Summary of blood analyses of control and JAK2V617F transgenic mice*
| . | WBC, ×109/L . | RBC, ×1012/L . | HGB, g/L . | HCT, % . | PLT, ×109/L . | MCV, fm3 . | MCH, pg . | MCHC, g/L . |
|---|---|---|---|---|---|---|---|---|
| Nontransgenic control, n = 30 | ||||||||
| Mean | 8.29 | 9.61 | 15.2 | 45.4 | 968 | 46.9 | 15.6 | 34.8 |
| SD | 2.54 | 0.55 | 0.76 | 1.78 | 89 | 1.4 | 0.60 | 1.45 |
| Range | 5.0-10.9 | 8.2-10.9 | 14-17.2 | 40.2-49.8 | 765-1254 | 45-50 | 14.9-17.1 | 33.6-39.3 |
| Transgenic line A, n = 38 | ||||||||
| Mean | 11.8 | 12.9 | 18.1 | 50.9 | 2708 | 43.1 | 14.4 | 34.1 |
| SD | 2.85 | 1.05 | 1.40 | 4.42 | 712 | 2.09 | 0.59 | 1.2 |
| Range | 6.2-17.7 | 9.50-16.7 | 15-21.9 | 42.7-65.4 | 1226-5621 | 38-48 | 13.5-15.9 | 32.2-37.5 |
| P value | < .05 | < .05 | < .05 | < .05 | < .05 | < .05 | < .05 | > .05 |
| Transgenic line B, n = 34 | ||||||||
| Mean | 9.14 | 11.7 | 16.5 | 48.0 | 1278 | 45.1 | 15.1 | 34.3 |
| SD | 2.63 | 0.64 | 0.59 | 2.87 | 215 | 1.58 | 0.59 | 1.2 |
| Range | 4.9-19.0 | 9.60-12.5 | 14.7-17.8 | 42.0-54.1 | 904-2021 | 42-48 | 13.5-16.2 | 32-37 |
| P value | > .05 | < .05 | < .05 | < .05 | < .05 | < .05 | < .05 | > .05 |
| . | WBC, ×109/L . | RBC, ×1012/L . | HGB, g/L . | HCT, % . | PLT, ×109/L . | MCV, fm3 . | MCH, pg . | MCHC, g/L . |
|---|---|---|---|---|---|---|---|---|
| Nontransgenic control, n = 30 | ||||||||
| Mean | 8.29 | 9.61 | 15.2 | 45.4 | 968 | 46.9 | 15.6 | 34.8 |
| SD | 2.54 | 0.55 | 0.76 | 1.78 | 89 | 1.4 | 0.60 | 1.45 |
| Range | 5.0-10.9 | 8.2-10.9 | 14-17.2 | 40.2-49.8 | 765-1254 | 45-50 | 14.9-17.1 | 33.6-39.3 |
| Transgenic line A, n = 38 | ||||||||
| Mean | 11.8 | 12.9 | 18.1 | 50.9 | 2708 | 43.1 | 14.4 | 34.1 |
| SD | 2.85 | 1.05 | 1.40 | 4.42 | 712 | 2.09 | 0.59 | 1.2 |
| Range | 6.2-17.7 | 9.50-16.7 | 15-21.9 | 42.7-65.4 | 1226-5621 | 38-48 | 13.5-15.9 | 32.2-37.5 |
| P value | < .05 | < .05 | < .05 | < .05 | < .05 | < .05 | < .05 | > .05 |
| Transgenic line B, n = 34 | ||||||||
| Mean | 9.14 | 11.7 | 16.5 | 48.0 | 1278 | 45.1 | 15.1 | 34.3 |
| SD | 2.63 | 0.64 | 0.59 | 2.87 | 215 | 1.58 | 0.59 | 1.2 |
| Range | 4.9-19.0 | 9.60-12.5 | 14.7-17.8 | 42.0-54.1 | 904-2021 | 42-48 | 13.5-16.2 | 32-37 |
| P value | > .05 | < .05 | < .05 | < .05 | < .05 | < .05 | < .05 | > .05 |
WBC indicates white blood cells; RBC, red blood cells; HGB, hemoglobin; HCT, hematocrit; PLT, platelet; MCV, mean corpuscular volume; MCH, mean corpuscular hemoglobin; and MCHC, mean corpuscular hemoglobin concentration.
Complete blood count analyses were performed with 10- to 12-week-old transgenic mice (F2 to F6 generations, about equal numbers of male and female) and their nontransgenic siblings. P values were calculated in reference to the nontransgenic control.