Conditioning agents, doses, and dosing schedules for reduced-intensity BDDpfVIII transduced HSCTs
| Conditioning therapy . | Day relative to transplantation . | Total dose(s) . |
|---|---|---|
| TBI | 0 | 2 Gy |
| TBI and CY | 0/−3, −2 | 2 Gy, 200 mg/kg |
| CY | −3, −2 | 200 mg/kg |
| CY and FLU | −3, −2/−3, −2, −1 | 200 mg/kg, 90 mg/kg |
| BU | −3, −2 | 35 mg/kg* |
| BU and CY | −3, −2 | 35 mg/kg, 200 mg/kg |
| Conditioning therapy . | Day relative to transplantation . | Total dose(s) . |
|---|---|---|
| TBI | 0 | 2 Gy |
| TBI and CY | 0/−3, −2 | 2 Gy, 200 mg/kg |
| CY | −3, −2 | 200 mg/kg |
| CY and FLU | −3, −2/−3, −2, −1 | 200 mg/kg, 90 mg/kg |
| BU | −3, −2 | 35 mg/kg* |
| BU and CY | −3, −2 | 35 mg/kg, 200 mg/kg |
BU was administered at 35 mg/kg for toxicity and transplantation studies unless otherwise noted.