Characteristics associated with the JAK2V617F mutation in 241 patients with Budd-Chiari syndrome or portal vein thrombosis
| All patients . | Without JAK2V617F, n = 147 (median [Q1-Q3]) . | With JAK2V617F, n = 94 (median [Q1-Q3]) . | P . |
|---|---|---|---|
| Age, y | 44 [35-59.7] | 47 [35.2-58] | .78 |
| Males, % | 76 (51.7%) | 36 (38.3%) | .048 |
| Hemoglobin, g/dL | 13 [11.3-14.4] | 13.75 [12.3-15.1] | .012 |
| Hematocrit, % | 39 [33.8-44] | 43 [38.7-47] | <.001 |
| MCV, fL | 87.3 [82.9-91.3] | 85 [81-88] | .023 |
| WBC count, ×109/L | 5.7 [4.3-7.6] | 8.52 [5.9-11.5] | <.001 |
| ANC, ×109/L | 3.67 [2.7-4.9] | 5.25 [3.7-9] | <.001 |
| Platelet count, ×109/L | 159 [104-257] | 333.5 [239-456] | <.001 |
| Spleen size BCM, cm | 0 [0-2.25] | 5 [0-11.25] | <.001 |
| Serum EPO, mU/mL | 16.2 [10.6-35] | 12 [7.4-17.] | .002 |
| Measured RCM, mL/kg | 26.2 [23-31] | 32.9 [27-37.1] | <.001 |
| Predicted RCM, (mL/kg | 24.7 [22-26.3] | 24.81 [23-27.4] | .37 |
| RCM more than 125% of predicted | 11/59 (18.6%) | 38/62 (61.3%) | <.001 |
| All patients . | Without JAK2V617F, n = 147 (median [Q1-Q3]) . | With JAK2V617F, n = 94 (median [Q1-Q3]) . | P . |
|---|---|---|---|
| Age, y | 44 [35-59.7] | 47 [35.2-58] | .78 |
| Males, % | 76 (51.7%) | 36 (38.3%) | .048 |
| Hemoglobin, g/dL | 13 [11.3-14.4] | 13.75 [12.3-15.1] | .012 |
| Hematocrit, % | 39 [33.8-44] | 43 [38.7-47] | <.001 |
| MCV, fL | 87.3 [82.9-91.3] | 85 [81-88] | .023 |
| WBC count, ×109/L | 5.7 [4.3-7.6] | 8.52 [5.9-11.5] | <.001 |
| ANC, ×109/L | 3.67 [2.7-4.9] | 5.25 [3.7-9] | <.001 |
| Platelet count, ×109/L | 159 [104-257] | 333.5 [239-456] | <.001 |
| Spleen size BCM, cm | 0 [0-2.25] | 5 [0-11.25] | <.001 |
| Serum EPO, mU/mL | 16.2 [10.6-35] | 12 [7.4-17.] | .002 |
| Measured RCM, mL/kg | 26.2 [23-31] | 32.9 [27-37.1] | <.001 |
| Predicted RCM, (mL/kg | 24.7 [22-26.3] | 24.81 [23-27.4] | .37 |
| RCM more than 125% of predicted | 11/59 (18.6%) | 38/62 (61.3%) | <.001 |
Q1, first quartile; Q3, third quartile; MCV, mean cell volume; WBC, white blood cell; ANC, absolute neutrophil count; BCM, below costal margin; and RCM, red cell mass.