Table 2 Comparative analysis of... | American Society of Hematology

Table 2

Comparative analysis of cytokines released by LPS-activated TGF-GM-DCs and TGF-M-DCs

	Cytokines, pg/mL
	CM: mature (LPS-stimulated) TGF-GM-DCs	CM: mature (LPS-stimulated) TGF-M-DCs
Significant decrease of TGF-M-DCs to TGF-GM-DCs
IL-1β	86 ± 4	3 ± 3*
IL-6	50305 ± 1282	20661 ± 2251†
GM-CSF	559 ± 67	40 ± 14*
VEGF	103 ± 4	15 ± 15†
Significant increase when comparing TGF-M-DCs to TGF-GM-DCs: IL-10	195 ± 115	829 ± 251*
No significant change from TGF-GM-DCs to TGF-M-DCs
TGF-β	41 ± 13	27 ± 3
M-CSF	13 ± 13	34 ± 34
PDGF-BB	242 ± 101	151 ± 151
IL-2	12 ± 1	22 ± 13
IL-3	ND	ND
IL-12	40 ± 40	ND
IL-17	ND	ND

	Cytokines, pg/mL
	CM: mature (LPS-stimulated) TGF-GM-DCs	CM: mature (LPS-stimulated) TGF-M-DCs
Significant decrease of TGF-M-DCs to TGF-GM-DCs
IL-1β	86 ± 4	3 ± 3*
IL-6	50305 ± 1282	20661 ± 2251†
GM-CSF	559 ± 67	40 ± 14*
VEGF	103 ± 4	15 ± 15†
Significant increase when comparing TGF-M-DCs to TGF-GM-DCs: IL-10	195 ± 115	829 ± 251*
No significant change from TGF-GM-DCs to TGF-M-DCs
TGF-β	41 ± 13	27 ± 3
M-CSF	13 ± 13	34 ± 34
PDGF-BB	242 ± 101	151 ± 151
IL-2	12 ± 1	22 ± 13
IL-3	ND	ND
IL-12	40 ± 40	ND
IL-17	ND	ND

Conditioned medium prepared from 5 × 10⁵ cells/mL. Data represent average cytokine levels of triplicate ± SEM from 4 different donors.

ND indicates nondetectable in all 4 donor samples.

P < .05 when using 2-tailed t test.

P < .05 when using 1-tailed t test.