Chromosomal abnormalities detected by iFISH in B-CLPD subtypes
| B-CLPD/gene . | Chromosomal abnormality . | Probe . |
|---|---|---|
| B-CLL | ||
| MDM2?39 | trisomy 12 | CEP12* |
| RB1/D13S2540 | del(13q) | LSI 13/RB1 (13q14)/LSI D13S25 (13q14.3)* |
| ATM/MLL40,41 | del(11q) | LSI ATM (11q22.3)/LSI MLL (11q23.3)* |
| P5340 | del(17p) | LSI P53 (17p13.1)* |
| MCL | ||
| CYCLIN D142,43 | t(11;14) | LSI IGH/CCND1* |
| MALT | ||
| MLT144,45 | t(18q21) | LSI MALT1* |
| IGH | t(14q32) | LSI IGH* |
| FL, BCL243,46 | t(14;18) | LSI IGH/BCL2* |
| DLBCL, BCL647 | t(3q27) | LSI BCL6* |
| BL, C-MYC48 | t(8;14) | LSI IGH/MYC/CEP8* |
| LPL/WM | ||
| IGH49 | t(14q32) | LSI IGH* |
| BLIMP150,51 | del(6q21) | 6q21 cocktail probe† |
| B-CLPD/gene . | Chromosomal abnormality . | Probe . |
|---|---|---|
| B-CLL | ||
| MDM2?39 | trisomy 12 | CEP12* |
| RB1/D13S2540 | del(13q) | LSI 13/RB1 (13q14)/LSI D13S25 (13q14.3)* |
| ATM/MLL40,41 | del(11q) | LSI ATM (11q22.3)/LSI MLL (11q23.3)* |
| P5340 | del(17p) | LSI P53 (17p13.1)* |
| MCL | ||
| CYCLIN D142,43 | t(11;14) | LSI IGH/CCND1* |
| MALT | ||
| MLT144,45 | t(18q21) | LSI MALT1* |
| IGH | t(14q32) | LSI IGH* |
| FL, BCL243,46 | t(14;18) | LSI IGH/BCL2* |
| DLBCL, BCL647 | t(3q27) | LSI BCL6* |
| BL, C-MYC48 | t(8;14) | LSI IGH/MYC/CEP8* |
| LPL/WM | ||
| IGH49 | t(14q32) | LSI IGH* |
| BLIMP150,51 | del(6q21) | 6q21 cocktail probe† |
B-CLPD indicates B-cell chronic lymphoproliferative disorders; B-CLL, B-cell chronic lymphocytic leukemia; MCL, mantle-cell lymphoma; MALT, mucosa-associated lymphoid tissue lymphoma; FL, follicular lymphoma; DLBCL, diffuse large B-cell lymphoma; BL, Burkitt lymphoma; and LPL/WM, lymphoplasmacytic lymphoma/Waldenström macroglobulinemia.
Vysis.
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