Risk factors associated with increased risk of therapy-related myelodysplasia and acute myeloid leukemia: proportion-hazard regression analysis
| Characteristic . | Relative risk (95% confidence interval) . | |||
|---|---|---|---|---|
| All t-MDS/AML . | 11q23 . | Deletion of chromosome 5/7 . | Unknown cytogenetics . | |
| Age at diagnosis, y | ||||
| 0 to 9 | Reference | NE* | Reference | Reference |
| 10 to 17 | 0.46 (0.12-1.72) | NE* | 0.48 (0.18-1.31) | 1.27 (0.11-14.08) |
| 18 or older | 1.09 (0.20-5.84) | NE* | 0.81 (0.23-2.87) | 3.33 (0.20-54.7) |
| Sex | ||||
| Male | Reference | Reference | Reference | Reference |
| Female | 1.69 (0.51-5.59) | 0.56 (0.16-1.92) | 1.08 (0.43-2.70) | 3.87 (0.40-37.66) |
| Treatment group | ||||
| Standard | Reference | Reference | NE† | Reference |
| Experimental | 0.62 (0.10-3.71) | 0.80 (0.19-3.32) | NE† | 0.51 (0.05-5.63) |
| Regimen C | 15.91 (3.84-65.82) | 7.26 (1.72-30.59) | NE† | 4.42 (0.38-51.47) |
| Local control‡ | ||||
| Surgery only/no treatment | Reference | NE§ | NE‖ | Reference |
| Surgery and radiation | 1.97 (0.27-14.32) | NE§ | NE‖ | 3.73 (0.32-42.85) |
| Characteristic . | Relative risk (95% confidence interval) . | |||
|---|---|---|---|---|
| All t-MDS/AML . | 11q23 . | Deletion of chromosome 5/7 . | Unknown cytogenetics . | |
| Age at diagnosis, y | ||||
| 0 to 9 | Reference | NE* | Reference | Reference |
| 10 to 17 | 0.46 (0.12-1.72) | NE* | 0.48 (0.18-1.31) | 1.27 (0.11-14.08) |
| 18 or older | 1.09 (0.20-5.84) | NE* | 0.81 (0.23-2.87) | 3.33 (0.20-54.7) |
| Sex | ||||
| Male | Reference | Reference | Reference | Reference |
| Female | 1.69 (0.51-5.59) | 0.56 (0.16-1.92) | 1.08 (0.43-2.70) | 3.87 (0.40-37.66) |
| Treatment group | ||||
| Standard | Reference | Reference | NE† | Reference |
| Experimental | 0.62 (0.10-3.71) | 0.80 (0.19-3.32) | NE† | 0.51 (0.05-5.63) |
| Regimen C | 15.91 (3.84-65.82) | 7.26 (1.72-30.59) | NE† | 4.42 (0.38-51.47) |
| Local control‡ | ||||
| Surgery only/no treatment | Reference | NE§ | NE‖ | Reference |
| Surgery and radiation | 1.97 (0.27-14.32) | NE§ | NE‖ | 3.73 (0.32-42.85) |
NE indicates not estimated.
All 3 patients with 11q23 abnormalities were less than 9 years at diagnosis, so that risk could not be estimated.
All 5 patients with deletion of chromosome 5 or 7 were in regimen C so that risk could not be estimated.
Only 371 patients had nonmetastatic tumor and enough local control.
Only 1 patient of the 371 patients had 11q23 abnormality so that relative risk could not be estimated.
None of the 371 patients had deletion of chromosomes 5 or 7, so that relative risk could not be estimated.