Factors associated with 2-year TRM: multivariate analysis
| Factor . | Relative risk of TRM (95% CI) . | P . | Overall P . |
|---|---|---|---|
| Day 28 response | < .001 | ||
| CR* | 1.0 | ||
| VGPR | 0.61 (0.34-1.10) | .10 | |
| PR | 1.21 (0.71-2.06) | .48 | |
| VGPR + PR | 0.82 (0.54-1.25) | .36 | |
| NR | 2.78 (2.17-3.56) | < .001 | |
| Initial acute GVHD grade | .05 | ||
| I* | 1.0 | ||
| II | 1.13 (0.83-1.54) | .42 | |
| III-IV | 1.63 (1.00-2.66) | .05 | |
| Organ involvement | .04 | ||
| Other organs* | 1.0 | ||
| Skin only | 1.38 (1.01-1.89) | ||
| Age | < .01 | ||
| Younger than 10 y* | 1.0 | ||
| 10-17 y | 1.65 (1.09-2.66) | .02 | |
| 18-35 y | 1.69 (1.13-2.54) | .01 | |
| 36 y or older | 1.94 (1.31-2.89) | .01 | |
| Disease risk | .01 | ||
| Standard* | 1.0 | ||
| High | 1.36 (1.07-1.73) | .01 | |
| Donor type | < .01 | ||
| Matched sibling* | 1.0 | ||
| URD well-matched | 1.42 (0.92-2.20) | .11 | |
| URD partially matched | 1.61 (1.09-2.38) | .02 | |
| URD- or sibling-mismatched | 1.88 (1.34-2.63) | < .001 | |
| Single UCB | 1.18 (0.72-1.94) | .52 | |
| Double UCB | 0.73 (0.44-1.20) | .21 |
| Factor . | Relative risk of TRM (95% CI) . | P . | Overall P . |
|---|---|---|---|
| Day 28 response | < .001 | ||
| CR* | 1.0 | ||
| VGPR | 0.61 (0.34-1.10) | .10 | |
| PR | 1.21 (0.71-2.06) | .48 | |
| VGPR + PR | 0.82 (0.54-1.25) | .36 | |
| NR | 2.78 (2.17-3.56) | < .001 | |
| Initial acute GVHD grade | .05 | ||
| I* | 1.0 | ||
| II | 1.13 (0.83-1.54) | .42 | |
| III-IV | 1.63 (1.00-2.66) | .05 | |
| Organ involvement | .04 | ||
| Other organs* | 1.0 | ||
| Skin only | 1.38 (1.01-1.89) | ||
| Age | < .01 | ||
| Younger than 10 y* | 1.0 | ||
| 10-17 y | 1.65 (1.09-2.66) | .02 | |
| 18-35 y | 1.69 (1.13-2.54) | .01 | |
| 36 y or older | 1.94 (1.31-2.89) | .01 | |
| Disease risk | .01 | ||
| Standard* | 1.0 | ||
| High | 1.36 (1.07-1.73) | .01 | |
| Donor type | < .01 | ||
| Matched sibling* | 1.0 | ||
| URD well-matched | 1.42 (0.92-2.20) | .11 | |
| URD partially matched | 1.61 (1.09-2.38) | .02 | |
| URD- or sibling-mismatched | 1.88 (1.34-2.63) | < .001 | |
| Single UCB | 1.18 (0.72-1.94) | .52 | |
| Double UCB | 0.73 (0.44-1.20) | .21 |
Reference group.