Frequency of LTK, FYN, JAK3, and TYK2 alleles and genotypes in AML and control populations
| Gene name and rsID . | Chr . | Position . | Variant . | Codon . | Controls . | AML . | P . | |||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| n . | AA . | AB . | BB . | n . | AA . | AB . | BB . | Allele . | Genotype . | |||||
| LTK | ||||||||||||||
| rs35932273 | 15 | 39585434 | G>A | D474N | 162 | 155 (0.96) | 7 (0.04) | 0 (0) | 188 | 179 (0.95) | 9 (0.05) | 0 (0) | 1 | 1 |
| novel | 15 | 39583644 | G>T | E813/752ter* | 188 | 185 (0.98) | 3 (0.02) | 0 (0) | 188 | 186 (0.99) | 2 (0.01) | 0 (0) | 1 | 1 |
| FYN | ||||||||||||||
| rs28763975 | 6 | 112089731 | C>G | D502/506E* | 138 | 133 (0.96) | 5 (0.04) | 0 (0) | 188 | 180 (0.96) | 8 (0.04) | 0 (0) | 1 | 1 |
| JAK3 | ||||||||||||||
| rs3212723 | 19 | 17815215 | C>A | P132T | 188 | 188 (1.0) | 0 (0) | 0 (0) | 188 | 183 (0.97) | 5 (0.03) | 0 (0) | .062 | .024 |
| TYK2 | ||||||||||||||
| rs34536443 | 19 | 10324118 | C>G | P1104A | 94 | 87 (0.93) | 7 (0.07) | 0 (0) | 188 | 175 (0.93) | 13 (0.07) | 0 (0) | 1 | 1 |
| rs35018800 | 19 | 10325843 | C>T | A928V | 176 | 172 (0.98) | 4 (0.02) | 0 (0) | 188 | 183 (0.97) | 5 (0.03) | 0 (0) | 1 | 1 |
| rs2304256 | 19 | 10336652 | G>T | V362F | 146 | 82 (0.56) | 53 (0.36) | 11(0.08) | 184 | 99 (0.54) | 71 (0.39) | 14 (0.08) | .79 | .91 |
| rs2304255 | 19 | 10336649 | G>A | G363S | 147 | 120 (0.82) | 27 (0.18) | 0 (0) | 188 | 177 (0.94) | 10 (0.05) | 1 (0.01) | .0013 | .006† |
| Gene name and rsID . | Chr . | Position . | Variant . | Codon . | Controls . | AML . | P . | |||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| n . | AA . | AB . | BB . | n . | AA . | AB . | BB . | Allele . | Genotype . | |||||
| LTK | ||||||||||||||
| rs35932273 | 15 | 39585434 | G>A | D474N | 162 | 155 (0.96) | 7 (0.04) | 0 (0) | 188 | 179 (0.95) | 9 (0.05) | 0 (0) | 1 | 1 |
| novel | 15 | 39583644 | G>T | E813/752ter* | 188 | 185 (0.98) | 3 (0.02) | 0 (0) | 188 | 186 (0.99) | 2 (0.01) | 0 (0) | 1 | 1 |
| FYN | ||||||||||||||
| rs28763975 | 6 | 112089731 | C>G | D502/506E* | 138 | 133 (0.96) | 5 (0.04) | 0 (0) | 188 | 180 (0.96) | 8 (0.04) | 0 (0) | 1 | 1 |
| JAK3 | ||||||||||||||
| rs3212723 | 19 | 17815215 | C>A | P132T | 188 | 188 (1.0) | 0 (0) | 0 (0) | 188 | 183 (0.97) | 5 (0.03) | 0 (0) | .062 | .024 |
| TYK2 | ||||||||||||||
| rs34536443 | 19 | 10324118 | C>G | P1104A | 94 | 87 (0.93) | 7 (0.07) | 0 (0) | 188 | 175 (0.93) | 13 (0.07) | 0 (0) | 1 | 1 |
| rs35018800 | 19 | 10325843 | C>T | A928V | 176 | 172 (0.98) | 4 (0.02) | 0 (0) | 188 | 183 (0.97) | 5 (0.03) | 0 (0) | 1 | 1 |
| rs2304256 | 19 | 10336652 | G>T | V362F | 146 | 82 (0.56) | 53 (0.36) | 11(0.08) | 184 | 99 (0.54) | 71 (0.39) | 14 (0.08) | .79 | .91 |
| rs2304255 | 19 | 10336649 | G>A | G363S | 147 | 120 (0.82) | 27 (0.18) | 0 (0) | 188 | 177 (0.94) | 10 (0.05) | 1 (0.01) | .0013 | .006† |