Different inflammatory biomarkers in relation to SNP rs12075
| Biomarker . | n . | Median (25th to 75th percentile) . | β . | SE . | 95% CI . | P . |
|---|---|---|---|---|---|---|
| ARIC, plasma | ||||||
| RANTES, pg/mL | 1114 | 5996 (2006-10 259) | 0.039 | 0.073 | −0.10 to 0.18 | .59 |
| FHS, serum | ||||||
| Intercellular adhesion molecule-1* | 6897 | 241.0 (208.9-285.9) | 0.007 | 0.005 | −0.004 to 0.017 | .20 |
| Interleukin-6* | 3042 | 2.71 (1.82-4.31) | −0.011 | 0.020 | −0.050 to 0.028 | .59 |
| Myeloperoxidase* | 2941 | 39.95 (27.76-59.41) | −0.028 | 0.017 | −0.061 to 0.004 | .09 |
| MONICA/KORA subcohort, serum | ||||||
| C-reactive protein* | 1453 | 1.47 (0.66-3.21) | −0.014 | 0.044 | −0.101 to 0.073 | .76 |
| Intercellular adhesion molecule-1 | 1436 | 728.9 (590.4-902.4) | 13.11 | 11.43 | −9.29 to 35.51 | .25 |
| Interferon-inducible protein-10* | 1423 | 220.3 (144.4-357.0) | −0.024 | 0.032 | −0.086 to 0.039 | .46 |
| Interleukin-6* | 1432 | 2.35 (1.41-3.80) | −0.057 | 0.044 | −0.142 to 0.029 | .194 |
| Interleukin-8*† | 1424 | 6.9 (5.0-9.8) | −0.068 | 0.025 | −0.117 to −0.019 | .007 |
| Interleukin-18* | 1424 | 171.4 (113.2-243.3) | −0.034 | 0.031 | −0.095 to 0.028 | .284 |
| Macrophage migration inhibitory factor* | 1379 | 18.0 (14.5-22.8) | −0.018 | 0.015 | −0.047 to 0.010 | .21 |
| MCP-1*† | 1424 | 201.6 (126.1-312.1) | −0.28 | 0.03 | −0.35 to −0.22 | 2.2 * 10−16 |
| Myeloperoxidase* | 1268 | 120.0 (94.2-154.0) | −0.006 | 0.016 | −0.038 to 0.026 | .70 |
| RANTES*† | 1380 | 22 844 (14 938-35 604) | −0.068 | 0.022 | −0.111 to −0.025 | .002 |
| Biomarker . | n . | Median (25th to 75th percentile) . | β . | SE . | 95% CI . | P . |
|---|---|---|---|---|---|---|
| ARIC, plasma | ||||||
| RANTES, pg/mL | 1114 | 5996 (2006-10 259) | 0.039 | 0.073 | −0.10 to 0.18 | .59 |
| FHS, serum | ||||||
| Intercellular adhesion molecule-1* | 6897 | 241.0 (208.9-285.9) | 0.007 | 0.005 | −0.004 to 0.017 | .20 |
| Interleukin-6* | 3042 | 2.71 (1.82-4.31) | −0.011 | 0.020 | −0.050 to 0.028 | .59 |
| Myeloperoxidase* | 2941 | 39.95 (27.76-59.41) | −0.028 | 0.017 | −0.061 to 0.004 | .09 |
| MONICA/KORA subcohort, serum | ||||||
| C-reactive protein* | 1453 | 1.47 (0.66-3.21) | −0.014 | 0.044 | −0.101 to 0.073 | .76 |
| Intercellular adhesion molecule-1 | 1436 | 728.9 (590.4-902.4) | 13.11 | 11.43 | −9.29 to 35.51 | .25 |
| Interferon-inducible protein-10* | 1423 | 220.3 (144.4-357.0) | −0.024 | 0.032 | −0.086 to 0.039 | .46 |
| Interleukin-6* | 1432 | 2.35 (1.41-3.80) | −0.057 | 0.044 | −0.142 to 0.029 | .194 |
| Interleukin-8*† | 1424 | 6.9 (5.0-9.8) | −0.068 | 0.025 | −0.117 to −0.019 | .007 |
| Interleukin-18* | 1424 | 171.4 (113.2-243.3) | −0.034 | 0.031 | −0.095 to 0.028 | .284 |
| Macrophage migration inhibitory factor* | 1379 | 18.0 (14.5-22.8) | −0.018 | 0.015 | −0.047 to 0.010 | .21 |
| MCP-1*† | 1424 | 201.6 (126.1-312.1) | −0.28 | 0.03 | −0.35 to −0.22 | 2.2 * 10−16 |
| Myeloperoxidase* | 1268 | 120.0 (94.2-154.0) | −0.006 | 0.016 | −0.038 to 0.026 | .70 |
| RANTES*† | 1380 | 22 844 (14 938-35 604) | −0.068 | 0.022 | −0.111 to −0.025 | .002 |
Models were age- and sex-adjusted, MONICA/KORA additionally adjusted for survey.
Biomarkers were log-transformed for analysis of relation to rs12075.
Significant associations (P < .05) were identified for inflammatory biomarkers with a Darc strong-binding chemokine profile, but not for other serum inflammatory markers.