Table 2

Cluster 1 selected up-regulated genes

Gene symbolGene nameFold changeP
IGLC1; IGLC2 Immunoglobulin lambda constant and variable 8.63 .035 
IL26 Interleukin-26 8.44 .043 
IGHM Immunoglobulin heavy constant mu 7.16 .025 
POU2AF1 POU domain, class 2, associating factor 1 5.93 .016 
TNFRSF17 Tumor necrosis factor receptor superfamily, member 17 5.78 .040 
T3JAM TRAF3-interacting Jun N-terminal kinase (JNK)–activating modulator 4.73 < .001 
LEF1 Lymphoid enhancer-binding factor 1 4.66 .004 
SH2D1A SH2 domain protein 1A, Duncan disease 4.61 .006 
GNLY Granulysin 4.56 .041 
PTPN7 Protein tyrosine phosphatase, nonreceptor type 7 4.45 < .001 
FYB FYN binding protein (FYB-120/130) 4.44 < .001 
TNFSF14 Tumor necrosis factor (ligand) superfamily, member 14 4.16 < .001 
LCK Lymphocyte-specific protein tyrosine kinase 4.11 < .001 
RAC2 Ras-related C3 botulinum toxin substrate 2 4.10 < .001 
IL21R Interleukin-21 receptor 4.09 < .001 
TCRIM T-cell receptor interacting molecule 4.01 < .001 
ZAP70 ζ-chain (TCR)–associated protein kinase 70 kDa 3.89 < .001 
TNFSF4 Tumor necrosis factor (ligand) superfamily, member 4 3.86 .010 
CCR8 Chemokine (C-C motif) receptor 8 3.65 .031 
FUT7 Fucosyltransferase 7 (alpha (1,3) fucosyltransferase) 3.64 .007 
SELL Selectin L (lymphocyte adhesion molecule 1) 3.64 .012 
CD3G CD3G antigen, gamma polypeptide (TiT3 complex) 3.64 < .001 
CCL4 Chemokine (C-C motif) ligand 4 3.62 .042 
ITK IL-2–inducible T-cell kinase 3.61 < .001 
CXCL13 Chemokine (C-X-C motif) ligand 13 (B-cell chemoattractant) 3.60 .016 
IL2RA Interleukin-2 receptor α 3.49 .015 
TNIK TRAF2 and NCK interacting kinase 3.40 < .001 
IL2RB Interleukin-2 receptor β 3.29 < .001 
TNFRSF7 Tumor necrosis factor receptor superfamily, member 7 3.23 < .001 
TRBC1 T-cell receptor β constant 1 3.20 < .001 
LAT Linker for activation of T cells 3.16 < .001 
ST8SIA1 ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 1 3.01 .006 
IL2RG Interleukin-2 receptor γ (severe combined immunodeficiency) 3.01 < .001 
LILRB4 Leukocyte immunoglobulin-like receptor, subfamily B, member 4 2.95 .007 
CCR4 Chemokine (C-C motif) receptor 4 2.91 .003 
ITGAL Integrin αL 2.91 < .001 
CD3E CD3E antigen ϵ polypeptide (TiT3 complex) 2.89 < .001 
CD3Z CD3Z antigen ζ polypeptide (TiT3 complex) 2.88 < .001 
PRF1 Perforin 1 (pore-forming protein) 2.86 .009 
CCR5 Chemokine (C-C motif) receptor 5 2.84 .008 
LTB Lymphotoxin β (TNF superfamily, member 3) 2.82 .001 
CCR7 Chemokine (C-C motif) receptor 7 2.72 < .001 
BIRC3 Baculoviral IAP repeat–containing 3 2.71 .005 
MAP4K1 Mitogen-activated protein kinase 1 2.68 < .001 
IL27RA Interleukin-27 receptor α 2.67 < .001 
CD69 CD69 antigen (p60, early T-cell activation antigen) 2.67 .001 
IFNG Interferonγ 2.66 .009 
CXCR4 Chemokine (C-X-C motif) receptor 4 2.66 < .001 
CD3D CD3D antigen δ polypeptide (TiT3 complex) 2.58 < .001 
ST8SIA4 ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 4 2.57 .001 
MYB v-myb myeloblastosis viral oncogene homolog (avian) 2.55 .006 
ITGB7 Integrin β7 2.50 .002 
LPXN Leupaxin 2.40 < .001 
PTPRC Protein tyrosine phosphatase receptor type C 2.27 < .001 
TRA@ T-cell receptor α locus 2.25 < .001 
EVI2B Ecotropic viral integration site 2B 2.19 < .001 
TNF Tumor necrosis factor (TNF superfamily, member 2) 1.90 < .001 
TNFAIP8 Tumor necrosis factorα–induced protein 8 1.87 < .001 
WIF1 WNT inhibitory factor 1 4.93 .003 
IL1F7 Interleukin-1 family, member 7 (ζ) 4.17 < .001 
C1orf68 Chromosome 1 open reading frame 68 3.71 < .001 
PSORS1C2 Psoriasis susceptibility 1 candidate 2 3.06 < .001 
Gene symbolGene nameFold changeP
IGLC1; IGLC2 Immunoglobulin lambda constant and variable 8.63 .035 
IL26 Interleukin-26 8.44 .043 
IGHM Immunoglobulin heavy constant mu 7.16 .025 
POU2AF1 POU domain, class 2, associating factor 1 5.93 .016 
TNFRSF17 Tumor necrosis factor receptor superfamily, member 17 5.78 .040 
T3JAM TRAF3-interacting Jun N-terminal kinase (JNK)–activating modulator 4.73 < .001 
LEF1 Lymphoid enhancer-binding factor 1 4.66 .004 
SH2D1A SH2 domain protein 1A, Duncan disease 4.61 .006 
GNLY Granulysin 4.56 .041 
PTPN7 Protein tyrosine phosphatase, nonreceptor type 7 4.45 < .001 
FYB FYN binding protein (FYB-120/130) 4.44 < .001 
TNFSF14 Tumor necrosis factor (ligand) superfamily, member 14 4.16 < .001 
LCK Lymphocyte-specific protein tyrosine kinase 4.11 < .001 
RAC2 Ras-related C3 botulinum toxin substrate 2 4.10 < .001 
IL21R Interleukin-21 receptor 4.09 < .001 
TCRIM T-cell receptor interacting molecule 4.01 < .001 
ZAP70 ζ-chain (TCR)–associated protein kinase 70 kDa 3.89 < .001 
TNFSF4 Tumor necrosis factor (ligand) superfamily, member 4 3.86 .010 
CCR8 Chemokine (C-C motif) receptor 8 3.65 .031 
FUT7 Fucosyltransferase 7 (alpha (1,3) fucosyltransferase) 3.64 .007 
SELL Selectin L (lymphocyte adhesion molecule 1) 3.64 .012 
CD3G CD3G antigen, gamma polypeptide (TiT3 complex) 3.64 < .001 
CCL4 Chemokine (C-C motif) ligand 4 3.62 .042 
ITK IL-2–inducible T-cell kinase 3.61 < .001 
CXCL13 Chemokine (C-X-C motif) ligand 13 (B-cell chemoattractant) 3.60 .016 
IL2RA Interleukin-2 receptor α 3.49 .015 
TNIK TRAF2 and NCK interacting kinase 3.40 < .001 
IL2RB Interleukin-2 receptor β 3.29 < .001 
TNFRSF7 Tumor necrosis factor receptor superfamily, member 7 3.23 < .001 
TRBC1 T-cell receptor β constant 1 3.20 < .001 
LAT Linker for activation of T cells 3.16 < .001 
ST8SIA1 ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 1 3.01 .006 
IL2RG Interleukin-2 receptor γ (severe combined immunodeficiency) 3.01 < .001 
LILRB4 Leukocyte immunoglobulin-like receptor, subfamily B, member 4 2.95 .007 
CCR4 Chemokine (C-C motif) receptor 4 2.91 .003 
ITGAL Integrin αL 2.91 < .001 
CD3E CD3E antigen ϵ polypeptide (TiT3 complex) 2.89 < .001 
CD3Z CD3Z antigen ζ polypeptide (TiT3 complex) 2.88 < .001 
PRF1 Perforin 1 (pore-forming protein) 2.86 .009 
CCR5 Chemokine (C-C motif) receptor 5 2.84 .008 
LTB Lymphotoxin β (TNF superfamily, member 3) 2.82 .001 
CCR7 Chemokine (C-C motif) receptor 7 2.72 < .001 
BIRC3 Baculoviral IAP repeat–containing 3 2.71 .005 
MAP4K1 Mitogen-activated protein kinase 1 2.68 < .001 
IL27RA Interleukin-27 receptor α 2.67 < .001 
CD69 CD69 antigen (p60, early T-cell activation antigen) 2.67 .001 
IFNG Interferonγ 2.66 .009 
CXCR4 Chemokine (C-X-C motif) receptor 4 2.66 < .001 
CD3D CD3D antigen δ polypeptide (TiT3 complex) 2.58 < .001 
ST8SIA4 ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 4 2.57 .001 
MYB v-myb myeloblastosis viral oncogene homolog (avian) 2.55 .006 
ITGB7 Integrin β7 2.50 .002 
LPXN Leupaxin 2.40 < .001 
PTPRC Protein tyrosine phosphatase receptor type C 2.27 < .001 
TRA@ T-cell receptor α locus 2.25 < .001 
EVI2B Ecotropic viral integration site 2B 2.19 < .001 
TNF Tumor necrosis factor (TNF superfamily, member 2) 1.90 < .001 
TNFAIP8 Tumor necrosis factorα–induced protein 8 1.87 < .001 
WIF1 WNT inhibitory factor 1 4.93 .003 
IL1F7 Interleukin-1 family, member 7 (ζ) 4.17 < .001 
C1orf68 Chromosome 1 open reading frame 68 3.71 < .001 
PSORS1C2 Psoriasis susceptibility 1 candidate 2 3.06 < .001 
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