Table 1 Biodistribution of 125 I-labeled... | American Society of Hematology

Table 1

Biodistribution of ¹²⁵I-labeled anti-PECAM/NCs versus IgG/NCs 30 minutes after intravenous injection in mice

	Blood	Brain	Kidney	Heart	Liver	Lung	Spleen
%ID/g
IgG/NCs	3.6 ± 0.2	0.4 ± 0.04	3.0 ± 0.3	2.1 ± 0.3	48.9 ± 2.9	10.2 ± 1.1	87.9 ± 8.4
Anti-PECAM/NCs	2.0 ± 0.7*	1.0 ± 0.1†	5.0 ± 0.3†	5.5 ± 0.5†	24.7 ± 1.8†	89.8 ± 13.8†	61.7 ± 5.2*
LR
IgG/NCs	—	0.1 ± 0.02	0.9 ± 0.1	0.6 ± 0.1	14.3 ± 1.5	2.9 ± 0.3	25.4 ± 2.9
Anti-PECAM/NCs	—	1.2 ± 0.3*	5.5 ± 1.2†	6.1 ± 1.4†	26.4 ± 5.7	107.8 ± 29.7†	64.3 ± 13.6
ISI: Anti-PECAM: IgG	—	9.6	6.4	9.9	1.8	36.7	2.5

	Blood	Brain	Kidney	Heart	Liver	Lung	Spleen
%ID/g
IgG/NCs	3.6 ± 0.2	0.4 ± 0.04	3.0 ± 0.3	2.1 ± 0.3	48.9 ± 2.9	10.2 ± 1.1	87.9 ± 8.4
Anti-PECAM/NCs	2.0 ± 0.7*	1.0 ± 0.1†	5.0 ± 0.3†	5.5 ± 0.5†	24.7 ± 1.8†	89.8 ± 13.8†	61.7 ± 5.2*
LR
IgG/NCs	—	0.1 ± 0.02	0.9 ± 0.1	0.6 ± 0.1	14.3 ± 1.5	2.9 ± 0.3	25.4 ± 2.9
Anti-PECAM/NCs	—	1.2 ± 0.3*	5.5 ± 1.2†	6.1 ± 1.4†	26.4 ± 5.7	107.8 ± 29.7†	64.3 ± 13.6
ISI: Anti-PECAM: IgG	—	9.6	6.4	9.9	1.8	36.7	2.5

Data are mean SEM; n ≥ 3.

ID/g indicates percent injected dose per gram of organ; LR, localization ratio (% ID/g in an organ: % ID/g in blood); ISI, immunospecificity index (LR for anti-PECAM/NCs: LR for IgG/NCs); and —, not applicable.

P < .05 (Student t test).

†

P < .01 (Student t test).

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