Characteristics of the patients included in the study
| Pt . | Age at diagnosis, y . | Sex, M/F . | WBC at diagnosis × 109/L . | Eos at diagnosis × 109/L . | Plts at diagnosis × 109/L . | Duration of disease, mo . | Prior therapy . | Cytogenetics . | Fusion gene . |
|---|---|---|---|---|---|---|---|---|---|
| 1 | 50 | M | 52 | 4.8 | 190 | 15 | None | t(5;12) (q33;p13) | ETV6-PDGFRB |
| 2 | 69 | M | 41 | 1.6 | 192 | 18 | None | t(5;12) (q33;p13) | ETV6-PDGFRB |
| 3 | 32 | M | 80 | 7.8 | 74 | 54 | HU,IFN | t(5;12) (q33;p13) | ETV6-PDGFRB |
| 4 | 51 | M | 20.6 | 1.8 | 245 | 9 | HU, IFN | t(5;12) (q33;p13) | ETV6-PDGFRB |
| 5 | 56 | M | 80 | 3.2 | 91 | 9 | None | t(5;12) (q33;p13) | ETV6-PDGFRB |
| 6 | 36 | M | 56.9 | 5.0 | 114 | 1 | None | t(5;12) (q33;p13) | ETV6-PDGFRB |
| 7 | 57 | F | 66 | 5.0 | 113 | 2 | HU | t(5,12) | ETV6-PDGFRB |
| 8 | 48 | M | 10.8 | 8.4 | 131 | 16 | HU | ins t(2;12) (p21;q?13q?22), del(5)(q33q35) | ETV6-PDGFRB |
| 9 | 6 | M | 9.3 | 4.1 | 506 | 174 | HU, IFN, steroid | t(5;12) (q33;q13) | PDGFRB Partner unknown |
| 10 | 68 | M | 46.5 | 12.6 | 198 | 25 | HU, IFN | t(3;5) (p21,q31) | PDGFRB Partner unknown |
| 11 | 78 | M | 138 | 5.4 | 92 | 17 | HU, IFN, Bu, 6-MP | t(5;15) (q33,q22) | TP53BP1-PDGFRB |
| 12 | 65 | F | 62 | 3.5 | 124 | 82 | HU, Bu, FLAG-Ida | t(1;3;5) (p36;p21;q33) | PDGFRB Partner unknown |
| Pt . | Age at diagnosis, y . | Sex, M/F . | WBC at diagnosis × 109/L . | Eos at diagnosis × 109/L . | Plts at diagnosis × 109/L . | Duration of disease, mo . | Prior therapy . | Cytogenetics . | Fusion gene . |
|---|---|---|---|---|---|---|---|---|---|
| 1 | 50 | M | 52 | 4.8 | 190 | 15 | None | t(5;12) (q33;p13) | ETV6-PDGFRB |
| 2 | 69 | M | 41 | 1.6 | 192 | 18 | None | t(5;12) (q33;p13) | ETV6-PDGFRB |
| 3 | 32 | M | 80 | 7.8 | 74 | 54 | HU,IFN | t(5;12) (q33;p13) | ETV6-PDGFRB |
| 4 | 51 | M | 20.6 | 1.8 | 245 | 9 | HU, IFN | t(5;12) (q33;p13) | ETV6-PDGFRB |
| 5 | 56 | M | 80 | 3.2 | 91 | 9 | None | t(5;12) (q33;p13) | ETV6-PDGFRB |
| 6 | 36 | M | 56.9 | 5.0 | 114 | 1 | None | t(5;12) (q33;p13) | ETV6-PDGFRB |
| 7 | 57 | F | 66 | 5.0 | 113 | 2 | HU | t(5,12) | ETV6-PDGFRB |
| 8 | 48 | M | 10.8 | 8.4 | 131 | 16 | HU | ins t(2;12) (p21;q?13q?22), del(5)(q33q35) | ETV6-PDGFRB |
| 9 | 6 | M | 9.3 | 4.1 | 506 | 174 | HU, IFN, steroid | t(5;12) (q33;q13) | PDGFRB Partner unknown |
| 10 | 68 | M | 46.5 | 12.6 | 198 | 25 | HU, IFN | t(3;5) (p21,q31) | PDGFRB Partner unknown |
| 11 | 78 | M | 138 | 5.4 | 92 | 17 | HU, IFN, Bu, 6-MP | t(5;15) (q33,q22) | TP53BP1-PDGFRB |
| 12 | 65 | F | 62 | 3.5 | 124 | 82 | HU, Bu, FLAG-Ida | t(1;3;5) (p36;p21;q33) | PDGFRB Partner unknown |
Pt indicates patient; M, male; F, female; WBC, white blood cell count; Eos, eosinophil cell count; Plts, platelet count; HU, hydroxyurea; IFN, interferon-alpha; Bu, busulphan; and 6-MP, 6-mercaptopurine.