Effect of sorafenib on cytokine secretion by DCs
| Cytokine . | No sorafenib . | Sorafenib concentration . | ||
|---|---|---|---|---|
| 1 μg/mL . | 3 μg/mL . | 5 μg/mL . | ||
| IL-12, pg/mL | 767 | 342 | 40 | 9 |
| IL-10, pg/mL | 325 | 425 | 88 | 82 |
| TNF-α, pg/mL | >10 000 | >10 000 | 4633 | 2824 |
| IL-6, pg/mL | 9758 | >10 000 | 7130 | 6546 |
| Cytokine . | No sorafenib . | Sorafenib concentration . | ||
|---|---|---|---|---|
| 1 μg/mL . | 3 μg/mL . | 5 μg/mL . | ||
| IL-12, pg/mL | 767 | 342 | 40 | 9 |
| IL-10, pg/mL | 325 | 425 | 88 | 82 |
| TNF-α, pg/mL | >10 000 | >10 000 | 4633 | 2824 |
| IL-6, pg/mL | 9758 | >10 000 | 7130 | 6546 |
Secretion of IL-12, IL-10, IL-6, and TNF-α was determined in the supernatant of cultured DCs treated with sorafenib and stimulated with LPS using commercially available ELISAs.