 | Neg | 222 | no | Pos |
| 5 | 68 | F | Progressive | 0/A | 94.9 | 0.3 | Neg | 91 | no | Pos |
| 9 | 50 | M | Progressive | 0/A | 93.3 | 1.5 | Pos | 105 | no | Pos |
| 13 | 72 | F | Stable | 0/A | 88.4 | 0.1 | Pos | 53 | no | Pos |
| 45 | 83 | F | Progressive | 0/A | 97.6 | 86.0 | Neg | 97 | no | Pos |
| 8 | 68 | M | Progressive | 0/A | 93.5 | 0.4 | Pos | 163 | no | Pos |
| 2 | 76 | F | Progressive | 0/A | 99.0 | 38 | Pos | 54 | no | Pos |
| 7 | 70 | M | Stable | 0/A | 93.7 | 29 | Pos | 49 | no | Pos |
| 15 | 85 | F | Progressive | 1/B | 99.34 | 0.5 | Pos | 44 | no | Pos |
| 16 | 53 | M | Progressive | 1/B | 96.2 | 0.1 | Neg | 159 | no | Pos |
| 44 | 65 | M | Stable | 1/B | 95.4 | 0.1 | nd | 132 | no | Pos |
| 19 | 80 | F | Progressive | 2/B | 98.6 | 28 | Pos | 82 | no | Pos |
| 17 | 74 | M | Progressive | 2/B | 92.5 | 1.0 | Pos | 125 | no | Pos |
| 18 | 53 | M | Progressive | 2/B | 96.2 | 0.1 | Pos | 48 | yes | Pos |
| 55 | 59 | M | Progressive | 4/C | 100.0 | 22.0 | Pos | 63 | yes | Pos |
| 22 | 67 | F | Stable | 0/A | 91.8 | 0.2 | nd | 143 | no | Neg |
| 36 | 59 | F | Progressive | 0/A | 92 | nd | nd | 218 | no | Neg |
| 30 | 79 | M | Stable | 0/A | 92.0 | 0.3 | nd | 216 | no | Neg |
| 34 | 68 | F | Stable | 0/A | 99.31 | nd | nd | 10 | no | Neg |
| 53 | 56 | M | Stable | 0/A | 96.5 | 1.7 | Pos | 60 | no | Neg |
| 20 | 62 | F | Stable | 0/A | 99.7 | 3.7 | Pos | 44 | no | Neg |
| 40 | 75 | M | Stable | 0/A | 94.56 | 0.7 | nd | 16 | no | Neg |
| 21 | 55 | M | Progressive | 0/A | 95.3 | 0.3 | Neg | 107 | no | Neg |
| 37 | 78 | F | Progressive | 0/A | 100 | nd | Pos | 101 | yes | Neg |
| 51 | 58 | M | Stable | 1/B | 87.2 | nd | nd | 30 | no | Neg |
| 48 | 78 | M | Progressive | 1/B | 95.83 | 2.3 | Pos | 76 | no | Neg |
| 54 | 76 | F | Progressive | 1/B | 100 | 15.02 | Pos | 66 | no | Neg |
| 49 | 69 | F | Stable | 1/B | 100.0 | 3.5 | Pos | 6 | no | Neg |
| 42 | 62 | M | Progressive | 1/B | 99.6 | 0.1 | nd | nd | no | Neg |
| 47 | 66 | M | Progressive | 2/B | 91.5 | 5.9 | Neg | 84 | yes | Neg |
| 41 | 47 | F | Progressive | 2/B | 88.9 | nd | nd | 156 | no | Neg |
| 32 | 65 | M | Progressive | 2/B | 95.83 | 0.6 | Pos | 36 | no | Neg |
| 35 | 69 | M | Progressive | 2/B | 95 | 64 | Pos | 120 | yes | Neg |
| 50 | 68 | M | Progressive | 2/B | 100 | 7.4 | Pos | 96 | no | Neg |
| 23 | 82 | M | Progressive | 2/B | 99.0 | 60 | Pos | 162 | no | Neg |
| 24 | 76 | F | Progressive | 2/B | 98.6 | 100 | Pos | 13 | no | Neg |
| 26 | 66 | M | Progressive | 4/C | 100.0 | 99.0 | Pos | 107 | no | Neg |
| 27 | 72 | M | Progressive | 4/C | 96.6 | 16.0 | Neg | 81 | no | Neg |
| 52 | 66 | M | Progressive | nd | nd | 0.1 | Pos | nd | no | Neg |
| 43 | 69 | M | Progressive | nd | nd | 0.9 | Pos | 42 | no | Neg |
| 28 | 57 | M | nd | nd | 91.9 | nd | nd | nd | nd | Neg |
| Patient no. . | Age, y . | Sex . | Clinical course . | Stage* . | IGHV,† % . | CD38, % . | ZAP-70 . | Follow-up, mo . | Death‡ . | pERK . |
|---|---|---|---|---|---|---|---|---|---|---|
| 56 | 58 | M | Progressive | 0/A | 97.9 | 40.7 | nd | 144 | no | Pos |
| 29 | 62 | M | Progressive | 0/A | 100 | 81 | Pos | 40 | yes | Pos |
| 46 | 44 | F | Progressive | 0/A | 100 | 4 | Pos | 30 | no | Pos |
| 14 | 74 | M | Stable | 0/A | 87.7 | 3.0 | Pos | 95 | no | Pos |
| 1 | 79 | M | Progressive | 0/A | 100.0 | 41 | Pos | 97 | yes | Pos |
| 4 | 69 | F | Stable | 0/A | 96.7 | 0.7 | Pos | 84 | nd | Pos |
| 3 | 76 | M | Progressive | 0/A | 99.0 | 74 | Neg | 101 | no | Pos |
| 11 | 61 | M | Progressive | 0/A | 89.5 | 1.0 | Pos | 182 | no | Pos |
| 6 | 62 | M | Progressive | 0/A | 94.7 | 0.4 | Neg | 73 | no | Pos |
| 12 | 78 | F | Stable | 0/A | 89.5 | 0.4 | Neg | 101 | no | Pos |
| 10 | 80 | F | Progressive | 0/A | 91.2 | 0.4 | Neg | 222 | no | Pos |
| 5 | 68 | F | Progressive | 0/A | 94.9 | 0.3 | Neg | 91 | no | Pos |
| 9 | 50 | M | Progressive | 0/A | 93.3 | 1.5 | Pos | 105 | no | Pos |
| 13 | 72 | F | Stable | 0/A | 88.4 | 0.1 | Pos | 53 | no | Pos |
| 45 | 83 | F | Progressive | 0/A | 97.6 | 86.0 | Neg | 97 | no | Pos |
| 8 | 68 | M | Progressive | 0/A | 93.5 | 0.4 | Pos | 163 | no | Pos |
| 2 | 76 | F | Progressive | 0/A | 99.0 | 38 | Pos | 54 | no | Pos |
| 7 | 70 | M | Stable | 0/A | 93.7 | 29 | Pos | 49 | no | Pos |
| 15 | 85 | F | Progressive | 1/B | 99.34 | 0.5 | Pos | 44 | no | Pos |
| 16 | 53 | M | Progressive | 1/B | 96.2 | 0.1 | Neg | 159 | no | Pos |
| 44 | 65 | M | Stable | 1/B | 95.4 | 0.1 | nd | 132 | no | Pos |
| 19 | 80 | F | Progressive | 2/B | 98.6 | 28 | Pos | 82 | no | Pos |
| 17 | 74 | M | Progressive | 2/B | 92.5 | 1.0 | Pos | 125 | no | Pos |
| 18 | 53 | M | Progressive | 2/B | 96.2 | 0.1 | Pos | 48 | yes | Pos |
| 55 | 59 | M | Progressive | 4/C | 100.0 | 22.0 | Pos | 63 | yes | Pos |
| 22 | 67 | F | Stable | 0/A | 91.8 | 0.2 | nd | 143 | no | Neg |
| 36 | 59 | F | Progressive | 0/A | 92 | nd | nd | 218 | no | Neg |
| 30 | 79 | M | Stable | 0/A | 92.0 | 0.3 | nd | 216 | no | Neg |
| 34 | 68 | F | Stable | 0/A | 99.31 | nd | nd | 10 | no | Neg |
| 53 | 56 | M | Stable | 0/A | 96.5 | 1.7 | Pos | 60 | no | Neg |
| 20 | 62 | F | Stable | 0/A | 99.7 | 3.7 | Pos | 44 | no | Neg |
| 40 | 75 | M | Stable | 0/A | 94.56 | 0.7 | nd | 16 | no | Neg |
| 21 | 55 | M | Progressive | 0/A | 95.3 | 0.3 | Neg | 107 | no | Neg |
| 37 | 78 | F | Progressive | 0/A | 100 | nd | Pos | 101 | yes | Neg |
| 51 | 58 | M | Stable | 1/B | 87.2 | nd | nd | 30 | no | Neg |
| 48 | 78 | M | Progressive | 1/B | 95.83 | 2.3 | Pos | 76 | no | Neg |
| 54 | 76 | F | Progressive | 1/B | 100 | 15.02 | Pos | 66 | no | Neg |
| 49 | 69 | F | Stable | 1/B | 100.0 | 3.5 | Pos | 6 | no | Neg |
| 42 | 62 | M | Progressive | 1/B | 99.6 | 0.1 | nd | nd | no | Neg |
| 47 | 66 | M | Progressive | 2/B | 91.5 | 5.9 | Neg | 84 | yes | Neg |
| 41 | 47 | F | Progressive | 2/B | 88.9 | nd | nd | 156 | no | Neg |
| 32 | 65 | M | Progressive | 2/B | 95.83 | 0.6 | Pos | 36 | no | Neg |
| 35 | 69 | M | Progressive | 2/B | 95 | 64 | Pos | 120 | yes | Neg |
| 50 | 68 | M | Progressive | 2/B | 100 | 7.4 | Pos | 96 | no | Neg |
| 23 | 82 | M | Progressive | 2/B | 99.0 | 60 | Pos | 162 | no | Neg |
| 24 | 76 | F | Progressive | 2/B | 98.6 | 100 | Pos | 13 | no | Neg |
| 26 | 66 | M | Progressive | 4/C | 100.0 | 99.0 | Pos | 107 | no | Neg |
| 27 | 72 | M | Progressive | 4/C | 96.6 | 16.0 | Neg | 81 | no | Neg |
| 52 | 66 | M | Progressive | nd | nd | 0.1 | Pos | nd | no | Neg |
| 43 | 69 | M | Progressive | nd | nd | 0.9 | Pos | 42 | no | Neg |
| 28 | 57 | M | nd | nd | 91.9 | nd | nd | nd | nd | Neg |
pos indicates positive as determined by immunoblot analysis; neg, negative as determined by immunoblot analysis; and nd, not determined.
According to criteria previously described by Rai et al32 and Binet et al.31
Shown as percentage of similarity to the closest germ line gene.
Resulting from CLL-related events.