Association of clinical and genetic features in CRLF2-rearranged cases in high-risk B-progenitor ALL
| Characteristic . | Disrupted CRLF2 . | Intact CRLF2 . | Total* . | P† . |
|---|---|---|---|---|
| No. of patients | 29 | 178 | 207 | |
| Age | ||||
| 10 y or older | 21 | 111 | 132 | .405 |
| Younger than 10 y | 8 | 67 | 75 | |
| Median age, y | 14.2 | 12.8 | 13.1 | > .030¶ |
| DS cases‡ | ||||
| DS | 2 | 6 | 8 | > .314 |
| Not DS | 21 | 134 | 155 | |
| Sex | ||||
| Male | 21 | 116 | 137 | .529 |
| Female | 8 | 62 | 70 | |
| WBC, ×1000/μL | ||||
| 50 or more | 16 | 92 | 108 | < .842 |
| Less than 50 | 13 | 86 | 99 | |
| Median WBC | 92.7 | 59.6 | 62.3 | < .198¶ |
| Ethnicity§ | ||||
| Hispanic/Latino | 18 | 33 | 51 | < .001 |
| Other | 11 | 143 | 154 | |
| BCR-ABL1–like GEP | ||||
| Yes | 18 | 20 | 38 | < .001 |
| No | 11 | 158 | 169 | |
| IKZF1 alteration‖ | ||||
| Deletion/mutation | 21 | 35 | 56 | < .001 |
| Normal | 5 | 126 | 131 | |
| JAK mutations‖ | ||||
| Mutation | 18 | 2 | 20 | < .001 |
| Normal | 8 | 159 | 167 | |
| CNS blasts | ||||
| No blasts | 19 | 141 | 160 | < .196 |
| Less than 5 | 6 | 20 | 26 | |
| 5 or more | 4 | 17 | 21 | |
| Probability of 4-year RFS | 35.3 (9.5) | 71.3 (3.6) | 66.3 (3.5) | .001# |
| Characteristic . | Disrupted CRLF2 . | Intact CRLF2 . | Total* . | P† . |
|---|---|---|---|---|
| No. of patients | 29 | 178 | 207 | |
| Age | ||||
| 10 y or older | 21 | 111 | 132 | .405 |
| Younger than 10 y | 8 | 67 | 75 | |
| Median age, y | 14.2 | 12.8 | 13.1 | > .030¶ |
| DS cases‡ | ||||
| DS | 2 | 6 | 8 | > .314 |
| Not DS | 21 | 134 | 155 | |
| Sex | ||||
| Male | 21 | 116 | 137 | .529 |
| Female | 8 | 62 | 70 | |
| WBC, ×1000/μL | ||||
| 50 or more | 16 | 92 | 108 | < .842 |
| Less than 50 | 13 | 86 | 99 | |
| Median WBC | 92.7 | 59.6 | 62.3 | < .198¶ |
| Ethnicity§ | ||||
| Hispanic/Latino | 18 | 33 | 51 | < .001 |
| Other | 11 | 143 | 154 | |
| BCR-ABL1–like GEP | ||||
| Yes | 18 | 20 | 38 | < .001 |
| No | 11 | 158 | 169 | |
| IKZF1 alteration‖ | ||||
| Deletion/mutation | 21 | 35 | 56 | < .001 |
| Normal | 5 | 126 | 131 | |
| JAK mutations‖ | ||||
| Mutation | 18 | 2 | 20 | < .001 |
| Normal | 8 | 159 | 167 | |
| CNS blasts | ||||
| No blasts | 19 | 141 | 160 | < .196 |
| Less than 5 | 6 | 20 | 26 | |
| 5 or more | 4 | 17 | 21 | |
| Probability of 4-year RFS | 35.3 (9.5) | 71.3 (3.6) | 66.3 (3.5) | .001# |
ALL indicates acute lymphoblastic leukemia; DS, Down syndrome; WBC, white blood cell count; GEP, gene expression profiling; CNS, central nervous system; and RFS, relapse-free survival.
All 207 patients were used unless otherwise noted.
P values were calculated using Fisher exact test unless otherwise noted.
DS status was available for 163 patients.
Ethnicity information was available for 205 patients.
Sequence information was available for 187 patients.
Mann-Whitney test was used to calculate WBC and age continuous variables.
Log-rank test used to calculate survival P value.