Table 1 Summary of AML patient... | American Society of Hematology

Table 1

Summary of AML patient characteristics

AML	PB/BM	% CD34	Flt3-ITD	p-Stat5	FAB	Risk group	Karyotype	Transduced	CD34⁺ cells plated per T25	Growth until wk	Expansion after Renilla RNAi	Expansion after Stat5 RNAi	Fold down-regulation
1	PB	85	−	+	M1	Poor	+3q,−7, −10	No	N/A	N/A	N/A	N/A	N/A
2	PB	3	−	−	M1	Int	Normal	No	N/A	N/A	N/A	N/A	N/A
3	PB	14	−	+	M2	Good	t(8;21)	No	N/A	N/A	N/A	N/A	N/A
4	PB	15	−	+	M4	Poor	t(6;11)(q27;23)	No	N/A	N/A	N/A	N/A	N/A
5	PB	69	+	±	M5	Int	Normal	Yes	1.5 × 10⁵	6	25.0	15.6	1.6
6	BM	5	+	−	M5b	Int	Normal	Yes	2.2 × 10⁵	4	4.2	5.7	0.7
7	PB	12	+	+	M5	Int	Normal	Yes	1.5 × 10⁵	6	9.7	4.0	2.4
8	PB	1	+	+	M5	Int	Normal	Yes	1.5 × 10⁵	6	8.1	2.4	3.4
9	BM	nd	−	−	M4	Int	Normal	Yes	5.0 × 10⁵	6	214.2	12.7	16.8
10	BM	80	+	+	M1	Good	inv(16)	Yes	5.0 × 10⁵	6	17.7	0.7	24.4
11	BM	5	−	+	M4	Poor	inv(16)	Yes	5.0 × 10⁵	6	207.1	67.1	3.1
12	BM	37	nd	nd	M4	Int	Normal	Yes	2.2 × 10⁵	4	7.6	1.6	4.8
13	PB	17	+	nd	M2	Poor	del 9, (q12;22)	Yes	1.5 × 10⁵	2, then †	N/A	N/A	N/A
14	BM	nd	−	−	M2	Int	Normal	Yes	5.0 × 10⁵	2, then †	N/A	N/A	N/A
15	PB	7	+	−	M5b	Int	Normal	No	N/A	N/A	N/A	N/A	N/A
16	PB	30	+	nd	M1	Int	Normal	Yes	N/A	N/A	N/A	N/A	N/A

AML	PB/BM	% CD34	Flt3-ITD	p-Stat5	FAB	Risk group	Karyotype	Transduced	CD34⁺ cells plated per T25	Growth until wk	Expansion after Renilla RNAi	Expansion after Stat5 RNAi	Fold down-regulation
1	PB	85	−	+	M1	Poor	+3q,−7, −10	No	N/A	N/A	N/A	N/A	N/A
2	PB	3	−	−	M1	Int	Normal	No	N/A	N/A	N/A	N/A	N/A
3	PB	14	−	+	M2	Good	t(8;21)	No	N/A	N/A	N/A	N/A	N/A
4	PB	15	−	+	M4	Poor	t(6;11)(q27;23)	No	N/A	N/A	N/A	N/A	N/A
5	PB	69	+	±	M5	Int	Normal	Yes	1.5 × 10⁵	6	25.0	15.6	1.6
6	BM	5	+	−	M5b	Int	Normal	Yes	2.2 × 10⁵	4	4.2	5.7	0.7
7	PB	12	+	+	M5	Int	Normal	Yes	1.5 × 10⁵	6	9.7	4.0	2.4
8	PB	1	+	+	M5	Int	Normal	Yes	1.5 × 10⁵	6	8.1	2.4	3.4
9	BM	nd	−	−	M4	Int	Normal	Yes	5.0 × 10⁵	6	214.2	12.7	16.8
10	BM	80	+	+	M1	Good	inv(16)	Yes	5.0 × 10⁵	6	17.7	0.7	24.4
11	BM	5	−	+	M4	Poor	inv(16)	Yes	5.0 × 10⁵	6	207.1	67.1	3.1
12	BM	37	nd	nd	M4	Int	Normal	Yes	2.2 × 10⁵	4	7.6	1.6	4.8
13	PB	17	+	nd	M2	Poor	del 9, (q12;22)	Yes	1.5 × 10⁵	2, then †	N/A	N/A	N/A
14	BM	nd	−	−	M2	Int	Normal	Yes	5.0 × 10⁵	2, then †	N/A	N/A	N/A
15	PB	7	+	−	M5b	Int	Normal	No	N/A	N/A	N/A	N/A	N/A
16	PB	30	+	nd	M1	Int	Normal	Yes	N/A	N/A	N/A	N/A	N/A

PB indicates peripheral blood; BM, bone marrow; Flt3-ITD, Flt3 internal tandem duplication; FAB, French-American-British; nd, not determined; +, present; −, not present; and N/A, not applicable.