Cytoplasmic tyrosine kinase (CTK) and receptor tyrosine kinase (RTK) genes resequenced in primary AML patient samples
| Set . | Gene name . | Locus ID . | Total no. of exons . | No. of exons covered (discovery tumor) . | No. of amplicons sequenced (discovery tumor) . | No. of amplicons sequenced (discovery germline) . | No. of amplicons sequenced (CALGB) . |
|---|---|---|---|---|---|---|---|
| CTK | ABL1 | 25 | 10 | 6 | 6 | 2 | 1 |
| CTK | BTK | 695 | 19 | 6 | 6 | 0 | 0 |
| RTK | CSF1R | 1436 | 22 | 11 | 15 | 5 | 0 |
| CTK | CSK | 1445 | 12 | 8 | 19 | 0 | 0 |
| RTK | DDR1 | 780 | 19 | 6 | 8 | 5 | 1 |
| RTK | EPHB1 | 2047 | 16 | 7 | 8 | 2 | 0 |
| CTK | FES | 2242 | 19 | 7 | 6 | 1 | 1 |
| RTK | FGFR1 | 2260 | 18 | 8 | 7 | 2 | 0 |
| CTK | FGR | 2268 | 11 | 6 | 4 | 0 | 0 |
| RTK | FLT3 | 2322 | 24 | 2 | 5 | 2 | 2 |
| CTK | FYN | 2534 | 11 | 7 | 7 | 0 | 1 |
| CTK | HCK | 3055 | 13 | 6 | 6 | 2 | 2 |
| RTK | IGF1R | 3480 | 21 | 6 | 7 | 0 | 0 |
| RTK | INSR | 3643 | 22 | 6 | 10 | 3 | 0 |
| CTK | JAK1 | 3716 | 24 | 24 | 33 | 33 | 33 |
| CTK | JAK2 | 3717 | 25 | 14 | 20 | 10 | 1 |
| CTK | JAK3 | 3718 | 23 | 15 | 16 | 2 | 2 |
| RTK | KIT | 3815 | 21 | 2 | 2 | 2 | 1 |
| RTK | LTK | 4058 | 20 | 10 | 10 | 7 | 3 |
| CTK | LYN | 4067 | 13 | 6 | 22 | 1 | 1 |
| RTK | NTRK1 | 4914 | 17 | 5 | 7 | 4 | 3 |
| CTK | PTK2B | 2185 | 36 | 8 | 8 | 0 | 0 |
| RTK | RYK | 6259 | 14 | 8 | 8 | 0 | 0 |
| CTK | SYK | 6850 | 14 | 6 | 6 | 0 | 0 |
| CTK | TYK2 | 7297 | 25 | 23 | 33 | 7 | 9 |
| CTK | YES1 | 7525 | 11 | 6 | 7 | 0 | 0 |
| Total | 480 | 219 | 286 | 90 | 61 |
| Set . | Gene name . | Locus ID . | Total no. of exons . | No. of exons covered (discovery tumor) . | No. of amplicons sequenced (discovery tumor) . | No. of amplicons sequenced (discovery germline) . | No. of amplicons sequenced (CALGB) . |
|---|---|---|---|---|---|---|---|
| CTK | ABL1 | 25 | 10 | 6 | 6 | 2 | 1 |
| CTK | BTK | 695 | 19 | 6 | 6 | 0 | 0 |
| RTK | CSF1R | 1436 | 22 | 11 | 15 | 5 | 0 |
| CTK | CSK | 1445 | 12 | 8 | 19 | 0 | 0 |
| RTK | DDR1 | 780 | 19 | 6 | 8 | 5 | 1 |
| RTK | EPHB1 | 2047 | 16 | 7 | 8 | 2 | 0 |
| CTK | FES | 2242 | 19 | 7 | 6 | 1 | 1 |
| RTK | FGFR1 | 2260 | 18 | 8 | 7 | 2 | 0 |
| CTK | FGR | 2268 | 11 | 6 | 4 | 0 | 0 |
| RTK | FLT3 | 2322 | 24 | 2 | 5 | 2 | 2 |
| CTK | FYN | 2534 | 11 | 7 | 7 | 0 | 1 |
| CTK | HCK | 3055 | 13 | 6 | 6 | 2 | 2 |
| RTK | IGF1R | 3480 | 21 | 6 | 7 | 0 | 0 |
| RTK | INSR | 3643 | 22 | 6 | 10 | 3 | 0 |
| CTK | JAK1 | 3716 | 24 | 24 | 33 | 33 | 33 |
| CTK | JAK2 | 3717 | 25 | 14 | 20 | 10 | 1 |
| CTK | JAK3 | 3718 | 23 | 15 | 16 | 2 | 2 |
| RTK | KIT | 3815 | 21 | 2 | 2 | 2 | 1 |
| RTK | LTK | 4058 | 20 | 10 | 10 | 7 | 3 |
| CTK | LYN | 4067 | 13 | 6 | 22 | 1 | 1 |
| RTK | NTRK1 | 4914 | 17 | 5 | 7 | 4 | 3 |
| CTK | PTK2B | 2185 | 36 | 8 | 8 | 0 | 0 |
| RTK | RYK | 6259 | 14 | 8 | 8 | 0 | 0 |
| CTK | SYK | 6850 | 14 | 6 | 6 | 0 | 0 |
| CTK | TYK2 | 7297 | 25 | 23 | 33 | 7 | 9 |
| CTK | YES1 | 7525 | 11 | 6 | 7 | 0 | 0 |
| Total | 480 | 219 | 286 | 90 | 61 |