Hematology and histology of p110γKOδD910A mice
| Phenotype/parameter . | Frequency . | Individual mouse . | |||
|---|---|---|---|---|---|
| F1 . | F2 . | M1 . | M2 . | ||
| Hematology | |||||
| Neutrophilia | 4/4 | +++ | +++ | ++ | +++ |
| Eosinophilia | 4/4 | +++ | ++ | +++ | +++ |
| Lymphocytopenia | 4/4 | +++ | +++ | +++ | +++ |
| Thrombocytosis | 4/4 | + | + | + | + |
| Erythrocytosis | 2/4 | + | – | – | + |
| Erythrocytopenia | 1/4 | – | – | + | – |
| Histology | |||||
| Lymphoid organs | |||||
| Thymus, diffuse lymphoid atrophy | 4/4 | +++ | ++ | +++ | ++ |
| Spleen, diffuse lymphoid depletion | 4/4 | +++ | +++ | +++ | +++ |
| Spleen, extramedullary hematopoiesis | 4/4 | + | +++ | + | ++ |
| Bone marrow, granulocytic hyperplasia | 4/4 | + | + | + | + |
| Small intestines, Peyer patches | 2/4 | Absent | Remnants | Remnants | Absent |
| Large intestines, Peyer patches | 4/4 | Remnants | Remnants | Remnants | Remnants |
| Inflammation | |||||
| Gastritis, acute and diffuse | 4/4 | ++ | ++ | ++ | ++ |
| Sialoadenitis submandibular, acute & focally extensive | 3/4 | + | – | +++ | +++ |
| Sialoadenitis, parotid, acute & focally extensive | 2/4 | – | +++ | – | +++ |
| Enteritis, acute & diffuse | 1/4 | – | – | –/+ | – |
| Laryngitis, acute | 1/4 | – | + | – | – |
| Glossitis, acute | 2/4 | – | + | – | –/+ |
| Blepharitis, acute | 1/4 | – | – | –/+ | – |
| Rhinitis | 1/4 | – | – | –/+ | – |
| Cholecystis | 1/4 | – | – | – | –/+ |
| Esophagitis | 1/4 | – | – | – | –/+ |
| Lymphadenitis (submandibular), acute | 1/4 | – | – | – | +++ |
| Epididymitis, chronic & active | 1/4 | – | – | – | +++ |
| Posthitis, acute | 1/4 | – | – | – | + |
| Phenotype/parameter . | Frequency . | Individual mouse . | |||
|---|---|---|---|---|---|
| F1 . | F2 . | M1 . | M2 . | ||
| Hematology | |||||
| Neutrophilia | 4/4 | +++ | +++ | ++ | +++ |
| Eosinophilia | 4/4 | +++ | ++ | +++ | +++ |
| Lymphocytopenia | 4/4 | +++ | +++ | +++ | +++ |
| Thrombocytosis | 4/4 | + | + | + | + |
| Erythrocytosis | 2/4 | + | – | – | + |
| Erythrocytopenia | 1/4 | – | – | + | – |
| Histology | |||||
| Lymphoid organs | |||||
| Thymus, diffuse lymphoid atrophy | 4/4 | +++ | ++ | +++ | ++ |
| Spleen, diffuse lymphoid depletion | 4/4 | +++ | +++ | +++ | +++ |
| Spleen, extramedullary hematopoiesis | 4/4 | + | +++ | + | ++ |
| Bone marrow, granulocytic hyperplasia | 4/4 | + | + | + | + |
| Small intestines, Peyer patches | 2/4 | Absent | Remnants | Remnants | Absent |
| Large intestines, Peyer patches | 4/4 | Remnants | Remnants | Remnants | Remnants |
| Inflammation | |||||
| Gastritis, acute and diffuse | 4/4 | ++ | ++ | ++ | ++ |
| Sialoadenitis submandibular, acute & focally extensive | 3/4 | + | – | +++ | +++ |
| Sialoadenitis, parotid, acute & focally extensive | 2/4 | – | +++ | – | +++ |
| Enteritis, acute & diffuse | 1/4 | – | – | –/+ | – |
| Laryngitis, acute | 1/4 | – | + | – | – |
| Glossitis, acute | 2/4 | – | + | – | –/+ |
| Blepharitis, acute | 1/4 | – | – | –/+ | – |
| Rhinitis | 1/4 | – | – | –/+ | – |
| Cholecystis | 1/4 | – | – | – | –/+ |
| Esophagitis | 1/4 | – | – | – | –/+ |
| Lymphadenitis (submandibular), acute | 1/4 | – | – | – | +++ |
| Epididymitis, chronic & active | 1/4 | – | – | – | +++ |
| Posthitis, acute | 1/4 | – | – | – | + |
+++ indicates marked; ++, moderate; +, mild; –, normal; and +/–, minimal.