Summary of congenital defects identified following maternal exposure to imatinib (n = 12)
| Fetus no. . | Trimester exposure . | Pregnancy outcome . | Maternal age, y . | Imatinib dose (OD), mg . | Other medication . | Fetal abnormality . |
|---|---|---|---|---|---|---|
| 1 | First | Elective termination | 29 | 300 | None | Abnormal ultrasound, elevated AFP |
| 2 | All | Elective termination | 35 | NK | Warfarin, paracetamol, levofloxacin, lorazepam, heparin, prochlorperazine | Warfarin embryopathy: depressed nasal bridge, choanal stenosis, Dandy Walker cyst, ventricular septal defect, coarctation of the aorta, gastroschisis |
| 3 | Unknown | Elective termination | 37 | 400 | Omeprazole | Cleft palate, polydactyly |
| 4 | First | Stillbirth at 34 wk | 25 | 400 | Hydroxyurea after first trimester | Meningocoele |
| 5 | First | Live birth | 35 | 400 | Hydroxyurea | Premature closure of skull sutures |
| 6 | First | Live birth | Unknown | NK | None | Scoliosis, small exomphalos |
| 7 | First | Live birth, premature at week 30: baby died after 45 min | 25 | 400 | NK | Communicating hydrocephalus, cerebellar hypoplasia, atrial septal defect, overriding aorta, ascites, pericardial effusion |
| 8 | First | Live birth | 27 | 300 | Anagrelide and hydroxyurea (timing unknown) | Hypospadias |
| 9 | First | Live birth | 29 | 300 | None | Hypospadias |
| 10 | First | Live birth | 35 | 400 | Hydroxyurea after first trimester | Pyloric stenosis |
| 11 | First | Live birth | Unknown | 400 | None | Hypoplastic lungs, exomphalos, left duplex kidney, right absent kidney, hemivertebrae, and right shoulder anomaly |
| 12 | Unknown | Live birth (premature) | Unknown | 400 | Interferon | Exomphalos, right renal agenesis and hemivertebrae |
| Fetus no. . | Trimester exposure . | Pregnancy outcome . | Maternal age, y . | Imatinib dose (OD), mg . | Other medication . | Fetal abnormality . |
|---|---|---|---|---|---|---|
| 1 | First | Elective termination | 29 | 300 | None | Abnormal ultrasound, elevated AFP |
| 2 | All | Elective termination | 35 | NK | Warfarin, paracetamol, levofloxacin, lorazepam, heparin, prochlorperazine | Warfarin embryopathy: depressed nasal bridge, choanal stenosis, Dandy Walker cyst, ventricular septal defect, coarctation of the aorta, gastroschisis |
| 3 | Unknown | Elective termination | 37 | 400 | Omeprazole | Cleft palate, polydactyly |
| 4 | First | Stillbirth at 34 wk | 25 | 400 | Hydroxyurea after first trimester | Meningocoele |
| 5 | First | Live birth | 35 | 400 | Hydroxyurea | Premature closure of skull sutures |
| 6 | First | Live birth | Unknown | NK | None | Scoliosis, small exomphalos |
| 7 | First | Live birth, premature at week 30: baby died after 45 min | 25 | 400 | NK | Communicating hydrocephalus, cerebellar hypoplasia, atrial septal defect, overriding aorta, ascites, pericardial effusion |
| 8 | First | Live birth | 27 | 300 | Anagrelide and hydroxyurea (timing unknown) | Hypospadias |
| 9 | First | Live birth | 29 | 300 | None | Hypospadias |
| 10 | First | Live birth | 35 | 400 | Hydroxyurea after first trimester | Pyloric stenosis |
| 11 | First | Live birth | Unknown | 400 | None | Hypoplastic lungs, exomphalos, left duplex kidney, right absent kidney, hemivertebrae, and right shoulder anomaly |
| 12 | Unknown | Live birth (premature) | Unknown | 400 | Interferon | Exomphalos, right renal agenesis and hemivertebrae |
OD indicates once daily; AFP, alpha fetoprotein; and NK, not known.