Table 1 Comparison of viral RNA copies... | American Society of Hematology

Table 1

Comparison of viral RNA copies in plasma and HIV-DNA copies in the spleen, BM, and thymus from hNOG mice receiving low- and high-dose viral inoculations

Mouse ID no.	HIV strain	TCID₅₀	Time after inoculation, d	RNA viral copies/mL	CD4/CD8 ratio	HIV-DNA copies/10⁶ human cells
Mouse ID no.	HIV strain	TCID₅₀	Time after inoculation, d	RNA viral copies/mL	CD4/CD8 ratio	Splee	BM	Thymus
Low-dose viral inoculation group
113-1	HIV-1_JRCSF	200	18	6 240	1.8	34 177	11 785	3 495
112-2	HIV-1_JRCSF	200	18	<500	1.2	< 100	< 100	< 100
113-2	HIV-1_JRCSF	200	40	6 177	1.6	25 855	27 920	3 473
112-3	HIV-1_JRCSF	200	40	<500	0.9	< 100	< 100	<100
112-4	HIV-1_MNp	180	18	72 477	1.3	18 873	100	ND
113-4	HIV-1_MNp	180	40	70 667	0.3	4 947	653	32 163
112-1	HIV-1_MNp	180	40	<500	0.9	< 100	< 100	< 100
High-dose viral inoculation group
136-3	HIV-1_JRCSF	65 000	25	252 381	0.8	958 871	1 797 600	232 155
136-2	HIV-1_JRCSF	65 000	29	50 167	0.7	41 172	54 521	8 600
141-1	HIV-1_JRCSF	65 000	30	67 667	2.2	27 735	52 430	429
161-3	HIV-1_JRCSF	65 000	30	13 847	0.9	104 466	14 653	111 080
157-3	HIV-1_MNp	20 000	31	1 253 925	0.5	41 053	56 802	976 556
157-4	HIV-1_MNp	20 000	31	147 973	0.6	3 634	262	40 796
161-6	HIV-1_MNp	20 000	31	108 073	1.7	4 991	< 100	3 673

Mouse ID no.	HIV strain	TCID₅₀	Time after inoculation, d	RNA viral copies/mL	CD4/CD8 ratio	HIV-DNA copies/10⁶ human cells
Mouse ID no.	HIV strain	TCID₅₀	Time after inoculation, d	RNA viral copies/mL	CD4/CD8 ratio	Splee	BM	Thymus
Low-dose viral inoculation group
113-1	HIV-1_JRCSF	200	18	6 240	1.8	34 177	11 785	3 495
112-2	HIV-1_JRCSF	200	18	<500	1.2	< 100	< 100	< 100
113-2	HIV-1_JRCSF	200	40	6 177	1.6	25 855	27 920	3 473
112-3	HIV-1_JRCSF	200	40	<500	0.9	< 100	< 100	<100
112-4	HIV-1_MNp	180	18	72 477	1.3	18 873	100	ND
113-4	HIV-1_MNp	180	40	70 667	0.3	4 947	653	32 163
112-1	HIV-1_MNp	180	40	<500	0.9	< 100	< 100	< 100
High-dose viral inoculation group
136-3	HIV-1_JRCSF	65 000	25	252 381	0.8	958 871	1 797 600	232 155
136-2	HIV-1_JRCSF	65 000	29	50 167	0.7	41 172	54 521	8 600
141-1	HIV-1_JRCSF	65 000	30	67 667	2.2	27 735	52 430	429
161-3	HIV-1_JRCSF	65 000	30	13 847	0.9	104 466	14 653	111 080
157-3	HIV-1_MNp	20 000	31	1 253 925	0.5	41 053	56 802	976 556
157-4	HIV-1_MNp	20 000	31	147 973	0.6	3 634	262	40 796
161-6	HIV-1_MNp	20 000	31	108 073	1.7	4 991	< 100	3 673

Seven mice inoculated with a low infectious dose of HIV-1_JRCSF (200 TCID₅₀) or HIV-1_MNp (180 TCID₅₀), and 7 mice receiving a high infectious dose of HIV-1_JRCSF (65 000 TCID₅₀) or HIV-1_MNp (20 000 TCID₅₀) were listed.

ND indicates not done.

View Large

This Feature Is Available To Subscribers Only