Table 2

Findings with genome-wide association

Serum
Plasma
FHSMONICA/KORAMeta-analysisARICMONICA/KORAMeta-analysis
Chromosome 1 locus (rs12075, missense (Asp42Gly), A/G, DARC, physical position 157441978)       
    Age- and sex-adjusted       
        β Estimate, SE −0.23, 0.006 −0.25, 0.014 −0.23, 0.006 −0.002, 0.013 −0.002, 0.013 −0.002, 0.009 
        P 4.5 * 10−321 1.5 * 10−73 < 1.0 * 10−323 .87 .85 .82 
        MAF, % 45.5 46.3 45.6 47.6 46.3 47.0 
    Multivariable-adjusted       
        β Estimate, SE −0.23, 0.006 −0.25, 0.014 0.23, 0.006 0.001, 0.013 0.002, 0.013 0.001, 0.009 
        P < 1.0 * 10−323 1.53 * 10−73 < 1.0 * 10−323 .99 .88 .91 
Chromosome 3 locus (rs12495098, unknown function, G/T, CCR2; CCR3, physical position 46317506)       
    Age- and sex-adjusted       
        β Estimate, SE 0.11, 0.013 0.12, 0.024 0.11, 0.012 0.06, 0.024 0.10, 0.022 0.08, 0.016 
        P 9.7 * 10−16 5.6 * 10−7 1.1 * 10−20 .011 5.7 * 10−6 3.7 * 10−7 
        MAF, % 8.7 8.4 8.6 7.7 8.4 8.1 
    Multivariable-adjusted       
        β Estimate, SE 0.11, 0.013 0.12, 0.024 0.11, 0.012 0.06, 0.023 0.10, 0.022 0.08, 0.016 
        P 1.9 * 10−16 5.6 * 10−7 1.7 * 10−21 .01 4.5 * 10−6 3.3 * 10−7 
Chromosome 3 locus (rs10510751, unknown function, G/T, CCR2; CCR3, physical position 46321029)       
    Age- and sex-adjusted       
        β Estimate, SE 0.11, 0.013 0.12, 0.024 −0.11, 0.012 0.06, 0.023 0.10, 0.022 0.08, 0.016 
        P 8.9 * 10−16 6.1 * 10−7 1.2 * 10−20 .011 5.7 * 10−6 3.7 * 10−7 
        MAF, % 8.7 8.3 8.6 7.8 8.3 8.1 
    Multivariable-adjusted       
        β Estimate, SE 0.11, 0.013 0.12, 0.024 0.11, 0.012 0.06, 0.023 0.10, 0.022 0.08, 0.016 
        P 1.7 * 10−16 6.1 * 10−7 1.9 * 10−21 .01 4.5 * 10−6 4.0 * 10−7 
Chromosome 2 locus (rs7601375, T/C, intronic, COBLL1, physical position 46317506)       
    Age- and sex-adjusted       
        β Estimate, SE −0.01, 0.006 −0.006, 0.013 −0.01, 0.006 −0.04, 0.012 −0.04, 0.012 −0.04, 0.009 
        P .07 .65 .07 .0007 .0004 7.8 * 10−7 
        MAF, % 40.8 40.0 40.1 39.7 40.0 39.9 
    Multivariable-adjusted       
        β Estimate, SE −0.01, 0.006 −0.006, 0.013 −0.01, 0.006 −0.04, 0.012 −0.04, 0.012 −0.04, 0.009 
        P .07 .65 .07 .0004 .0006 9.6 * 10−7 
Serum
Plasma
FHSMONICA/KORAMeta-analysisARICMONICA/KORAMeta-analysis
Chromosome 1 locus (rs12075, missense (Asp42Gly), A/G, DARC, physical position 157441978)       
    Age- and sex-adjusted       
        β Estimate, SE −0.23, 0.006 −0.25, 0.014 −0.23, 0.006 −0.002, 0.013 −0.002, 0.013 −0.002, 0.009 
        P 4.5 * 10−321 1.5 * 10−73 < 1.0 * 10−323 .87 .85 .82 
        MAF, % 45.5 46.3 45.6 47.6 46.3 47.0 
    Multivariable-adjusted       
        β Estimate, SE −0.23, 0.006 −0.25, 0.014 0.23, 0.006 0.001, 0.013 0.002, 0.013 0.001, 0.009 
        P < 1.0 * 10−323 1.53 * 10−73 < 1.0 * 10−323 .99 .88 .91 
Chromosome 3 locus (rs12495098, unknown function, G/T, CCR2; CCR3, physical position 46317506)       
    Age- and sex-adjusted       
        β Estimate, SE 0.11, 0.013 0.12, 0.024 0.11, 0.012 0.06, 0.024 0.10, 0.022 0.08, 0.016 
        P 9.7 * 10−16 5.6 * 10−7 1.1 * 10−20 .011 5.7 * 10−6 3.7 * 10−7 
        MAF, % 8.7 8.4 8.6 7.7 8.4 8.1 
    Multivariable-adjusted       
        β Estimate, SE 0.11, 0.013 0.12, 0.024 0.11, 0.012 0.06, 0.023 0.10, 0.022 0.08, 0.016 
        P 1.9 * 10−16 5.6 * 10−7 1.7 * 10−21 .01 4.5 * 10−6 3.3 * 10−7 
Chromosome 3 locus (rs10510751, unknown function, G/T, CCR2; CCR3, physical position 46321029)       
    Age- and sex-adjusted       
        β Estimate, SE 0.11, 0.013 0.12, 0.024 −0.11, 0.012 0.06, 0.023 0.10, 0.022 0.08, 0.016 
        P 8.9 * 10−16 6.1 * 10−7 1.2 * 10−20 .011 5.7 * 10−6 3.7 * 10−7 
        MAF, % 8.7 8.3 8.6 7.8 8.3 8.1 
    Multivariable-adjusted       
        β Estimate, SE 0.11, 0.013 0.12, 0.024 0.11, 0.012 0.06, 0.023 0.10, 0.022 0.08, 0.016 
        P 1.7 * 10−16 6.1 * 10−7 1.9 * 10−21 .01 4.5 * 10−6 4.0 * 10−7 
Chromosome 2 locus (rs7601375, T/C, intronic, COBLL1, physical position 46317506)       
    Age- and sex-adjusted       
        β Estimate, SE −0.01, 0.006 −0.006, 0.013 −0.01, 0.006 −0.04, 0.012 −0.04, 0.012 −0.04, 0.009 
        P .07 .65 .07 .0007 .0004 7.8 * 10−7 
        MAF, % 40.8 40.0 40.1 39.7 40.0 39.9 
    Multivariable-adjusted       
        β Estimate, SE −0.01, 0.006 −0.006, 0.013 −0.01, 0.006 −0.04, 0.012 −0.04, 0.012 −0.04, 0.009 
        P .07 .65 .07 .0004 .0006 9.6 * 10−7 

Data are provided for the strongest associations for the respective locus for SNPs available in both studies (genotyped or imputed).

dbSNP positions are from NCBI Build 36. For comparison the respective results for multivariable-adjusted associations (secondary analysis) are provided. The β values are for log-transformed MCP-1 residuals.

Plasma MCP-1 concentrations were not available in FHS, serum concentrations were not available in ARIC.

LD r2 rs12495098 and rs10510751 are 1.0.

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