Characteristics associated with the JAK2V617F mutation in 137 patients with portal vein thrombosis
| PVT patients . | Without JAK2V617F, n = 90 (median [Q1-Q3]) . | With JAK2 V617F, n = 47 (median [Q1-Q3]) . | P . |
|---|---|---|---|
| Age, y | 49 [37-62] | 53 [36-60] | .96 |
| Males, % | 52 (57.8%) | 25 (53.2%) | .72 |
| Hemoglobin, g/dL | 13 [10.8-14.5] | 12.9 [12.1-14.5] | .73 |
| Hematocrit, % | 38.2 [33-43] | 40 [37-45] | .06 |
| MCV, fL | 87.1 [82.2-91] | 86.2 [82.2-90] | .64 |
| WBC count, ×109/L | 5.35 [3.9-7.1] | 6.8 [4.9-9.6] | .005 |
| ANC, ×109/L | 3.48 [2.5-4.6] | 4.76 [3.4-6.5] | .016 |
| Platelet count, ×109/L | 141 [101-230] | 323 [214-437] | <.001 |
| Spleen size BCM, cm | 0 [0-3] | 8 [4-15] | <.001 |
| Serum EPO, mU/mL | 14 [8.2-27] | 10.5 [6.8-14.7] | .027 |
| Measured RCM, mL/kg | 26.9 [24-31.7] | 34.5 [30-38] | <.001 |
| Predicted RCM, mL/kg | 25 [23.2-26] | 26.4 [24-27.5] | .075 |
| RCM more than 125% of predicted | 11/41 (26.8%) | 20/32 (62.5%) | .004 |
| AST, ULN | 28 [19.5-40] | 30 [22.5-42.5] | .41 |
| ALT, ULN | 35 [20-52.5] | 34 [25-62.5] | .68 |
| Serum bilirubin, μmol/L | 15.4 [12.5-25.8] | 16 [13-25] | .71 |
| Serum creatinine, μmol/L | 74 [61.9-88] | 75 [66.5-79.8] | .84 |
| Serum albumin, g/dL | 38.5 [35.2-42.7] | 40 [38-45] | .054 |
| Factor V, % | 92 [63.2-109.5] | 63.5 [47.7-86] | .004 |
| PVT patients . | Without JAK2V617F, n = 90 (median [Q1-Q3]) . | With JAK2 V617F, n = 47 (median [Q1-Q3]) . | P . |
|---|---|---|---|
| Age, y | 49 [37-62] | 53 [36-60] | .96 |
| Males, % | 52 (57.8%) | 25 (53.2%) | .72 |
| Hemoglobin, g/dL | 13 [10.8-14.5] | 12.9 [12.1-14.5] | .73 |
| Hematocrit, % | 38.2 [33-43] | 40 [37-45] | .06 |
| MCV, fL | 87.1 [82.2-91] | 86.2 [82.2-90] | .64 |
| WBC count, ×109/L | 5.35 [3.9-7.1] | 6.8 [4.9-9.6] | .005 |
| ANC, ×109/L | 3.48 [2.5-4.6] | 4.76 [3.4-6.5] | .016 |
| Platelet count, ×109/L | 141 [101-230] | 323 [214-437] | <.001 |
| Spleen size BCM, cm | 0 [0-3] | 8 [4-15] | <.001 |
| Serum EPO, mU/mL | 14 [8.2-27] | 10.5 [6.8-14.7] | .027 |
| Measured RCM, mL/kg | 26.9 [24-31.7] | 34.5 [30-38] | <.001 |
| Predicted RCM, mL/kg | 25 [23.2-26] | 26.4 [24-27.5] | .075 |
| RCM more than 125% of predicted | 11/41 (26.8%) | 20/32 (62.5%) | .004 |
| AST, ULN | 28 [19.5-40] | 30 [22.5-42.5] | .41 |
| ALT, ULN | 35 [20-52.5] | 34 [25-62.5] | .68 |
| Serum bilirubin, μmol/L | 15.4 [12.5-25.8] | 16 [13-25] | .71 |
| Serum creatinine, μmol/L | 74 [61.9-88] | 75 [66.5-79.8] | .84 |
| Serum albumin, g/dL | 38.5 [35.2-42.7] | 40 [38-45] | .054 |
| Factor V, % | 92 [63.2-109.5] | 63.5 [47.7-86] | .004 |
MCV indicates mean cell volume; WBC, white blood cell; ANC, absolute neutrophil count; BCM, below costal margin; and RCM, red cell mass.