Table 2 Results of intracellular... | American Society of Hematology

Table 2

Results of intracellular cytokine analysis

Variable	Baseline	3 mo			6 mo	12 mo	Controls, N = 30
Variable	ITP all pts, N = 30	ITP all pts, N = 30	Responders, N = 14	Nonresponders, N = 16	Responders, N = 14	Responders, N = 9	Controls, N = 30
Th1, × 10⁹/L	0.23 ± 0.10	0.24 ± 0.13	0.24 ± 0.14	0.24 ± 0.13	0.24 ± 0.14	0.22 ± 0.12	0.25 ± 0.08
Th1, %	16.3 ± 5.3	15.2 ± 6.1	14.6 ± 5.3	15.8 ± 6.9	15.7 ± 6.8	15.3 ± 6.4	15.9 ± 2.6
Th2, × 10⁹/L	0.018 ± 0.008	0.29 ± 0.017*	0.038 ± 0.017*	0.021 ± 0.011	0.039 ± 0.018*	0.032 ± 0.015*	0.035 ± 0.013*
Th2, %	1.4 ± 0.6	1.9 ± 0.9*	2.5 ± 0.9*	1.3 ± 0.6	2.6 ± 1.0*	2.4 ± 0.8*	2.3 ± 0.5*
Th1/Th2	19.1 ± 13.5	13.3 ± 6.4	10.9 ± 9.8*	15.9 ± 13.6	7.1 ± 5.8*	8.2 ± 3.6*	7.5 ± 2.1*
Tc1, × 10⁹/L	0.38 ± 0.17	0.33 ± 0.11	0.32 ± 0.11	0.33 ± 0.11	0.29 ± 0.10	0.32 ± 0.12	0.36 ± 0.11
Tc1, %	26.2 ± 7.4	21.2 ± 3.8	20.4 ± 3.9	21.8 ± 3.7	19.1 ± 4.1	22.4 ± 3.3	23.4 ± 3.0
Tc2, × 10⁹/L	0.011 ± 0.004	0.021 ± 0.011*	0.025 ± 0.012*	0.017 ± 0.007	0.030 ± 0.12*	0.028 ± 0.010*	0.034 ± 0.013*
Tc2, %	0.8 ± 0.3	1.4 ± 0.6*	1.6 ± 0.6*	1.1 ± 0.4	2.0 ± 0.4*	1.9 ± 0.5*	2.2 ± 0.6*
Tc1/Tc2	34.0 ± 14.2	18.4 ± 8.4*	15.1 ± 8.1*	21.3 ± 7.8*	10.0 ± 2.8*	11.8 ± 0.7*	11.0 ± 2.7*

Variable	Baseline	3 mo			6 mo	12 mo	Controls, N = 30
Variable	ITP all pts, N = 30	ITP all pts, N = 30	Responders, N = 14	Nonresponders, N = 16	Responders, N = 14	Responders, N = 9	Controls, N = 30
Th1, × 10⁹/L	0.23 ± 0.10	0.24 ± 0.13	0.24 ± 0.14	0.24 ± 0.13	0.24 ± 0.14	0.22 ± 0.12	0.25 ± 0.08
Th1, %	16.3 ± 5.3	15.2 ± 6.1	14.6 ± 5.3	15.8 ± 6.9	15.7 ± 6.8	15.3 ± 6.4	15.9 ± 2.6
Th2, × 10⁹/L	0.018 ± 0.008	0.29 ± 0.017*	0.038 ± 0.017*	0.021 ± 0.011	0.039 ± 0.018*	0.032 ± 0.015*	0.035 ± 0.013*
Th2, %	1.4 ± 0.6	1.9 ± 0.9*	2.5 ± 0.9*	1.3 ± 0.6	2.6 ± 1.0*	2.4 ± 0.8*	2.3 ± 0.5*
Th1/Th2	19.1 ± 13.5	13.3 ± 6.4	10.9 ± 9.8*	15.9 ± 13.6	7.1 ± 5.8*	8.2 ± 3.6*	7.5 ± 2.1*
Tc1, × 10⁹/L	0.38 ± 0.17	0.33 ± 0.11	0.32 ± 0.11	0.33 ± 0.11	0.29 ± 0.10	0.32 ± 0.12	0.36 ± 0.11
Tc1, %	26.2 ± 7.4	21.2 ± 3.8	20.4 ± 3.9	21.8 ± 3.7	19.1 ± 4.1	22.4 ± 3.3	23.4 ± 3.0
Tc2, × 10⁹/L	0.011 ± 0.004	0.021 ± 0.011*	0.025 ± 0.012*	0.017 ± 0.007	0.030 ± 0.12*	0.028 ± 0.010*	0.034 ± 0.013*
Tc2, %	0.8 ± 0.3	1.4 ± 0.6*	1.6 ± 0.6*	1.1 ± 0.4	2.0 ± 0.4*	1.9 ± 0.5*	2.2 ± 0.6*
Tc1/Tc2	34.0 ± 14.2	18.4 ± 8.4*	15.1 ± 8.1*	21.3 ± 7.8*	10.0 ± 2.8*	11.8 ± 0.7*	11.0 ± 2.7*

T-cell subset values are expressed as both absolute concentrations (× 10⁹/L) and as percentage of CD3⁺ cells (%). Data are shown as mean plus or minus a standard deviation.

Statistically significant (P < .05) difference compared with baseline.

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