IRs of thrombosis for different groups of studies according to the overall population included
| . | No. studies . | No. cohorts . | No. patients . | No. events . | IR, % (95% CI) . |
|---|---|---|---|---|---|
| Lymphoma patients* | 5 | 8 | 15 397 | 922 | 6.0 (5.6-6.4) |
| Lymphoma patients† | 5 | 12 | 1222 | 99 | 8.1 (6.6-9.9) |
| Only non-Hodgkin lymphoma (NHL)‡ | 3 | 4 | 189 | 22 | 11.6 (7.6-17.6) |
| Only high-grade NHL | 3 | 3 | 991 | 71 | 7.2 (5.7-9.0) |
| Only Hodgkin lymphoma | 1 | 1 | 177 | 10 | 5.6 (3.0-10.5) |
| Only central nervous system lymphoma | 1 | 1 | 42 | 25 | 59.5 (40.2-88.1) |
| Total | 18 | 29 | 18 018 | 1149 | 6.4 (6.0-6.8) |
| . | No. studies . | No. cohorts . | No. patients . | No. events . | IR, % (95% CI) . |
|---|---|---|---|---|---|
| Lymphoma patients* | 5 | 8 | 15 397 | 922 | 6.0 (5.6-6.4) |
| Lymphoma patients† | 5 | 12 | 1222 | 99 | 8.1 (6.6-9.9) |
| Only non-Hodgkin lymphoma (NHL)‡ | 3 | 4 | 189 | 22 | 11.6 (7.6-17.6) |
| Only high-grade NHL | 3 | 3 | 991 | 71 | 7.2 (5.7-9.0) |
| Only Hodgkin lymphoma | 1 | 1 | 177 | 10 | 5.6 (3.0-10.5) |
| Only central nervous system lymphoma | 1 | 1 | 42 | 25 | 59.5 (40.2-88.1) |
| Total | 18 | 29 | 18 018 | 1149 | 6.4 (6.0-6.8) |
P < .001 for difference among groups of studies.
Studies in which the authors included patients with different cancers, with subsequent description of thrombotic events by type of malignancy, including lymphoma. Three of these differentiate NHL from HL, whereas 2 do not discriminate type of lymphoma. Numbers of patients and events refer to lymphoma cases.
Studies which included only lymphoma patients. Three studies differentiate NHL from HL and discriminated subtypes of NHL, whereas 2 do not discriminate type of lymphoma.
One of the studies discriminates low-grade NHL from high-grade NHL.