Table 2 The HLA-G–related regulatory... | American Society of Hematology

Table 2

The HLA-G–related regulatory cells

Name	Generation	Phenotype	HLA-G induction	HLA-G expression	Mechanism of action	Reference
Regulatory T cells
HLA-G–induced Treg	Periphery	None known/CD3⁺CD4^low and CD3⁺CD8^low	APC-HLA-G1⁺ or HLA-G5	No	Unknown/soluble factors including IL-10	82/55, 57
HLA-G⁺ Tregs	Thymus	CD3⁺HLA-G1⁺	No	HLA-G1 and HLA-G5	Soluble factors including HLA-G	83
HLA-G1^acq+ T cells	Periphery	CD3⁺HLA-G1⁺	Trogocytic HLA-G1 acquisition	HLA-G1	HLA-G1	38
CD4⁺CD25⁺CTLA4⁺/CD8⁺CD28⁻	Periphery	CD4⁺CD25⁺/CD8⁺CD28-	HLA-G–modified DC	No	—/possibly IL-10	40
Tolerogenic APC
HLA-G1⁺ APC	Periphery	HLA-G1⁺	No	HLA-G1	HLA-G1	82
HLA-G–modified DC	Periphery	HLA-DR^low, CD80^low, CD86^low	HLA-G tetramers	No	—	40
Suppressive NK cells: HLA-G^acq+ NK cells	Periphery	CD16⁺HLA-G1⁺	Trogocytic HLA-G1 acquisition	HLA-G1	HLA-G1	39

Name	Generation	Phenotype	HLA-G induction	HLA-G expression	Mechanism of action	Reference
Regulatory T cells
HLA-G–induced Treg	Periphery	None known/CD3⁺CD4^low and CD3⁺CD8^low	APC-HLA-G1⁺ or HLA-G5	No	Unknown/soluble factors including IL-10	82/55, 57
HLA-G⁺ Tregs	Thymus	CD3⁺HLA-G1⁺	No	HLA-G1 and HLA-G5	Soluble factors including HLA-G	83
HLA-G1^acq+ T cells	Periphery	CD3⁺HLA-G1⁺	Trogocytic HLA-G1 acquisition	HLA-G1	HLA-G1	38
CD4⁺CD25⁺CTLA4⁺/CD8⁺CD28⁻	Periphery	CD4⁺CD25⁺/CD8⁺CD28-	HLA-G–modified DC	No	—/possibly IL-10	40
Tolerogenic APC
HLA-G1⁺ APC	Periphery	HLA-G1⁺	No	HLA-G1	HLA-G1	82
HLA-G–modified DC	Periphery	HLA-DR^low, CD80^low, CD86^low	HLA-G tetramers	No	—	40
Suppressive NK cells: HLA-G^acq+ NK cells	Periphery	CD16⁺HLA-G1⁺	Trogocytic HLA-G1 acquisition	HLA-G1	HLA-G1	39

— indicates not applicable.